Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U7Q

Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, octamer-centered

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0034774	cellular_component	secretory granule lumen
A	0035578	cellular_component	azurophil granule lumen
A	0046872	molecular_function	metal ion binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0034774	cellular_component	secretory granule lumen
B	0035578	cellular_component	azurophil granule lumen
B	0046872	molecular_function	metal ion binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006183	biological_process	GTP biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0034774	cellular_component	secretory granule lumen
C	0035578	cellular_component	azurophil granule lumen
C	0046872	molecular_function	metal ion binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006183	biological_process	GTP biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0034774	cellular_component	secretory granule lumen
D	0035578	cellular_component	azurophil granule lumen
D	0046872	molecular_function	metal ion binding
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006183	biological_process	GTP biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0034774	cellular_component	secretory granule lumen
E	0035578	cellular_component	azurophil granule lumen
E	0046872	molecular_function	metal ion binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006183	biological_process	GTP biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0034774	cellular_component	secretory granule lumen
F	0035578	cellular_component	azurophil granule lumen
F	0046872	molecular_function	metal ion binding
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0003676	molecular_function	nucleic acid binding
G	0003677	molecular_function	DNA binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006177	biological_process	GMP biosynthetic process
G	0006183	biological_process	GTP biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0034774	cellular_component	secretory granule lumen
G	0035578	cellular_component	azurophil granule lumen
G	0046872	molecular_function	metal ion binding
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000166	molecular_function	nucleotide binding
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006177	biological_process	GMP biosynthetic process
H	0006183	biological_process	GTP biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0034774	cellular_component	secretory granule lumen
H	0035578	cellular_component	azurophil granule lumen
H	0046872	molecular_function	metal ion binding
H	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGcGSICiT

Chain	Residue	Details
A	LEU321-THR333

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	CYS331
B	CYS331
C	CYS331
D	CYS331
E	CYS331
F	CYS331
G	CYS331
H	CYS331

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	ARG429
B	ARG429
C	ARG429
D	ARG429
E	ARG429
F	ARG429
G	ARG429
H	ARG429

site_id	SWS_FT_FI3
Number of Residues	56
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	ASP274
B	TYR411
B	GLN441
B	GLU500
B	GLY501
B	GLY502
C	ASP274
C	GLY324
C	TYR411
C	GLN441
C	GLU500
A	GLY324
C	GLY501
C	GLY502
D	ASP274
D	GLY324
D	TYR411
D	GLN441
D	GLU500
D	GLY501
D	GLY502
E	ASP274
A	TYR411
E	GLY324
E	TYR411
E	GLN441
E	GLU500
E	GLY501
E	GLY502
F	ASP274
F	GLY324
F	TYR411
F	GLN441
A	GLN441
F	GLU500
F	GLY501
F	GLY502
G	ASP274
G	GLY324
G	TYR411
G	GLN441
G	GLU500
G	GLY501
G	GLY502
A	GLU500
H	ASP274
H	GLY324
H	TYR411
H	GLN441
H	GLU500
H	GLY501
H	GLY502
A	GLY501
A	GLY502
B	ASP274
B	GLY324

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	GLY326
D	GLY326
D	GLY328
D	CYS331
E	GLY326
E	GLY328
E	CYS331
F	GLY326
F	GLY328
F	CYS331
G	GLY326
A	GLY328
G	GLY328
G	CYS331
H	GLY326
H	GLY328
H	CYS331
A	CYS331
B	GLY326
B	GLY328
B	CYS331
C	GLY326
C	GLY328
C	CYS331

site_id	SWS_FT_FI5
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	SER329
D	SER329
D	ASP364
D	GLY387
E	SER329
E	ASP364
E	GLY387
F	SER329
F	ASP364
F	GLY387
G	SER329
A	ASP364
G	ASP364
G	GLY387
H	SER329
H	ASP364
H	GLY387
A	GLY387
B	SER329
B	ASP364
B	GLY387
C	SER329
C	ASP364
C	GLY387

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER160
B	SER160
C	SER160
D	SER160
E	SER160
F	SER160
G	SER160
H	SER160

site_id	SWS_FT_FI7
Number of Residues	16
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P50096

Chain	Residue	Details
A	ARG341
E	ARG355
F	ARG341
F	ARG355
G	ARG341
G	ARG355
H	ARG341
H	ARG355
A	ARG355
B	ARG341
B	ARG355
C	ARG341
C	ARG355
D	ARG341
D	ARG355
E	ARG341

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)