Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8UGP

In-situ structure of typeA supercomplex in respiratory chain ( local refined map focused on CI iron-sulfur cluster regions )

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1A	0005743	cellular_component	mitochondrial inner membrane
1A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1A	0022904	biological_process	respiratory electron transport chain
1A	0045271	cellular_component	respiratory chain complex I
1A	1902600	biological_process	proton transmembrane transport
1B	0000166	molecular_function	nucleotide binding
1B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1B	0046872	molecular_function	metal ion binding
1B	0048038	molecular_function	quinone binding
1B	0051536	molecular_function	iron-sulfur cluster binding
1B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1B	1902600	biological_process	proton transmembrane transport
1C	0003954	molecular_function	NADH dehydrogenase activity
1C	0005739	cellular_component	mitochondrion
1C	0005743	cellular_component	mitochondrial inner membrane
1C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1C	0016020	cellular_component	membrane
1C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1C	0031966	cellular_component	mitochondrial membrane
1C	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1C	0045271	cellular_component	respiratory chain complex I
1C	0072593	biological_process	reactive oxygen species metabolic process
1C	1902600	biological_process	proton transmembrane transport
1D	0005743	cellular_component	mitochondrial inner membrane
1D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1D	0045271	cellular_component	respiratory chain complex I
1D	0048038	molecular_function	quinone binding
1D	0051287	molecular_function	NAD binding
1D	0051536	molecular_function	iron-sulfur cluster binding
1D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1D	1902600	biological_process	proton transmembrane transport
1G	0005739	cellular_component	mitochondrion
1G	0005743	cellular_component	mitochondrial inner membrane
1G	0005758	cellular_component	mitochondrial intermembrane space
1G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1G	0009055	molecular_function	electron transfer activity
1G	0016020	cellular_component	membrane
1G	0016491	molecular_function	oxidoreductase activity
1G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1G	0022904	biological_process	respiratory electron transport chain
1G	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1G	0042773	biological_process	ATP synthesis coupled electron transport
1G	0045271	cellular_component	respiratory chain complex I
1G	0045333	biological_process	cellular respiration
1G	0046872	molecular_function	metal ion binding
1G	0051536	molecular_function	iron-sulfur cluster binding
1G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
1G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1G	1902600	biological_process	proton transmembrane transport
1H	0003954	molecular_function	NADH dehydrogenase activity
1H	0005743	cellular_component	mitochondrial inner membrane
1H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1H	0009060	biological_process	aerobic respiration
1H	0016020	cellular_component	membrane
1H	0022904	biological_process	respiratory electron transport chain
1H	0031966	cellular_component	mitochondrial membrane
1H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1H	0045271	cellular_component	respiratory chain complex I
1H	1902600	biological_process	proton transmembrane transport
1I	0003954	molecular_function	NADH dehydrogenase activity
1I	0005739	cellular_component	mitochondrion
1I	0005743	cellular_component	mitochondrial inner membrane
1I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1I	0016020	cellular_component	membrane
1I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
1I	0022904	biological_process	respiratory electron transport chain
1I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1I	0045271	cellular_component	respiratory chain complex I
1I	0046872	molecular_function	metal ion binding
1I	0051536	molecular_function	iron-sulfur cluster binding
1I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1I	1902600	biological_process	proton transmembrane transport
1P	0000166	molecular_function	nucleotide binding
1P	0005759	cellular_component	mitochondrial matrix
1P	0022904	biological_process	respiratory electron transport chain
1q	0005743	cellular_component	mitochondrial inner membrane
1q	0016020	cellular_component	membrane
1q	0022904	biological_process	respiratory electron transport chain
1q	0045271	cellular_component	respiratory chain complex I
1Q	0005739	cellular_component	mitochondrion
1Q	0005743	cellular_component	mitochondrial inner membrane
1Q	0007420	biological_process	brain development
1Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1Q	0016020	cellular_component	membrane
1Q	0022900	biological_process	electron transport chain
1Q	0022904	biological_process	respiratory electron transport chain
1Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
1Q	0045271	cellular_component	respiratory chain complex I
1Q	0051591	biological_process	response to cAMP
1Q	0072593	biological_process	reactive oxygen species metabolic process
1Q	1902600	biological_process	proton transmembrane transport
1R	0005739	cellular_component	mitochondrion
1R	0005743	cellular_component	mitochondrial inner membrane
1R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
1R	0022904	biological_process	respiratory electron transport chain
1R	0045271	cellular_component	respiratory chain complex I
1R	0046872	molecular_function	metal ion binding
1W	0005743	cellular_component	mitochondrial inner membrane
1W	0022904	biological_process	respiratory electron transport chain
1W	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
1I	CYS77-PRO88
1I	CYS116-PRO127

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
1D	LEU83-LYS94

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
1C	GLU131-LEU152

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
1G	PRO38-CYS55

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
1G	CYS105-GLN117

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
1G	ARG152-PHE162

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLVtKE

Chain	Residue	Details
1H	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
1H	PRO197-GLY210

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
1B	GLY254-PRO270

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)