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8U7Y

Structural Basis of Human NOX5 Activation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001819biological_processpositive regulation of cytokine production
A0001935biological_processendothelial cell proliferation
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0006952biological_processdefense response
A0015252molecular_functionproton channel activity
A0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0034220biological_processmonoatomic ion transmembrane transport
A0042554biological_processsuperoxide anion generation
A0043012biological_processregulation of fusion of sperm to egg plasma membrane
A0043020cellular_componentNADPH oxidase complex
A0046872molecular_functionmetal ion binding
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
A0061640biological_processcytoskeleton-dependent cytokinesis
A0106292molecular_functionsuperoxide-generating NADPH oxidase activity
A1902600biological_processproton transmembrane transport
B0001525biological_processangiogenesis
B0001819biological_processpositive regulation of cytokine production
B0001935biological_processendothelial cell proliferation
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006952biological_processdefense response
B0015252molecular_functionproton channel activity
B0016175molecular_functionsuperoxide-generating NAD(P)H oxidase activity
B0016491molecular_functionoxidoreductase activity
B0020037molecular_functionheme binding
B0034220biological_processmonoatomic ion transmembrane transport
B0042554biological_processsuperoxide anion generation
B0043012biological_processregulation of fusion of sperm to egg plasma membrane
B0043020cellular_componentNADPH oxidase complex
B0046872molecular_functionmetal ion binding
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050664molecular_functionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
B0061640biological_processcytoskeleton-dependent cytokinesis
B0106292molecular_functionsuperoxide-generating NADPH oxidase activity
B1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DSDRSGTITlqEL
ChainResidueDetails
AASP52-LEU64
AASP88-LEU100
AASP132-LEU144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues802
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ILE238
APHE290-VAL317
APHE384-VAL394
AASP456-MET583
BMET1-ILE238
BPHE290-VAL317
BPHE384-VAL394
BASP456-MET583

site_idSWS_FT_FI2
Number of Residues288
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AALA239-LEU259
BHIS318-CYS338
BTRP363-LEU383
BSER395-ILE417
BILE435-LYS455
BLYS584-VAL604
APHE267-ASN289
AHIS318-CYS338
ATRP363-LEU383
ASER395-ILE417
AILE435-LYS455
ALYS584-VAL604
BALA239-LEU259
BPHE267-ASN289

site_idSWS_FT_FI3
Number of Residues90
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
APRO260-GLN266
ASER339-VAL362
ALYS418-ASN434
BPRO260-GLN266
BSER339-VAL362
BLYS418-ASN434

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
APHE42
BALA44
BALA49
BSER106
BLEU108
BALA138
BTHR140
BARG145
AALA44
AALA49
ASER106
ALEU108
AALA138
ATHR140
AARG145
BPHE42

site_idSWS_FT_FI5
Number of Residues18
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
ALEU70
BLEU70
BILE72
BGLY74
BPRO76
BLYS81
BPRO178
BGLN180
BTHR182
BHIS189
AILE72
AGLY74
APRO76
ALYS81
APRO178
AGLN180
ATHR182
AHIS189

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PDB entries from 2024-07-17

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