8U3Z
Model of TTLL6 bound to microtubule from composite map
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005198 | molecular_function | structural molecule activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0005929 | cellular_component | cilium |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0030182 | biological_process | neuron differentiation |
| A | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0051301 | biological_process | cell division |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005641 | cellular_component | nuclear envelope lumen |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0005929 | cellular_component | cilium |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032794 | molecular_function | GTPase activating protein binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| B | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| B | 0042288 | molecular_function | MHC class I protein binding |
| B | 0044297 | cellular_component | cell body |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045121 | cellular_component | membrane raft |
| B | 0045171 | cellular_component | intercellular bridge |
| B | 0050807 | biological_process | regulation of synapse organization |
| B | 0051301 | biological_process | cell division |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071895 | biological_process | odontoblast differentiation |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 0097228 | cellular_component | sperm principal piece |
| B | 0097229 | cellular_component | sperm end piece |
| B | 0097542 | cellular_component | ciliary tip |
| E | 0000278 | biological_process | mitotic cell cycle |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005198 | molecular_function | structural molecule activity |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005515 | molecular_function | protein binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005634 | cellular_component | nucleus |
| E | 0005641 | cellular_component | nuclear envelope lumen |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005874 | cellular_component | microtubule |
| E | 0005929 | cellular_component | cilium |
| E | 0007010 | biological_process | cytoskeleton organization |
| E | 0007017 | biological_process | microtubule-based process |
| E | 0015630 | cellular_component | microtubule cytoskeleton |
| E | 0019904 | molecular_function | protein domain specific binding |
| E | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| E | 0031625 | molecular_function | ubiquitin protein ligase binding |
| E | 0032794 | molecular_function | GTPase activating protein binding |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0035578 | cellular_component | azurophil granule lumen |
| E | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| E | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| E | 0042288 | molecular_function | MHC class I protein binding |
| E | 0044297 | cellular_component | cell body |
| E | 0044877 | molecular_function | protein-containing complex binding |
| E | 0045121 | cellular_component | membrane raft |
| E | 0045171 | cellular_component | intercellular bridge |
| E | 0050807 | biological_process | regulation of synapse organization |
| E | 0051301 | biological_process | cell division |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071895 | biological_process | odontoblast differentiation |
| E | 0072686 | cellular_component | mitotic spindle |
| E | 0097228 | cellular_component | sperm principal piece |
| E | 0097229 | cellular_component | sperm end piece |
| E | 0097542 | cellular_component | ciliary tip |
| F | 0000226 | biological_process | microtubule cytoskeleton organization |
| F | 0000278 | biological_process | mitotic cell cycle |
| F | 0003725 | molecular_function | double-stranded RNA binding |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005198 | molecular_function | structural molecule activity |
| F | 0005200 | molecular_function | structural constituent of cytoskeleton |
| F | 0005515 | molecular_function | protein binding |
| F | 0005525 | molecular_function | GTP binding |
| F | 0005856 | cellular_component | cytoskeleton |
| F | 0005874 | cellular_component | microtubule |
| F | 0005881 | cellular_component | cytoplasmic microtubule |
| F | 0005929 | cellular_component | cilium |
| F | 0007017 | biological_process | microtubule-based process |
| F | 0015630 | cellular_component | microtubule cytoskeleton |
| F | 0030182 | biological_process | neuron differentiation |
| F | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| F | 0031625 | molecular_function | ubiquitin protein ligase binding |
| F | 0051301 | biological_process | cell division |
| N | 0001578 | biological_process | microtubule bundle formation |
| N | 0003353 | biological_process | positive regulation of cilium movement |
| N | 0005515 | molecular_function | protein binding |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0005814 | cellular_component | centriole |
| N | 0005856 | cellular_component | cytoskeleton |
| N | 0005929 | cellular_component | cilium |
| N | 0005930 | cellular_component | axoneme |
| N | 0015630 | cellular_component | microtubule cytoskeleton |
| N | 0015631 | molecular_function | tubulin binding |
| N | 0018095 | biological_process | protein polyglutamylation |
| N | 0036064 | cellular_component | ciliary basal body |
| N | 0036211 | biological_process | protein modification process |
| N | 0051013 | biological_process | microtubule severing |
| N | 0060296 | biological_process | regulation of cilium beat frequency involved in ciliary motility |
| N | 0070739 | molecular_function | protein-glutamic acid ligase activity |
| N | 0070740 | molecular_function | tubulin-glutamic acid ligase activity |
| N | 0097225 | cellular_component | sperm midpiece |
| N | 0097228 | cellular_component | sperm principal piece |
| N | 0097229 | cellular_component | sperm end piece |
| N | 0097731 | cellular_component | 9+0 non-motile cilium |
| N | 0106437 | molecular_function | protein-glutamic acid ligase activity, initiating |
| N | 0106438 | molecular_function | protein-glutamic acid ligase activity, elongating |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Motif: {"description":"MREI motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Campbell A.","Ozanne B.W.","Lourenco F.","Olson M.F."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 343 |
| Details | Domain: {"description":"TTL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00568","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 79 |
| Details | Region: {"description":"c-MTBD region","evidences":[{"source":"UniProtKB","id":"Q8N841","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VZW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for specifying alpha-elongation versus initiation step of the polyglutamylase activity","evidences":[{"source":"PubMed","id":"32747782","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
