8U85

Structural Basis of Human NOX5 Activation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001819	biological_process	positive regulation of cytokine production
A	0001935	biological_process	endothelial cell proliferation
A	0005509	molecular_function	calcium ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006915	biological_process	apoptotic process
A	0006952	biological_process	defense response
A	0015252	molecular_function	proton channel activity
A	0016175	molecular_function	superoxide-generating NAD(P)H oxidase activity
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042554	biological_process	superoxide anion generation
A	0043012	biological_process	regulation of fusion of sperm to egg plasma membrane
A	0043020	cellular_component	NADPH oxidase complex
A	0046872	molecular_function	metal ion binding
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0050661	molecular_function	NADP binding
A	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
A	0061640	biological_process	cytoskeleton-dependent cytokinesis
A	0106292	molecular_function	superoxide-generating NADPH oxidase activity
A	1902600	biological_process	proton transmembrane transport
C	0001525	biological_process	angiogenesis
C	0001819	biological_process	positive regulation of cytokine production
C	0001935	biological_process	endothelial cell proliferation
C	0005509	molecular_function	calcium ion binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006915	biological_process	apoptotic process
C	0006952	biological_process	defense response
C	0015252	molecular_function	proton channel activity
C	0016175	molecular_function	superoxide-generating NAD(P)H oxidase activity
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042554	biological_process	superoxide anion generation
C	0043012	biological_process	regulation of fusion of sperm to egg plasma membrane
C	0043020	cellular_component	NADPH oxidase complex
C	0046872	molecular_function	metal ion binding
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0050661	molecular_function	NADP binding
C	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
C	0061640	biological_process	cytoskeleton-dependent cytokinesis
C	0106292	molecular_function	superoxide-generating NADPH oxidase activity
C	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSDRSGTITlqEL

Chain	Residue	Details
A	ASP52-LEU64
A	ASP88-LEU100
A	ASP132-LEU144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	248
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	364
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	74
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"22387196","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"PubMed","id":"21642394","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCA","evidences":[{"source":"PubMed","id":"22387196","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24505490","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by CaMK2 and PKC/PRKCA","evidences":[{"source":"PubMed","id":"21642394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22387196","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24505490","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CaMK2 and PKC/PRKCA","evidences":[{"source":"PubMed","id":"21642394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22387196","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24505490","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---