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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8UIP

Cryo-EM Structure of Human Ninjurin1 curved oligomer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001530molecular_functionlipopolysaccharide binding
A0002232biological_processleukocyte chemotaxis involved in inflammatory response
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006954biological_processinflammatory response
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0016020cellular_componentmembrane
A0019835biological_processcytolysis
A0031640biological_processkilling of cells of another organism
A0034113biological_processheterotypic cell-cell adhesion
A0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
A0042246biological_processtissue regeneration
A0042692biological_processmuscle cell differentiation
A0045766biological_processpositive regulation of angiogenesis
A0050729biological_processpositive regulation of inflammatory response
A0051260biological_processprotein homooligomerization
A0071474biological_processcellular hyperosmotic response
A0097060cellular_componentsynaptic membrane
A0097300biological_processprogrammed necrotic cell death
A0097707biological_processferroptosis
A0098631molecular_functioncell adhesion mediator activity
A0098632molecular_functioncell-cell adhesion mediator activity
A0140912molecular_functionmembrane destabilizing activity
A0141201biological_processpyroptotic cell death
B0001525biological_processangiogenesis
B0001530molecular_functionlipopolysaccharide binding
B0002232biological_processleukocyte chemotaxis involved in inflammatory response
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006954biological_processinflammatory response
B0007155biological_processcell adhesion
B0007399biological_processnervous system development
B0016020cellular_componentmembrane
B0019835biological_processcytolysis
B0031640biological_processkilling of cells of another organism
B0034113biological_processheterotypic cell-cell adhesion
B0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
B0042246biological_processtissue regeneration
B0042692biological_processmuscle cell differentiation
B0045766biological_processpositive regulation of angiogenesis
B0050729biological_processpositive regulation of inflammatory response
B0051260biological_processprotein homooligomerization
B0071474biological_processcellular hyperosmotic response
B0097060cellular_componentsynaptic membrane
B0097300biological_processprogrammed necrotic cell death
B0097707biological_processferroptosis
B0098631molecular_functioncell adhesion mediator activity
B0098632molecular_functioncell-cell adhesion mediator activity
B0140912molecular_functionmembrane destabilizing activity
B0141201biological_processpyroptotic cell death
C0001525biological_processangiogenesis
C0001530molecular_functionlipopolysaccharide binding
C0002232biological_processleukocyte chemotaxis involved in inflammatory response
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007155biological_processcell adhesion
C0007399biological_processnervous system development
C0016020cellular_componentmembrane
C0019835biological_processcytolysis
C0031640biological_processkilling of cells of another organism
C0034113biological_processheterotypic cell-cell adhesion
C0034145biological_processpositive regulation of toll-like receptor 4 signaling pathway
C0042246biological_processtissue regeneration
C0042692biological_processmuscle cell differentiation
C0045766biological_processpositive regulation of angiogenesis
C0050729biological_processpositive regulation of inflammatory response
C0051260biological_processprotein homooligomerization
C0071474biological_processcellular hyperosmotic response
C0097060cellular_componentsynaptic membrane
C0097300biological_processprogrammed necrotic cell death
C0097707biological_processferroptosis
C0098631molecular_functioncell adhesion mediator activity
C0098632molecular_functioncell-cell adhesion mediator activity
C0140912molecular_functionmembrane destabilizing activity
C0141201biological_processpyroptotic cell death
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Helix alpha3","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues27
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Helix alpha4","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues87
DetailsRegion: {"description":"Required to induce plasma membrane rupture","evidences":[{"source":"UniProtKB","id":"O70131","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues33
DetailsRegion: {"description":"Helix alpha1","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues48
DetailsRegion: {"description":"Helix alpha2","evidences":[{"source":"PubMed","id":"37198476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39667936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsSite: {"description":"Cleavage; by MMP9","evidences":[{"source":"UniProtKB","id":"O70131","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247035

PDB entries from 2026-01-07

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