8UBL

Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome (3D Flex map)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0016020	cellular_component	membrane
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0008285	biological_process	negative regulation of cell population proliferation
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome
D	0000786	cellular_component	nucleosome
D	0001530	molecular_function	lipopolysaccharide binding
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005886	cellular_component	plasma membrane
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0045296	molecular_function	cadherin binding
E	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0008285	biological_process	negative regulation of cell population proliferation
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0070062	cellular_component	extracellular exosome
H	0000786	cellular_component	nucleosome
H	0001530	molecular_function	lipopolysaccharide binding
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005886	cellular_component	plasma membrane
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
O	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
O	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
O	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
O	0001764	biological_process	neuron migration
O	0003358	biological_process	noradrenergic neuron development
O	0003359	biological_process	noradrenergic neuron fate commitment
O	0003676	molecular_function	nucleic acid binding
O	0003682	molecular_function	chromatin binding
O	0003690	molecular_function	double-stranded DNA binding
O	0003700	molecular_function	DNA-binding transcription factor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0007219	biological_process	Notch signaling pathway
O	0007346	biological_process	regulation of mitotic cell cycle
O	0007389	biological_process	pattern specification process
O	0007399	biological_process	nervous system development
O	0007400	biological_process	neuroblast fate determination
O	0007405	biological_process	neuroblast proliferation
O	0007423	biological_process	sensory organ development
O	0007507	biological_process	heart development
O	0008593	biological_process	regulation of Notch signaling pathway
O	0010001	biological_process	glial cell differentiation
O	0010468	biological_process	regulation of gene expression
O	0014003	biological_process	oligodendrocyte development
O	0021527	biological_process	spinal cord association neuron differentiation
O	0021529	biological_process	spinal cord oligodendrocyte cell differentiation
O	0021530	biological_process	spinal cord oligodendrocyte cell fate specification
O	0021750	biological_process	vestibular nucleus development
O	0021779	biological_process	oligodendrocyte cell fate commitment
O	0021879	biological_process	forebrain neuron differentiation
O	0021892	biological_process	cerebral cortex GABAergic interneuron differentiation
O	0021902	biological_process	commitment of neuronal cell to specific neuron type in forebrain
O	0021954	biological_process	central nervous system neuron development
O	0021987	biological_process	cerebral cortex development
O	0022008	biological_process	neurogenesis
O	0030154	biological_process	cell differentiation
O	0030182	biological_process	neuron differentiation
O	0030856	biological_process	regulation of epithelial cell differentiation
O	0032526	biological_process	response to retinoic acid
O	0042127	biological_process	regulation of cell population proliferation
O	0042802	molecular_function	identical protein binding
O	0043025	cellular_component	neuronal cell body
O	0043066	biological_process	negative regulation of apoptotic process
O	0043425	molecular_function	bHLH transcription factor binding
O	0043525	biological_process	positive regulation of neuron apoptotic process
O	0043565	molecular_function	sequence-specific DNA binding
O	0045595	biological_process	regulation of cell differentiation
O	0045665	biological_process	negative regulation of neuron differentiation
O	0045666	biological_process	positive regulation of neuron differentiation
O	0045747	biological_process	positive regulation of Notch signaling pathway
O	0045787	biological_process	positive regulation of cell cycle
O	0045892	biological_process	negative regulation of DNA-templated transcription
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0048469	biological_process	cell maturation
O	0048484	biological_process	enteric nervous system development
O	0048485	biological_process	sympathetic nervous system development
O	0048486	biological_process	parasympathetic nervous system development
O	0048663	biological_process	neuron fate commitment
O	0048665	biological_process	neuron fate specification
O	0048666	biological_process	neuron development
O	0048699	biological_process	generation of neurons
O	0048709	biological_process	oligodendrocyte differentiation
O	0050767	biological_process	regulation of neurogenesis
O	0050769	biological_process	positive regulation of neurogenesis
O	0050883	biological_process	musculoskeletal movement, spinal reflex action
O	0051593	biological_process	response to folic acid
O	0060163	biological_process	subpallium neuron fate commitment
O	0060165	biological_process	regulation of timing of subpallium neuron differentiation
O	0060166	biological_process	olfactory pit development
O	0060579	biological_process	ventral spinal cord interneuron fate commitment
O	0061100	biological_process	lung neuroendocrine cell differentiation
O	0061102	biological_process	stomach neuroendocrine cell differentiation
O	0061103	biological_process	carotid body glomus cell differentiation
O	0061104	biological_process	adrenal chromaffin cell differentiation
