8U4L

Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005102	molecular_function	signaling receptor binding
C	0007399	biological_process	nervous system development

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCpnEftGDrC

Chain	Residue	Details
C	CYS210-CYS221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR182
A	ASN174
A	ASN253
A	ASN358
A	ASN410
A	ASN473
A	ASN495
A	ASN576

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW

Chain	Residue	Details
B	ASN68
A	ASN548
A	ASN620

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN124
B	ASN629

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85

Chain	Residue	Details
B	ASN187

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0000269|PubMed:20696930, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW, ECO:0007744|PDB:3N85

Chain	Residue	Details
B	ASN259

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0007744|PDB:1S78

Chain	Residue	Details
B	ASN530

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:3MZW

Chain	Residue	Details
B	ASN571

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