8U81

KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B1	0001750	cellular_component	photoreceptor outer segment
B1	0003924	molecular_function	GTPase activity
B1	0005515	molecular_function	protein binding
B1	0005737	cellular_component	cytoplasm
B1	0005765	cellular_component	lysosomal membrane
B1	0005829	cellular_component	cytosol
B1	0005834	cellular_component	heterotrimeric G-protein complex
B1	0005886	cellular_component	plasma membrane
B1	0007165	biological_process	signal transduction
B1	0007186	biological_process	G protein-coupled receptor signaling pathway
B1	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B1	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B1	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B1	0007265	biological_process	Ras protein signal transduction
B1	0008283	biological_process	cell population proliferation
B1	0016020	cellular_component	membrane
B1	0030159	molecular_function	signaling receptor complex adaptor activity
B1	0044877	molecular_function	protein-containing complex binding
B1	0045202	cellular_component	synapse
B1	0050909	biological_process	sensory perception of taste
B1	0051020	molecular_function	GTPase binding
B1	0060041	biological_process	retina development in camera-type eye
B1	0070062	cellular_component	extracellular exosome
B1	0071380	biological_process	cellular response to prostaglandin E stimulus
B1	0071870	biological_process	cellular response to catecholamine stimulus
B1	0097381	cellular_component	photoreceptor disc membrane
B1	1903561	cellular_component	extracellular vesicle
B2	0001750	cellular_component	photoreceptor outer segment
B2	0003924	molecular_function	GTPase activity
B2	0005515	molecular_function	protein binding
B2	0005737	cellular_component	cytoplasm
B2	0005765	cellular_component	lysosomal membrane
B2	0005829	cellular_component	cytosol
B2	0005834	cellular_component	heterotrimeric G-protein complex
B2	0005886	cellular_component	plasma membrane
B2	0007165	biological_process	signal transduction
B2	0007186	biological_process	G protein-coupled receptor signaling pathway
B2	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B2	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B2	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B2	0007265	biological_process	Ras protein signal transduction
B2	0008283	biological_process	cell population proliferation
B2	0016020	cellular_component	membrane
B2	0030159	molecular_function	signaling receptor complex adaptor activity
B2	0044877	molecular_function	protein-containing complex binding
B2	0045202	cellular_component	synapse
B2	0050909	biological_process	sensory perception of taste
B2	0051020	molecular_function	GTPase binding
B2	0060041	biological_process	retina development in camera-type eye
B2	0070062	cellular_component	extracellular exosome
B2	0071380	biological_process	cellular response to prostaglandin E stimulus
B2	0071870	biological_process	cellular response to catecholamine stimulus
B2	0097381	cellular_component	photoreceptor disc membrane
B2	1903561	cellular_component	extracellular vesicle
B3	0001750	cellular_component	photoreceptor outer segment
B3	0003924	molecular_function	GTPase activity
B3	0005515	molecular_function	protein binding
B3	0005737	cellular_component	cytoplasm
B3	0005765	cellular_component	lysosomal membrane
B3	0005829	cellular_component	cytosol
B3	0005834	cellular_component	heterotrimeric G-protein complex
B3	0005886	cellular_component	plasma membrane
B3	0007165	biological_process	signal transduction
B3	0007186	biological_process	G protein-coupled receptor signaling pathway
B3	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B3	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B3	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B3	0007265	biological_process	Ras protein signal transduction
B3	0008283	biological_process	cell population proliferation
B3	0016020	cellular_component	membrane
B3	0030159	molecular_function	signaling receptor complex adaptor activity
B3	0044877	molecular_function	protein-containing complex binding
B3	0045202	cellular_component	synapse
B3	0050909	biological_process	sensory perception of taste
B3	0051020	molecular_function	GTPase binding
B3	0060041	biological_process	retina development in camera-type eye
B3	0070062	cellular_component	extracellular exosome
B3	0071380	biological_process	cellular response to prostaglandin E stimulus
B3	0071870	biological_process	cellular response to catecholamine stimulus
B3	0097381	cellular_component	photoreceptor disc membrane
B3	1903561	cellular_component	extracellular vesicle
B4	0001750	cellular_component	photoreceptor outer segment
B4	0003924	molecular_function	GTPase activity
B4	0005515	molecular_function	protein binding
B4	0005737	cellular_component	cytoplasm
B4	0005765	cellular_component	lysosomal membrane
B4	0005829	cellular_component	cytosol
B4	0005834	cellular_component	heterotrimeric G-protein complex
B4	0005886	cellular_component	plasma membrane
B4	0007165	biological_process	signal transduction