O	0061549	biological_process	sympathetic ganglion development
O	0070849	biological_process	response to epidermal growth factor
O	0070888	molecular_function	E-box binding
O	0071259	biological_process	cellular response to magnetism
O	0090575	cellular_component	RNA polymerase II transcription regulator complex
O	1990837	molecular_function	sequence-specific double-stranded DNA binding
O	2000179	biological_process	positive regulation of neural precursor cell proliferation
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0000785	cellular_component	chromatin
P	0000786	cellular_component	nucleosome
P	0000791	cellular_component	euchromatin
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
P	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
P	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
P	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
P	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
P	0001779	biological_process	natural killer cell differentiation
P	0002326	biological_process	B cell lineage commitment
P	0003677	molecular_function	DNA binding
P	0003682	molecular_function	chromatin binding
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005667	cellular_component	transcription regulator complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006338	biological_process	chromatin remodeling
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0007369	biological_process	gastrulation
P	0009410	biological_process	response to xenobiotic stimulus
P	0010628	biological_process	positive regulation of gene expression
P	0030098	biological_process	lymphocyte differentiation
P	0030165	molecular_function	PDZ domain binding
P	0030890	biological_process	positive regulation of B cell proliferation
P	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
P	0032496	biological_process	response to lipopolysaccharide
P	0032991	cellular_component	protein-containing complex
P	0033077	biological_process	T cell differentiation in thymus
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0043425	molecular_function	bHLH transcription factor binding
P	0043565	molecular_function	sequence-specific DNA binding
P	0045666	biological_process	positive regulation of neuron differentiation
P	0045787	biological_process	positive regulation of cell cycle
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0046982	molecular_function	protein heterodimerization activity
P	0048468	biological_process	cell development
P	0048541	biological_process	Peyer's patch development
P	0050821	biological_process	protein stabilization
P	0051091	biological_process	obsolete positive regulation of DNA-binding transcription factor activity
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0070644	molecular_function	vitamin D response element binding
P	0070888	molecular_function	E-box binding
P	0090575	cellular_component	RNA polymerase II transcription regulator complex
P	0140297	molecular_function	DNA-binding transcription factor binding
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Q	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Q	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
Q	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
Q	0001764	biological_process	neuron migration
Q	0003358	biological_process	noradrenergic neuron development
Q	0003359	biological_process	noradrenergic neuron fate commitment
Q	0003676	molecular_function	nucleic acid binding
Q	0003682	molecular_function	chromatin binding
Q	0003690	molecular_function	double-stranded DNA binding
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0007219	biological_process	Notch signaling pathway
Q	0007346	biological_process	regulation of mitotic cell cycle
Q	0007389	biological_process	pattern specification process
Q	0007399	biological_process	nervous system development
Q	0007400	biological_process	neuroblast fate determination
Q	0007405	biological_process	neuroblast proliferation
Q	0007423	biological_process	sensory organ development
Q	0007507	biological_process	heart development
Q	0008593	biological_process	regulation of Notch signaling pathway
Q	0010001	biological_process	glial cell differentiation
Q	0010468	biological_process	regulation of gene expression
Q	0014003	biological_process	oligodendrocyte development
Q	0021527	biological_process	spinal cord association neuron differentiation
Q	0021529	biological_process	spinal cord oligodendrocyte cell differentiation
Q	0021530	biological_process	spinal cord oligodendrocyte cell fate specification
Q	0021750	biological_process	vestibular nucleus development
Q	0021779	biological_process	oligodendrocyte cell fate commitment
Q	0021879	biological_process	forebrain neuron differentiation
Q	0021892	biological_process	cerebral cortex GABAergic interneuron differentiation
Q	0021902	biological_process	commitment of neuronal cell to specific neuron type in forebrain
Q	0021954	biological_process	central nervous system neuron development
Q	0021987	biological_process	cerebral cortex development
Q	0022008	biological_process	neurogenesis
Q	0030154	biological_process	cell differentiation
Q	0030182	biological_process	neuron differentiation
Q	0030856	biological_process	regulation of epithelial cell differentiation
Q	0032526	biological_process	response to retinoic acid
Q	0042127	biological_process	regulation of cell population proliferation
Q	0042802	molecular_function	identical protein binding
Q	0043025	cellular_component	neuronal cell body
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043425	molecular_function	bHLH transcription factor binding
Q	0043525	biological_process	positive regulation of neuron apoptotic process
Q	0043565	molecular_function	sequence-specific DNA binding
