8UCP
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Serotonin
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 55 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishivstyskkpvfgaigmvyamgsigflgllvws..HH |
| Chain | Residue | Details |
| a | TRP239-HIS293 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfcvpalgvkvdaspgrlnqtsaliqregvyygq......CselCgvmHsaM |
| Chain | Residue | Details |
| b | VAL182-MET230 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-LYS20 | |
| A | LEU151-PRO159 | |
| A | TYR211-ASN219 | |
| A | PRO272-ASP291 | |
| A | HIS353-ARG357 | |
| A | ASP411-HIS414 | |
| A | PHE463-ASP514 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 247 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU21-VAL41 | |
| A | GLY390-VAL410 | |
| A | VAL415-ILE435 | |
| A | GLY441-LEU462 | |
| A | GLN130-GLY150 | |
| A | ILE160-SER180 | |
| A | SER190-VAL210 | |
| A | VAL220-LEU242 | |
| A | THR249-GLN271 | |
| A | PRO292-LEU311 | |
| A | GLN329-ALA352 | |
| A | TRP358-ALA378 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | TOPO_DOM: Lumenal, vesicle => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO42-VAL129 | |
| A | SER181-ARG189 | |
| A | TYR243-LYS248 | |
| A | GLU312-TRP328 | |
| A | LYS379-PHE389 | |
| A | GLY436-GLY440 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01827 |
| Chain | Residue | Details |
| A | SER511 | |
| A | SER513 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN84 | |
| A | ASN91 |
