8UBY
Choline-bound FLVCR1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001568 | biological_process | blood vessel development |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0015220 | molecular_function | choline transmembrane transporter activity |
| A | 0015232 | molecular_function | heme transmembrane transporter activity |
| A | 0015871 | biological_process | choline transport |
| A | 0015886 | biological_process | heme transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030218 | biological_process | erythrocyte differentiation |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034228 | molecular_function | ethanolamine transmembrane transporter activity |
| A | 0034229 | biological_process | ethanolamine transport |
| A | 0035108 | biological_process | limb morphogenesis |
| A | 0035264 | biological_process | multicellular organism growth |
| A | 0042733 | biological_process | embryonic digit morphogenesis |
| A | 0043249 | biological_process | erythrocyte maturation |
| A | 0046620 | biological_process | regulation of organ growth |
| A | 0048536 | biological_process | spleen development |
| A | 0048704 | biological_process | embryonic skeletal system morphogenesis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060323 | biological_process | head morphogenesis |
| A | 0097037 | biological_process | heme export |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 48 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38693265","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8R8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UBX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