Q	0045595	biological_process	regulation of cell differentiation
Q	0045665	biological_process	negative regulation of neuron differentiation
Q	0045666	biological_process	positive regulation of neuron differentiation
Q	0045747	biological_process	positive regulation of Notch signaling pathway
Q	0045787	biological_process	positive regulation of cell cycle
Q	0045892	biological_process	negative regulation of DNA-templated transcription
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0048469	biological_process	cell maturation
Q	0048484	biological_process	enteric nervous system development
Q	0048485	biological_process	sympathetic nervous system development
Q	0048486	biological_process	parasympathetic nervous system development
Q	0048663	biological_process	neuron fate commitment
Q	0048665	biological_process	neuron fate specification
Q	0048666	biological_process	neuron development
Q	0048699	biological_process	generation of neurons
Q	0048709	biological_process	oligodendrocyte differentiation
Q	0050767	biological_process	regulation of neurogenesis
Q	0050769	biological_process	positive regulation of neurogenesis
Q	0050883	biological_process	musculoskeletal movement, spinal reflex action
Q	0051593	biological_process	response to folic acid
Q	0060163	biological_process	subpallium neuron fate commitment
Q	0060165	biological_process	regulation of timing of subpallium neuron differentiation
Q	0060166	biological_process	olfactory pit development
Q	0060579	biological_process	ventral spinal cord interneuron fate commitment
Q	0061100	biological_process	lung neuroendocrine cell differentiation
Q	0061102	biological_process	stomach neuroendocrine cell differentiation
Q	0061103	biological_process	carotid body glomus cell differentiation
Q	0061104	biological_process	adrenal chromaffin cell differentiation
Q	0061549	biological_process	sympathetic ganglion development
Q	0070849	biological_process	response to epidermal growth factor
Q	0070888	molecular_function	E-box binding
Q	0071259	biological_process	cellular response to magnetism
Q	0090575	cellular_component	RNA polymerase II transcription regulator complex
Q	1990837	molecular_function	sequence-specific double-stranded DNA binding
Q	2000179	biological_process	positive regulation of neural precursor cell proliferation
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000785	cellular_component	chromatin
R	0000786	cellular_component	nucleosome
R	0000791	cellular_component	euchromatin
R	0000976	molecular_function	transcription cis-regulatory region binding
R	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
R	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
R	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
R	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
R	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
R	0001779	biological_process	natural killer cell differentiation
R	0002326	biological_process	B cell lineage commitment
R	0003677	molecular_function	DNA binding
R	0003682	molecular_function	chromatin binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005667	cellular_component	transcription regulator complex
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0007369	biological_process	gastrulation
R	0009410	biological_process	response to xenobiotic stimulus
R	0010628	biological_process	positive regulation of gene expression
R	0030098	biological_process	lymphocyte differentiation
R	0030165	molecular_function	PDZ domain binding
R	0030890	biological_process	positive regulation of B cell proliferation
R	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
R	0032496	biological_process	response to lipopolysaccharide
R	0032991	cellular_component	protein-containing complex
R	0033077	biological_process	T cell differentiation in thymus
R	0033152	biological_process	immunoglobulin V(D)J recombination
R	0042802	molecular_function	identical protein binding
R	0042803	molecular_function	protein homodimerization activity
R	0043425	molecular_function	bHLH transcription factor binding
R	0043565	molecular_function	sequence-specific DNA binding
R	0045666	biological_process	positive regulation of neuron differentiation
R	0045787	biological_process	positive regulation of cell cycle
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046982	molecular_function	protein heterodimerization activity
R	0048468	biological_process	cell development
R	0048541	biological_process	Peyer's patch development
R	0050821	biological_process	protein stabilization
R	0051091	biological_process	obsolete positive regulation of DNA-binding transcription factor activity
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0070644	molecular_function	vitamin D response element binding
R	0070888	molecular_function	E-box binding
R	0090575	cellular_component	RNA polymerase II transcription regulator complex
R	0140297	molecular_function	DNA-binding transcription factor binding
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"15983376","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"12086618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17967882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338793","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32209475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"PubMed","id":"34961760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"N6-benzoyllysine; alternate","evidences":[{"source":"PubMed","id":"30154464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-isonicotinyllysine","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"N6-isonicotinyllysine; alternate","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	210
Details	Domain: {"description":"bHLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---