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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8UGL

High resolution in-situ structure of complex IV in respiratory supercomplex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
4A0004129molecular_functioncytochrome-c oxidase activity
4A0005739cellular_componentmitochondrion
4A0005743cellular_componentmitochondrial inner membrane
4A0006119biological_processoxidative phosphorylation
4A0009060biological_processaerobic respiration
4A0016020cellular_componentmembrane
4A0020037molecular_functionheme binding
4A0022904biological_processrespiratory electron transport chain
4A0031966cellular_componentmitochondrial membrane
4A0045277cellular_componentrespiratory chain complex IV
4A0046872molecular_functionmetal ion binding
4A1902600biological_processproton transmembrane transport
4B0004129molecular_functioncytochrome-c oxidase activity
4B0005507molecular_functioncopper ion binding
4B0005739cellular_componentmitochondrion
4B0005743cellular_componentmitochondrial inner membrane
4B0016020cellular_componentmembrane
4B0016491molecular_functionoxidoreductase activity
4B0022900biological_processelectron transport chain
4B0022904biological_processrespiratory electron transport chain
4B0031966cellular_componentmitochondrial membrane
4B0042773biological_processATP synthesis coupled electron transport
4B0045277cellular_componentrespiratory chain complex IV
4B0045907biological_processpositive regulation of vasoconstriction
4B0046872molecular_functionmetal ion binding
4B1902600biological_processproton transmembrane transport
4C0004129molecular_functioncytochrome-c oxidase activity
4C0005739cellular_componentmitochondrion
4C0005743cellular_componentmitochondrial inner membrane
4C0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4C0008535biological_processrespiratory chain complex IV assembly
4C0009055molecular_functionelectron transfer activity
4C0016020cellular_componentmembrane
4C0019646biological_processaerobic electron transport chain
4C0022904biological_processrespiratory electron transport chain
4C0031966cellular_componentmitochondrial membrane
4C0045277cellular_componentrespiratory chain complex IV
4C1902600biological_processproton transmembrane transport
4D0005743cellular_componentmitochondrial inner membrane
4D0006119biological_processoxidative phosphorylation
4D0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4D0045277cellular_componentrespiratory chain complex IV
4E0005739cellular_componentmitochondrion
4E0005743cellular_componentmitochondrial inner membrane
4E0006119biological_processoxidative phosphorylation
4E0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4E0031966cellular_componentmitochondrial membrane
4E0045277cellular_componentrespiratory chain complex IV
4E0046872molecular_functionmetal ion binding
4F0005739cellular_componentmitochondrion
4F0005740cellular_componentmitochondrial envelope
4F0005743cellular_componentmitochondrial inner membrane
4F0006119biological_processoxidative phosphorylation
4F0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4F0045277cellular_componentrespiratory chain complex IV
4F0046872molecular_functionmetal ion binding
4G0005743cellular_componentmitochondrial inner membrane
4G0006119biological_processoxidative phosphorylation
4G0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4G0016491molecular_functionoxidoreductase activity
4G0030234molecular_functionenzyme regulator activity
4G0045277cellular_componentrespiratory chain complex IV
4H0005739cellular_componentmitochondrion
4H0005743cellular_componentmitochondrial inner membrane
4H0016020cellular_componentmembrane
4H0045277cellular_componentrespiratory chain complex IV
4I0005739cellular_componentmitochondrion
4I0005743cellular_componentmitochondrial inner membrane
4I0006119biological_processoxidative phosphorylation
4I0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4I0016020cellular_componentmembrane
4I0031966cellular_componentmitochondrial membrane
4I0045277cellular_componentrespiratory chain complex IV
4J0004129molecular_functioncytochrome-c oxidase activity
4J0005739cellular_componentmitochondrion
4J0005743cellular_componentmitochondrial inner membrane
4J0006119biological_processoxidative phosphorylation
4J0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4J0016491molecular_functionoxidoreductase activity
4J0030674molecular_functionprotein-macromolecule adaptor activity
4J0031966cellular_componentmitochondrial membrane
4J0045277cellular_componentrespiratory chain complex IV
4J0097250biological_processmitochondrial respirasome assembly
4J0098803cellular_componentrespiratory chain complex
4J1902600biological_processproton transmembrane transport
4K0005739cellular_componentmitochondrion
4K0005743cellular_componentmitochondrial inner membrane
4K0006119biological_processoxidative phosphorylation
4K0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4K0007417biological_processcentral nervous system development
4K0016020cellular_componentmembrane
4K0031966cellular_componentmitochondrial membrane
4K0045277cellular_componentrespiratory chain complex IV
4L0005743cellular_componentmitochondrial inner membrane
4L0006119biological_processoxidative phosphorylation
4L0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4L0031966cellular_componentmitochondrial membrane
4L0045277cellular_componentrespiratory chain complex IV
4M0005739cellular_componentmitochondrion
4M0005743cellular_componentmitochondrial inner membrane
4M0006119biological_processoxidative phosphorylation
4M0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
4M0045277cellular_componentrespiratory chain complex IV
4N0005743cellular_componentmitochondrial inner membrane
4N0022904biological_processrespiratory electron transport chain
Functional Information from PROSITE/UniProt
site_idPS00077
Number of Residues56
DetailsCOX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH
ChainResidueDetails
4ATRP236-HIS291
site_idPS00078
Number of Residues49
DetailsCOX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmstrpglyygq......CseiCgsnHsfM
ChainResidueDetails
4BVAL159-MET207
site_idPS00848
Number of Residues23
DetailsCOX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwvhkgetqrCpsCGthYKL
ChainResidueDetails
4FVAL69-LEU91
site_idPS01329
Number of Residues18
DetailsCOX6A Cytochrome c oxidase subunit VIa signature. IRtKpYsWGDGnHTlFhN
ChainResidueDetails
4GILE55-ASN72
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=I","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues80
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues35
DetailsTransmembrane: {"description":"Helical; Name=II","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues72
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=III","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=V","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues33
DetailsTransmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=VIII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=IX","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=X","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=XI","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues31
DetailsTransmembrane: {"description":"Helical; Name=XII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsBinding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsCross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=I","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues37
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=II","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues15
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues32
DetailsTransmembrane: {"description":"Helical; Name=III","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=V","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues32
DetailsTransmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00692","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19536","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues24
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P07470","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues28
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P07470","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues26
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P00430","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues2
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P00430","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17665","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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