B4	0007186	biological_process	G protein-coupled receptor signaling pathway
B4	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B4	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B4	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B4	0007265	biological_process	Ras protein signal transduction
B4	0008283	biological_process	cell population proliferation
B4	0016020	cellular_component	membrane
B4	0030159	molecular_function	signaling receptor complex adaptor activity
B4	0044877	molecular_function	protein-containing complex binding
B4	0045202	cellular_component	synapse
B4	0050909	biological_process	sensory perception of taste
B4	0051020	molecular_function	GTPase binding
B4	0060041	biological_process	retina development in camera-type eye
B4	0070062	cellular_component	extracellular exosome
B4	0071380	biological_process	cellular response to prostaglandin E stimulus
B4	0071870	biological_process	cellular response to catecholamine stimulus
B4	0097381	cellular_component	photoreceptor disc membrane
B4	1903561	cellular_component	extracellular vesicle
B5	0001750	cellular_component	photoreceptor outer segment
B5	0003924	molecular_function	GTPase activity
B5	0005515	molecular_function	protein binding
B5	0005737	cellular_component	cytoplasm
B5	0005765	cellular_component	lysosomal membrane
B5	0005829	cellular_component	cytosol
B5	0005834	cellular_component	heterotrimeric G-protein complex
B5	0005886	cellular_component	plasma membrane
B5	0007165	biological_process	signal transduction
B5	0007186	biological_process	G protein-coupled receptor signaling pathway
B5	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B5	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B5	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B5	0007265	biological_process	Ras protein signal transduction
B5	0008283	biological_process	cell population proliferation
B5	0016020	cellular_component	membrane
B5	0030159	molecular_function	signaling receptor complex adaptor activity
B5	0044877	molecular_function	protein-containing complex binding
B5	0045202	cellular_component	synapse
B5	0050909	biological_process	sensory perception of taste
B5	0051020	molecular_function	GTPase binding
B5	0060041	biological_process	retina development in camera-type eye
B5	0070062	cellular_component	extracellular exosome
B5	0071380	biological_process	cellular response to prostaglandin E stimulus
B5	0071870	biological_process	cellular response to catecholamine stimulus
B5	0097381	cellular_component	photoreceptor disc membrane
B5	1903561	cellular_component	extracellular vesicle
C1	0006511	biological_process	ubiquitin-dependent protein catabolic process
C1	0031625	molecular_function	ubiquitin protein ligase binding
C2	0006511	biological_process	ubiquitin-dependent protein catabolic process
C2	0031625	molecular_function	ubiquitin protein ligase binding
C3	0006511	biological_process	ubiquitin-dependent protein catabolic process
C3	0031625	molecular_function	ubiquitin protein ligase binding
C4	0006511	biological_process	ubiquitin-dependent protein catabolic process
C4	0031625	molecular_function	ubiquitin protein ligase binding
C5	0006511	biological_process	ubiquitin-dependent protein catabolic process
C5	0031625	molecular_function	ubiquitin protein ligase binding
G1	0005515	molecular_function	protein binding
G1	0005834	cellular_component	heterotrimeric G-protein complex
G1	0005886	cellular_component	plasma membrane
G1	0007165	biological_process	signal transduction
G1	0007186	biological_process	G protein-coupled receptor signaling pathway
G1	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G1	0016020	cellular_component	membrane
G1	0031681	molecular_function	G-protein beta-subunit binding
G1	0048144	biological_process	fibroblast proliferation
G1	0070062	cellular_component	extracellular exosome
G1	0071380	biological_process	cellular response to prostaglandin E stimulus
G1	0071870	biological_process	cellular response to catecholamine stimulus
G2	0005515	molecular_function	protein binding
G2	0005834	cellular_component	heterotrimeric G-protein complex
G2	0005886	cellular_component	plasma membrane
G2	0007165	biological_process	signal transduction
G2	0007186	biological_process	G protein-coupled receptor signaling pathway
G2	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G2	0016020	cellular_component	membrane
G2	0031681	molecular_function	G-protein beta-subunit binding
G2	0048144	biological_process	fibroblast proliferation
G2	0070062	cellular_component	extracellular exosome
G2	0071380	biological_process	cellular response to prostaglandin E stimulus
G2	0071870	biological_process	cellular response to catecholamine stimulus
G3	0005515	molecular_function	protein binding
G3	0005834	cellular_component	heterotrimeric G-protein complex
G3	0005886	cellular_component	plasma membrane
G3	0007165	biological_process	signal transduction
G3	0007186	biological_process	G protein-coupled receptor signaling pathway
