8U4W
The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+-protein poly-ADP-ribosyltransferase activity |
| B | 0003950 | molecular_function | NAD+-protein poly-ADP-ribosyltransferase activity |
| C | 0003950 | molecular_function | NAD+-protein poly-ADP-ribosyltransferase activity |
| D | 0003950 | molecular_function | NAD+-protein poly-ADP-ribosyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 |
| Chain | Residue | Details |
| A | GLU988 | |
| B | GLU988 | |
| C | GLU988 | |
| D | GLU988 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UGN5 |
| Chain | Residue | Details |
| A | HIS862 | |
| C | GLY871 | |
| C | ARG878 | |
| C | SER904 | |
| D | HIS862 | |
| D | GLY871 | |
| D | ARG878 | |
| D | SER904 | |
| A | GLY871 | |
| A | ARG878 | |
| A | SER904 | |
| B | HIS862 | |
| B | GLY871 | |
| B | ARG878 | |
| B | SER904 | |
| C | HIS862 |
