8U54
The mTORC1 cholesterol sensor LYCHOS (GPR155)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0016020 | cellular_component | membrane |
| A | 0030514 | biological_process | negative regulation of BMP signaling pathway |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0050890 | biological_process | cognition |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071397 | biological_process | cellular response to cholesterol |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015485 | molecular_function | cholesterol binding |
| B | 0016020 | cellular_component | membrane |
| B | 0030514 | biological_process | negative regulation of BMP signaling pathway |
| B | 0034198 | biological_process | cellular response to amino acid starvation |
| B | 0050890 | biological_process | cognition |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071397 | biological_process | cellular response to cholesterol |
| B | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 680 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE39-ALA59 | |
| A | MET347-PHE367 | |
| A | VAL382-LEU402 | |
| A | THR415-VAL435 | |
| A | ASN439-LEU459 | |
| A | VAL481-ILE501 | |
| A | MET521-CYS541 | |
| A | LEU661-PHE681 | |
| A | LEU692-GLY712 | |
| B | ILE39-ALA59 | |
| B | PHE80-TRP100 | |
| A | PHE80-TRP100 | |
| B | SER105-ALA125 | |
| B | ALA134-VAL154 | |
| B | TYR168-CYS188 | |
| B | VAL214-ASP234 | |
| B | PHE244-MET264 | |
| B | SER274-CYS294 | |
| B | TYR316-PHE336 | |
| B | MET347-PHE367 | |
| B | VAL382-LEU402 | |
| B | THR415-VAL435 | |
| A | SER105-ALA125 | |
| B | ASN439-LEU459 | |
| B | VAL481-ILE501 | |
| B | MET521-CYS541 | |
| B | LEU661-PHE681 | |
| B | LEU692-GLY712 | |
| A | ALA134-VAL154 | |
| A | TYR168-CYS188 | |
| A | VAL214-ASP234 | |
| A | PHE244-MET264 | |
| A | SER274-CYS294 | |
| A | TYR316-PHE336 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:36007018 |
| Chain | Residue | Details |
| A | PHE43 | |
| A | TYR57 | |
| B | PHE43 | |
| B | TYR57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN9 | |
| B | ASN15 | |
| B | ASN29 | |
| B | ASN198 | |
| B | ASN309 | |
| B | ASN381 | |
| B | ASN543 | |
| B | ASN612 | |
| A | ASN15 | |
| A | ASN29 | |
| A | ASN198 | |
| A | ASN309 | |
| A | ASN381 | |
| A | ASN543 | |
| A | ASN612 | |
| B | ASN9 |