G3	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G3	0016020	cellular_component	membrane
G3	0031681	molecular_function	G-protein beta-subunit binding
G3	0048144	biological_process	fibroblast proliferation
G3	0070062	cellular_component	extracellular exosome
G3	0071380	biological_process	cellular response to prostaglandin E stimulus
G3	0071870	biological_process	cellular response to catecholamine stimulus
G4	0005515	molecular_function	protein binding
G4	0005834	cellular_component	heterotrimeric G-protein complex
G4	0005886	cellular_component	plasma membrane
G4	0007165	biological_process	signal transduction
G4	0007186	biological_process	G protein-coupled receptor signaling pathway
G4	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G4	0016020	cellular_component	membrane
G4	0031681	molecular_function	G-protein beta-subunit binding
G4	0048144	biological_process	fibroblast proliferation
G4	0070062	cellular_component	extracellular exosome
G4	0071380	biological_process	cellular response to prostaglandin E stimulus
G4	0071870	biological_process	cellular response to catecholamine stimulus
G5	0005515	molecular_function	protein binding
G5	0005834	cellular_component	heterotrimeric G-protein complex
G5	0005886	cellular_component	plasma membrane
G5	0007165	biological_process	signal transduction
G5	0007186	biological_process	G protein-coupled receptor signaling pathway
G5	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G5	0016020	cellular_component	membrane
G5	0031681	molecular_function	G-protein beta-subunit binding
G5	0048144	biological_process	fibroblast proliferation
G5	0070062	cellular_component	extracellular exosome
G5	0071380	biological_process	cellular response to prostaglandin E stimulus
G5	0071870	biological_process	cellular response to catecholamine stimulus
K1	0005515	molecular_function	protein binding
K1	0005634	cellular_component	nucleus
K1	0005737	cellular_component	cytoplasm
K1	0005829	cellular_component	cytosol
K1	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K1	0042802	molecular_function	identical protein binding
K1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K1	0044877	molecular_function	protein-containing complex binding
K1	0051260	biological_process	protein homooligomerization
K1	0097602	molecular_function	cullin family protein binding
K2	0005515	molecular_function	protein binding
K2	0005634	cellular_component	nucleus
K2	0005737	cellular_component	cytoplasm
K2	0005829	cellular_component	cytosol
K2	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K2	0042802	molecular_function	identical protein binding
K2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K2	0044877	molecular_function	protein-containing complex binding
K2	0051260	biological_process	protein homooligomerization
K2	0097602	molecular_function	cullin family protein binding
K3	0005515	molecular_function	protein binding
K3	0005634	cellular_component	nucleus
K3	0005737	cellular_component	cytoplasm
K3	0005829	cellular_component	cytosol
K3	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K3	0042802	molecular_function	identical protein binding
K3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K3	0044877	molecular_function	protein-containing complex binding
K3	0051260	biological_process	protein homooligomerization
K3	0097602	molecular_function	cullin family protein binding
K4	0005515	molecular_function	protein binding
K4	0005634	cellular_component	nucleus
K4	0005737	cellular_component	cytoplasm
K4	0005829	cellular_component	cytosol
K4	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K4	0042802	molecular_function	identical protein binding
K4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K4	0044877	molecular_function	protein-containing complex binding
K4	0051260	biological_process	protein homooligomerization
K4	0097602	molecular_function	cullin family protein binding
K5	0005515	molecular_function	protein binding
K5	0005634	cellular_component	nucleus
K5	0005737	cellular_component	cytoplasm
K5	0005829	cellular_component	cytosol
K5	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K5	0042802	molecular_function	identical protein binding
K5	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K5	0044877	molecular_function	protein-containing complex binding
K5	0051260	biological_process	protein homooligomerization
K5	0097602	molecular_function	cullin family protein binding

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B1	LEU70-SER84
B1	ILE157-ILE171
B1	LEU285-ALA299

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
G1	ALA2
G2	ALA2
G3	ALA2
G4	ALA2
G5	ALA2

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site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212

Chain	Residue	Details
G1	SER68
G2	SER68
G3	SER68
G4	SER68
G5	SER68

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site_id	SWS_FT_FI3
Number of Residues	5
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212

Chain	Residue	Details
G1	SER68
G2	SER68
G3	SER68
G4	SER68
G5	SER68

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