Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U58

The mTORC1 cholesterol sensor LYCHOS (GPR155) with tryptophan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002181	biological_process	cytoplasmic translation
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0031503	biological_process	protein-containing complex localization
A	0031669	biological_process	cellular response to nutrient levels
A	0034198	biological_process	cellular response to amino acid starvation
A	0035556	biological_process	intracellular signal transduction
A	0038202	biological_process	TORC1 signaling
A	0045947	biological_process	negative regulation of translational initiation
A	0045948	biological_process	positive regulation of translational initiation
A	0050890	biological_process	cognition
A	0055085	biological_process	transmembrane transport
A	0061462	biological_process	protein localization to lysosome
A	0070062	cellular_component	extracellular exosome
A	0071397	biological_process	cellular response to cholesterol
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
C	0002181	biological_process	cytoplasmic translation
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0016020	cellular_component	membrane
C	0030514	biological_process	negative regulation of BMP signaling pathway
C	0031503	biological_process	protein-containing complex localization
C	0031669	biological_process	cellular response to nutrient levels
C	0034198	biological_process	cellular response to amino acid starvation
C	0035556	biological_process	intracellular signal transduction
C	0038202	biological_process	TORC1 signaling
C	0045947	biological_process	negative regulation of translational initiation
C	0045948	biological_process	positive regulation of translational initiation
C	0050890	biological_process	cognition
C	0055085	biological_process	transmembrane transport
C	0061462	biological_process	protein localization to lysosome
C	0070062	cellular_component	extracellular exosome
C	0071397	biological_process	cellular response to cholesterol
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	152
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8U5X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36007018","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39358511","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8U5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)