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8UCN

Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Histamine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001975biological_processresponse to amphetamine
A0002552biological_processserotonin secretion by mast cell
A0002553biological_processhistamine secretion by mast cell
A0005335molecular_functionserotonin:sodium:chloride symporter activity
A0005515molecular_functionprotein binding
A0005813cellular_componentcentrosome
A0005886cellular_componentplasma membrane
A0006836biological_processneurotransmitter transport
A0007268biological_processchemical synaptic transmission
A0007626biological_processlocomotory behavior
A0008021cellular_componentsynaptic vesicle
A0008504molecular_functionmonoamine transmembrane transporter activity
A0009636biological_processresponse to toxic substance
A0009791biological_processpost-embryonic development
A0015311molecular_functionmonoamine:proton antiporter activity
A0015842biological_processaminergic neurotransmitter loading into synaptic vesicle
A0015844biological_processmonoamine transport
A0015872biological_processdopamine transport
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0042137biological_processsequestering of neurotransmitter
A0042995cellular_componentcell projection
A0043195cellular_componentterminal bouton
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0051610biological_processserotonin uptake
A0051615biological_processhistamine uptake
A0070083cellular_componentclathrin-sculpted monoamine transport vesicle membrane
A0098691cellular_componentdopaminergic synapse
A0098700biological_processneurotransmitter loading into synaptic vesicle
A0099123biological_processsomato-dendritic dopamine secretion
A1902600biological_processproton transmembrane transport
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
a0004129molecular_functioncytochrome-c oxidase activity
a0005739cellular_componentmitochondrion
a0005743cellular_componentmitochondrial inner membrane
a0006119biological_processoxidative phosphorylation
a0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
a0015990biological_processelectron transport coupled proton transport
a0046872molecular_functionmetal ion binding
c0004129molecular_functioncytochrome-c oxidase activity
c0005739cellular_componentmitochondrion
c0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
c0016020cellular_componentmembrane
c1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00077
Number of Residues55
DetailsCOX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishivstyskkpvfgaigmvyamgsigflgllvws..HH
ChainResidueDetails
aTRP239-HIS293

site_idPS00078
Number of Residues49
DetailsCOX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfcvpalgvkvdaspgrlnqtsaliqregvyygq......CselCgvmHsaM
ChainResidueDetails
bVAL182-MET230

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-LYS20
ALEU151-PRO159
ATYR211-ASN219
APRO272-ASP291
AHIS353-ARG357
AASP411-HIS414
APHE463-ASP514

site_idSWS_FT_FI2
Number of Residues247
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU21-VAL41
AGLY390-VAL410
AVAL415-ILE435
AGLY441-LEU462
AGLN130-GLY150
AILE160-SER180
ASER190-VAL210
AVAL220-LEU242
ATHR249-GLN271
APRO292-LEU311
AGLN329-ALA352
ATRP358-ALA378

site_idSWS_FT_FI3
Number of Residues130
DetailsTOPO_DOM: Lumenal, vesicle => ECO:0000255
ChainResidueDetails
APRO42-VAL129
ASER181-ARG189
ATYR243-LYS248
AGLU312-TRP328
ALYS379-PHE389
AGLY436-GLY440

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01827
ChainResidueDetails
ASER511
ASER513

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN84
AASN91

227344

PDB entries from 2024-11-13

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