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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8U81

KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
B10001750cellular_componentphotoreceptor outer segment
B10003924molecular_functionGTPase activity
B10005515molecular_functionprotein binding
B10005737cellular_componentcytoplasm
B10005765cellular_componentlysosomal membrane
B10005829cellular_componentcytosol
B10005834cellular_componentheterotrimeric G-protein complex
B10005886cellular_componentplasma membrane
B10007165biological_processsignal transduction
B10007186biological_processG protein-coupled receptor signaling pathway
B10007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B10007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B10007265biological_processRas protein signal transduction
B10016020cellular_componentmembrane
B10030159molecular_functionsignaling receptor complex adaptor activity
B10044877molecular_functionprotein-containing complex binding
B10045202cellular_componentsynapse
B10051020molecular_functionGTPase binding
B10070062cellular_componentextracellular exosome
B10071380biological_processcellular response to prostaglandin E stimulus
B10071870biological_processcellular response to catecholamine stimulus
B10097381cellular_componentphotoreceptor disc membrane
B11903561cellular_componentextracellular vesicle
B20001750cellular_componentphotoreceptor outer segment
B20003924molecular_functionGTPase activity
B20005515molecular_functionprotein binding
B20005737cellular_componentcytoplasm
B20005765cellular_componentlysosomal membrane
B20005829cellular_componentcytosol
B20005834cellular_componentheterotrimeric G-protein complex
B20005886cellular_componentplasma membrane
B20007165biological_processsignal transduction
B20007186biological_processG protein-coupled receptor signaling pathway
B20007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B20007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B20007265biological_processRas protein signal transduction
B20016020cellular_componentmembrane
B20030159molecular_functionsignaling receptor complex adaptor activity
B20044877molecular_functionprotein-containing complex binding
B20045202cellular_componentsynapse
B20051020molecular_functionGTPase binding
B20070062cellular_componentextracellular exosome
B20071380biological_processcellular response to prostaglandin E stimulus
B20071870biological_processcellular response to catecholamine stimulus
B20097381cellular_componentphotoreceptor disc membrane
B21903561cellular_componentextracellular vesicle
B30001750cellular_componentphotoreceptor outer segment
B30003924molecular_functionGTPase activity
B30005515molecular_functionprotein binding
B30005737cellular_componentcytoplasm
B30005765cellular_componentlysosomal membrane
B30005829cellular_componentcytosol
B30005834cellular_componentheterotrimeric G-protein complex
B30005886cellular_componentplasma membrane
B30007165biological_processsignal transduction
B30007186biological_processG protein-coupled receptor signaling pathway
B30007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B30007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B30007265biological_processRas protein signal transduction
B30016020cellular_componentmembrane
B30030159molecular_functionsignaling receptor complex adaptor activity
B30044877molecular_functionprotein-containing complex binding
B30045202cellular_componentsynapse
B30051020molecular_functionGTPase binding
B30070062cellular_componentextracellular exosome
B30071380biological_processcellular response to prostaglandin E stimulus
B30071870biological_processcellular response to catecholamine stimulus
B30097381cellular_componentphotoreceptor disc membrane
B31903561cellular_componentextracellular vesicle
B40001750cellular_componentphotoreceptor outer segment
B40003924molecular_functionGTPase activity
B40005515molecular_functionprotein binding
B40005737cellular_componentcytoplasm
B40005765cellular_componentlysosomal membrane
B40005829cellular_componentcytosol
B40005834cellular_componentheterotrimeric G-protein complex
B40005886cellular_componentplasma membrane
B40007165biological_processsignal transduction
B40007186biological_processG protein-coupled receptor signaling pathway
B40007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B40007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B40007265biological_processRas protein signal transduction
B40016020cellular_componentmembrane
B40030159molecular_functionsignaling receptor complex adaptor activity
B40044877molecular_functionprotein-containing complex binding
B40045202cellular_componentsynapse
B40051020molecular_functionGTPase binding
B40070062cellular_componentextracellular exosome
B40071380biological_processcellular response to prostaglandin E stimulus
B40071870biological_processcellular response to catecholamine stimulus
B40097381cellular_componentphotoreceptor disc membrane
B41903561cellular_componentextracellular vesicle
B50001750cellular_componentphotoreceptor outer segment
B50003924molecular_functionGTPase activity
B50005515molecular_functionprotein binding
B50005737cellular_componentcytoplasm
B50005765cellular_componentlysosomal membrane
B50005829cellular_componentcytosol
B50005834cellular_componentheterotrimeric G-protein complex
B50005886cellular_componentplasma membrane
B50007165biological_processsignal transduction
B50007186biological_processG protein-coupled receptor signaling pathway
B50007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B50007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B50007265biological_processRas protein signal transduction
B50016020cellular_componentmembrane
B50030159molecular_functionsignaling receptor complex adaptor activity
B50044877molecular_functionprotein-containing complex binding
B50045202cellular_componentsynapse
B50051020molecular_functionGTPase binding
B50070062cellular_componentextracellular exosome
B50071380biological_processcellular response to prostaglandin E stimulus
B50071870biological_processcellular response to catecholamine stimulus
B50097381cellular_componentphotoreceptor disc membrane
B51903561cellular_componentextracellular vesicle
C10006511biological_processubiquitin-dependent protein catabolic process
C10031625molecular_functionubiquitin protein ligase binding
C20006511biological_processubiquitin-dependent protein catabolic process
C20031625molecular_functionubiquitin protein ligase binding
C30006511biological_processubiquitin-dependent protein catabolic process
C30031625molecular_functionubiquitin protein ligase binding
C40006511biological_processubiquitin-dependent protein catabolic process
C40031625molecular_functionubiquitin protein ligase binding
