Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8U3Z

Model of TTLL6 bound to microtubule from composite map

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0051301	biological_process	cell division
A	0071353	biological_process	cellular response to interleukin-4
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005198	molecular_function	structural molecule activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005641	cellular_component	nuclear envelope lumen
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0019904	molecular_function	protein domain specific binding
B	0030705	biological_process	cytoskeleton-dependent intracellular transport
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032794	molecular_function	GTPase activating protein binding
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042267	biological_process	natural killer cell mediated cytotoxicity
B	0042288	molecular_function	MHC class I protein binding
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0050807	biological_process	regulation of synapse organization
B	0051225	biological_process	spindle assembly
B	0051301	biological_process	cell division
B	0070062	cellular_component	extracellular exosome
B	0071895	biological_process	odontoblast differentiation
B	0072686	cellular_component	mitotic spindle
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003924	molecular_function	GTPase activity
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005641	cellular_component	nuclear envelope lumen
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0019904	molecular_function	protein domain specific binding
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032794	molecular_function	GTPase activating protein binding
E	0032991	cellular_component	protein-containing complex
E	0035578	cellular_component	azurophil granule lumen
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042267	biological_process	natural killer cell mediated cytotoxicity
E	0042288	molecular_function	MHC class I protein binding
E	0044297	cellular_component	cell body
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0045171	cellular_component	intercellular bridge
E	0046872	molecular_function	metal ion binding
E	0050807	biological_process	regulation of synapse organization
E	0051225	biological_process	spindle assembly
E	0051301	biological_process	cell division
E	0070062	cellular_component	extracellular exosome
E	0071895	biological_process	odontoblast differentiation
E	0072686	cellular_component	mitotic spindle
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003725	molecular_function	double-stranded RNA binding
F	0003924	molecular_function	GTPase activity
F	0005198	molecular_function	structural molecule activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005881	cellular_component	cytoplasmic microtubule
F	0007017	biological_process	microtubule-based process
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0030705	biological_process	cytoskeleton-dependent intracellular transport
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0051301	biological_process	cell division
F	0071353	biological_process	cellular response to interleukin-4
N	0001578	biological_process	microtubule bundle formation
N	0003353	biological_process	positive regulation of cilium movement
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0005929	cellular_component	cilium
N	0015631	molecular_function	tubulin binding
N	0016874	molecular_function	ligase activity
N	0018095	biological_process	protein polyglutamylation
N	0036064	cellular_component	ciliary basal body
N	0036211	biological_process	protein modification process
N	0046872	molecular_function	metal ion binding
N	0051013	biological_process	microtubule severing
N	0060296	biological_process	regulation of cilium beat frequency involved in ciliary motility
N	0070739	molecular_function	protein-glutamic acid ligase activity
N	0070740	molecular_function	tubulin-glutamic acid ligase activity
N	0097731	cellular_component	9+0 non-motile cilium
N	0106437	molecular_function	protein-glutamic acid ligase activity, initiating
N	0106438	molecular_function	protein-glutamic acid ligase activity, elongating

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:32747782, ECO:0007744\|PDB:6VZT

Chain	Residue	Details
N	LYS174
E	GLY142
E	THR143
E	GLY144
E	ASN204
E	ASN226
N	GLN202
N	LYS215
N	THR263
B	GLY144
B	ASN204
B	ASN226
E	GLN11
E	SER138

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:32747782

Chain	Residue	Details
N	GLN180
F	GLU71
F	SER140
F	GLY144
F	THR145
F	THR179
F	ASN206
F	ASN228
N	HIS362
A	SER140
A	GLY144
A	THR145
A	THR179
A	ASN206
A	ASN228
F	GLN11

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000305\|PubMed:32747782, ECO:0007744\|PDB:6VZU, ECO:0007744\|PDB:6VZW

Chain	Residue	Details
N	ARG241
N	TYR265
N	SER266
N	LYS283
N	LYS377

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:32747782, ECO:0007744\|PDB:6VZU

Chain	Residue	Details
N	ASP346
N	GLU359
N	ASN361
E	THR55
E	THR285
E	THR290

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
N	GLN180
E	LYS58
F	SER48
F	SER232

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Important for specifying alpha-elongation versus initiation step of the polyglutamylase activity => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
N	HIS362
E	SER172

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|Ref.9

Chain	Residue	Details
B	ARG318
E	ARG318

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:28576883

Chain	Residue	Details
B	GLU434
B	GLU441
E	GLU434
E	GLU441

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
B	GLU438
B	GLU439
E	GLU438
E	GLU439

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: 5-glutamyl glycine => ECO:0000269\|PubMed:28576883

Chain	Residue	Details
B	GLU442
B	GLU443
E	GLU442
E	GLU443

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
B	LYS58
E	LYS58

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
A	LYS326
B	LYS324
A	LYS370
E	LYS324
F	LYS370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)