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8U87

Structural Basis of Human NOX5 Activation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001819biological_processpositive regulation of cytokine production
A0001935biological_processendothelial cell proliferation
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0006952biological_processdefense response
A0015252molecular_functionproton channel activity
A0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0034220biological_processmonoatomic ion transmembrane transport
A0042554biological_processsuperoxide anion generation
A0043012biological_processregulation of fusion of sperm to egg plasma membrane
A0043020cellular_componentNADPH oxidase complex
A0046872molecular_functionmetal ion binding
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
A0061640biological_processcytoskeleton-dependent cytokinesis
A0106292molecular_functionsuperoxide-generating NADPH oxidase activity
A1902600biological_processproton transmembrane transport
C0001525biological_processangiogenesis
C0001819biological_processpositive regulation of cytokine production
C0001935biological_processendothelial cell proliferation
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006952biological_processdefense response
C0015252molecular_functionproton channel activity
C0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
C0016491molecular_functionoxidoreductase activity
C0020037molecular_functionheme binding
C0034220biological_processmonoatomic ion transmembrane transport
C0042554biological_processsuperoxide anion generation
C0043012biological_processregulation of fusion of sperm to egg plasma membrane
C0043020cellular_componentNADPH oxidase complex
C0046872molecular_functionmetal ion binding
C0050660molecular_functionflavin adenine dinucleotide binding
C0050661molecular_functionNADP binding
C0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
C0061640biological_processcytoskeleton-dependent cytokinesis
C0106292molecular_functionsuperoxide-generating NADPH oxidase activity
C1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DSDRSGTITlqEL
ChainResidueDetails
AASP52-LEU64
AASP88-LEU100
AASP132-LEU144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues802
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ILE238
APHE290-VAL317
APHE384-VAL394
AASP456-MET583
CMET1-ILE238
CPHE290-VAL317
CPHE384-VAL394
CASP456-MET583

site_idSWS_FT_FI2
Number of Residues288
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA239-LEU259
CHIS318-CYS338
CTRP363-LEU383
CSER395-ILE417
CILE435-LYS455
CLYS584-VAL604
APHE267-ASN289
AHIS318-CYS338
ATRP363-LEU383
ASER395-ILE417
AILE435-LYS455
ALYS584-VAL604
CALA239-LEU259
CPHE267-ASN289

site_idSWS_FT_FI3
Number of Residues90
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
APRO260-GLN266
ASER339-VAL362
ALYS418-ASN434
CPRO260-GLN266
CSER339-VAL362
CLYS418-ASN434

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
APHE42
CALA44
CALA49
CSER106
CLEU108
CALA138
CTHR140
CARG145
AALA44
AALA49
ASER106
ALEU108
AALA138
ATHR140
AARG145
CPHE42

site_idSWS_FT_FI5
Number of Residues18
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
ALEU70
CLEU70
CILE72
CGLY74
CPRO76
CLYS81
CPRO178
CGLN180
CTHR182
CHIS189
AILE72
AGLY74
APRO76
ALYS81
APRO178
AGLN180
ATHR182
AHIS189

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PDB entries from 2024-07-17

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