C50006511biological_processubiquitin-dependent protein catabolic process
C50031625molecular_functionubiquitin protein ligase binding
G10005515molecular_functionprotein binding
G10005834cellular_componentheterotrimeric G-protein complex
G10005886cellular_componentplasma membrane
G10007165biological_processsignal transduction
G10007186biological_processG protein-coupled receptor signaling pathway
G10007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G10016020cellular_componentmembrane
G10031681molecular_functionG-protein beta-subunit binding
G10045202cellular_componentsynapse
G10070062cellular_componentextracellular exosome
G10071380biological_processcellular response to prostaglandin E stimulus
G10071870biological_processcellular response to catecholamine stimulus
G20005515molecular_functionprotein binding
G20005834cellular_componentheterotrimeric G-protein complex
G20005886cellular_componentplasma membrane
G20007165biological_processsignal transduction
G20007186biological_processG protein-coupled receptor signaling pathway
G20007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G20016020cellular_componentmembrane
G20031681molecular_functionG-protein beta-subunit binding
G20045202cellular_componentsynapse
G20070062cellular_componentextracellular exosome
G20071380biological_processcellular response to prostaglandin E stimulus
G20071870biological_processcellular response to catecholamine stimulus
G30005515molecular_functionprotein binding
G30005834cellular_componentheterotrimeric G-protein complex
G30005886cellular_componentplasma membrane
G30007165biological_processsignal transduction
G30007186biological_processG protein-coupled receptor signaling pathway
G30007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G30016020cellular_componentmembrane
G30031681molecular_functionG-protein beta-subunit binding
G30045202cellular_componentsynapse
G30070062cellular_componentextracellular exosome
G30071380biological_processcellular response to prostaglandin E stimulus
G30071870biological_processcellular response to catecholamine stimulus
G40005515molecular_functionprotein binding
G40005834cellular_componentheterotrimeric G-protein complex
G40005886cellular_componentplasma membrane
G40007165biological_processsignal transduction
G40007186biological_processG protein-coupled receptor signaling pathway
G40007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G40016020cellular_componentmembrane
G40031681molecular_functionG-protein beta-subunit binding
G40045202cellular_componentsynapse
G40070062cellular_componentextracellular exosome
G40071380biological_processcellular response to prostaglandin E stimulus
G40071870biological_processcellular response to catecholamine stimulus
G50005515molecular_functionprotein binding
G50005834cellular_componentheterotrimeric G-protein complex
G50005886cellular_componentplasma membrane
G50007165biological_processsignal transduction
G50007186biological_processG protein-coupled receptor signaling pathway
G50007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G50016020cellular_componentmembrane
G50031681molecular_functionG-protein beta-subunit binding
G50045202cellular_componentsynapse
G50070062cellular_componentextracellular exosome
G50071380biological_processcellular response to prostaglandin E stimulus
G50071870biological_processcellular response to catecholamine stimulus
K10005515molecular_functionprotein binding
K10005634cellular_componentnucleus
K10005737cellular_componentcytoplasm
K10005829cellular_componentcytosol
K10031463cellular_componentCul3-RING ubiquitin ligase complex
K10042802molecular_functionidentical protein binding
K10043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K10044877molecular_functionprotein-containing complex binding
K10051260biological_processprotein homooligomerization
K10097602molecular_functioncullin family protein binding
K20005515molecular_functionprotein binding
K20005634cellular_componentnucleus
K20005737cellular_componentcytoplasm
K20005829cellular_componentcytosol
K20031463cellular_componentCul3-RING ubiquitin ligase complex
K20042802molecular_functionidentical protein binding
K20043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K20044877molecular_functionprotein-containing complex binding
K20051260biological_processprotein homooligomerization
K20097602molecular_functioncullin family protein binding
K30005515molecular_functionprotein binding
K30005634cellular_componentnucleus
K30005737cellular_componentcytoplasm
K30005829cellular_componentcytosol
K30031463cellular_componentCul3-RING ubiquitin ligase complex
K30042802molecular_functionidentical protein binding
K30043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K30044877molecular_functionprotein-containing complex binding
K30051260biological_processprotein homooligomerization
K30097602molecular_functioncullin family protein binding
K40005515molecular_functionprotein binding
K40005634cellular_componentnucleus
K40005737cellular_componentcytoplasm
K40005829cellular_componentcytosol
K40031463cellular_componentCul3-RING ubiquitin ligase complex
K40042802molecular_functionidentical protein binding
K40043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K40044877molecular_functionprotein-containing complex binding
K40051260biological_processprotein homooligomerization
K40097602molecular_functioncullin family protein binding
K50005515molecular_functionprotein binding
K50005634cellular_componentnucleus
K50005737cellular_componentcytoplasm
K50005829cellular_componentcytosol
K50031463cellular_componentCul3-RING ubiquitin ligase complex
K50042802molecular_functionidentical protein binding
K50043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K50044877molecular_functionprotein-containing complex binding
K50051260biological_processprotein homooligomerization
K50097602molecular_functioncullin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
B1LEU70-SER84
B1ILE157-ILE171
B1LEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues510
DetailsDomain: {"description":"BTB"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues240
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues225
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues200
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues205
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues215
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues205
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues150
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues5
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues5
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues5
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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