Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8UGL

High resolution in-situ structure of complex IV in respiratory supercomplex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
4A	0004129	molecular_function	cytochrome-c oxidase activity
4A	0005739	cellular_component	mitochondrion
4A	0005743	cellular_component	mitochondrial inner membrane
4A	0006119	biological_process	oxidative phosphorylation
4A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4A	0015990	biological_process	electron transport coupled proton transport
4A	0045277	cellular_component	respiratory chain complex IV
4A	0046872	molecular_function	metal ion binding
4B	0004129	molecular_function	cytochrome-c oxidase activity
4B	0005739	cellular_component	mitochondrion
4B	0005743	cellular_component	mitochondrial inner membrane
4B	0031966	cellular_component	mitochondrial membrane
4B	0042773	biological_process	ATP synthesis coupled electron transport
4B	0045277	cellular_component	respiratory chain complex IV
4B	0045907	biological_process	positive regulation of vasoconstriction
4B	0046872	molecular_function	metal ion binding
4B	1902600	biological_process	proton transmembrane transport
4C	0004129	molecular_function	cytochrome-c oxidase activity
4C	0005739	cellular_component	mitochondrion
4C	0005743	cellular_component	mitochondrial inner membrane
4C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4C	0008535	biological_process	respiratory chain complex IV assembly
4C	0045277	cellular_component	respiratory chain complex IV
4C	1902600	biological_process	proton transmembrane transport
4D	0005739	cellular_component	mitochondrion
4D	0005743	cellular_component	mitochondrial inner membrane
4D	0006119	biological_process	oxidative phosphorylation
4E	0005739	cellular_component	mitochondrion
4E	0005743	cellular_component	mitochondrial inner membrane
4E	0006119	biological_process	oxidative phosphorylation
4E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4E	0031966	cellular_component	mitochondrial membrane
4E	0045277	cellular_component	respiratory chain complex IV
4E	0046872	molecular_function	metal ion binding
4F	0005739	cellular_component	mitochondrion
4F	0005743	cellular_component	mitochondrial inner membrane
4F	0006119	biological_process	oxidative phosphorylation
4F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4F	0046872	molecular_function	metal ion binding
4G	0005739	cellular_component	mitochondrion
4G	0005743	cellular_component	mitochondrial inner membrane
4G	0006119	biological_process	oxidative phosphorylation
4G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4G	0016491	molecular_function	oxidoreductase activity
4G	0030234	molecular_function	enzyme regulator activity
4G	0045277	cellular_component	respiratory chain complex IV
4H	0005739	cellular_component	mitochondrion
4H	0005743	cellular_component	mitochondrial inner membrane
4I	0005739	cellular_component	mitochondrion
4I	0005743	cellular_component	mitochondrial inner membrane
4I	0006119	biological_process	oxidative phosphorylation
4I	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4I	0031966	cellular_component	mitochondrial membrane
4J	0002082	biological_process	regulation of oxidative phosphorylation
4J	0005739	cellular_component	mitochondrion
4J	0005743	cellular_component	mitochondrial inner membrane
4J	0006119	biological_process	oxidative phosphorylation
4J	0016491	molecular_function	oxidoreductase activity
4J	0097250	biological_process	mitochondrial respirasome assembly
4J	0098803	cellular_component	respiratory chain complex
4K	0005739	cellular_component	mitochondrion
4K	0005743	cellular_component	mitochondrial inner membrane
4K	0006119	biological_process	oxidative phosphorylation
4K	0007417	biological_process	central nervous system development
4K	0031966	cellular_component	mitochondrial membrane
4K	0045277	cellular_component	respiratory chain complex IV
4L	0005739	cellular_component	mitochondrion
4L	0005743	cellular_component	mitochondrial inner membrane
4L	0006119	biological_process	oxidative phosphorylation
4L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4L	0045277	cellular_component	respiratory chain complex IV
4M	0005739	cellular_component	mitochondrion
4M	0005743	cellular_component	mitochondrial inner membrane
4M	0006119	biological_process	oxidative phosphorylation
4M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
4N	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
4A	TRP236-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmstrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
4B	VAL159-MET207

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwvhkgetqrCpsCGthYKL

Chain	Residue	Details
4F	VAL69-LEU91

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpYsWGDGnHTlFhN

Chain	Residue	Details
4G	ILE55-ASN72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250\|UniProtKB:P00430

Chain	Residue	Details
4L	SER1-ASN17
4F	CYS62
4F	CYS82
4F	CYS85
4A	HIS328-SER335
4A	SER401-ASN406
4A	LYS479-LYS514

site_id	SWS_FT_FI2
Number of Residues	26
Details	TRANSMEM: Helical => ECO:0000250\|UniProtKB:P00430

Chain	Residue	Details
4L	LYS18-LEU44
4F	LYS55
4F	LYS90

site_id	SWS_FT_FI3
Number of Residues	2
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000250\|UniProtKB:P00430

Chain	Residue	Details
4L	LEU45-LYS47
4C	LEU106-GLU128
4C	ALA184-ASP190
4C	TYR257-SER261
4A	LEU358-THR370
4A	SER434-ALA446

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P17665

Chain	Residue	Details
4L	LYS9

site_id	SWS_FT_FI5
Number of Residues	32
Details	TRANSMEM: Helical; Name=III => ECO:0000250\|UniProtKB:P00415

Chain	Residue	Details
4C	SER73-SER105

site_id	SWS_FT_FI6
Number of Residues	23
Details	TRANSMEM: Helical; Name=IV => ECO:0000250\|UniProtKB:P00415

Chain	Residue	Details
4C	VAL129-MET152

site_id	SWS_FT_FI7
Number of Residues	27
Details	TRANSMEM: Helical; Name=V => ECO:0000250\|UniProtKB:P00415

Chain	Residue	Details
4C	ARG156-GLU183

site_id	SWS_FT_FI8
Number of Residues	32
Details	TRANSMEM: Helical; Name=VI => ECO:0000250\|UniProtKB:P00415

Chain	Residue	Details
4C	GLY191-LEU223

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=VII => ECO:0000250\|UniProtKB:P00415

Chain	Residue	Details
4C	PHE233-ILE256

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=VIII => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	VAL299-LEU327

site_id	SWS_FT_FI11
Number of Residues	21
Details	TRANSMEM: Helical; Name=IX => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	PRO336-VAL357

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=X => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	TYR371-PHE400

site_id	SWS_FT_FI13
Number of Residues	26
Details	TRANSMEM: Helical; Name=XI => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	GLN407-LEU433

site_id	SWS_FT_FI14
Number of Residues	31
Details	TRANSMEM: Helical; Name=XII => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	TYR447-SER478

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	GLU40
4A	GLY45
4A	HIS240
4A	TYR244
4A	HIS290
4A	HIS291
4A	HIS368
4A	ASP369
4A	SER441

site_id	SWS_FT_FI16
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	HIS61
4A	HIS376
4A	HIS378

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
4A	HIS240
4A	TYR244

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)