8TW7

Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000076	biological_process	DNA replication checkpoint signaling
2	0000077	biological_process	DNA damage checkpoint signaling
2	0000166	molecular_function	nucleotide binding
2	0003677	molecular_function	DNA binding
2	0003689	molecular_function	DNA clamp loader activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005663	cellular_component	DNA replication factor C complex
2	0006260	biological_process	DNA replication
2	0006261	biological_process	DNA-templated DNA replication
2	0006271	biological_process	DNA strand elongation involved in DNA replication
2	0006272	biological_process	leading strand elongation
2	0006281	biological_process	DNA repair
2	0006298	biological_process	mismatch repair
2	0007062	biological_process	sister chromatid cohesion
2	0007064	biological_process	mitotic sister chromatid cohesion
2	0016887	molecular_function	ATP hydrolysis activity
2	0031389	cellular_component	Rad17 RFC-like complex
2	0031390	cellular_component	Ctf18 RFC-like complex
2	0031391	cellular_component	Elg1 RFC-like complex
3	0000077	biological_process	DNA damage checkpoint signaling
3	0000166	molecular_function	nucleotide binding
3	0003677	molecular_function	DNA binding
3	0003689	molecular_function	DNA clamp loader activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005663	cellular_component	DNA replication factor C complex
3	0005829	cellular_component	cytosol
3	0006260	biological_process	DNA replication
3	0006261	biological_process	DNA-templated DNA replication
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006272	biological_process	leading strand elongation
3	0006281	biological_process	DNA repair
3	0006298	biological_process	mismatch repair
3	0007064	biological_process	mitotic sister chromatid cohesion
3	0016887	molecular_function	ATP hydrolysis activity
3	0031389	cellular_component	Rad17 RFC-like complex
3	0031390	cellular_component	Ctf18 RFC-like complex
3	0031391	cellular_component	Elg1 RFC-like complex
4	0000077	biological_process	DNA damage checkpoint signaling
4	0000166	molecular_function	nucleotide binding
4	0003677	molecular_function	DNA binding
4	0003689	molecular_function	DNA clamp loader activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005663	cellular_component	DNA replication factor C complex
4	0005829	cellular_component	cytosol
4	0006260	biological_process	DNA replication
4	0006261	biological_process	DNA-templated DNA replication
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006272	biological_process	leading strand elongation
4	0006281	biological_process	DNA repair
4	0007062	biological_process	sister chromatid cohesion
4	0007064	biological_process	mitotic sister chromatid cohesion
4	0016887	molecular_function	ATP hydrolysis activity
4	0031389	cellular_component	Rad17 RFC-like complex
4	0031390	cellular_component	Ctf18 RFC-like complex
4	0031391	cellular_component	Elg1 RFC-like complex
5	0000077	biological_process	DNA damage checkpoint signaling
5	0000166	molecular_function	nucleotide binding
5	0003677	molecular_function	DNA binding
5	0003689	molecular_function	DNA clamp loader activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005663	cellular_component	DNA replication factor C complex
5	0006260	biological_process	DNA replication
5	0006261	biological_process	DNA-templated DNA replication
5	0006271	biological_process	DNA strand elongation involved in DNA replication
5	0006272	biological_process	leading strand elongation
5	0006281	biological_process	DNA repair
5	0007062	biological_process	sister chromatid cohesion
5	0007064	biological_process	mitotic sister chromatid cohesion
5	0031389	cellular_component	Rad17 RFC-like complex
5	0031390	cellular_component	Ctf18 RFC-like complex
5	0031391	cellular_component	Elg1 RFC-like complex
A	0000278	biological_process	mitotic cell cycle
A	0000710	biological_process	meiotic mismatch repair
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005657	cellular_component	replication fork
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006273	biological_process	lagging strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006301	biological_process	postreplication repair
A	0006974	biological_process	DNA damage response
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0019985	biological_process	translesion synthesis
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0034087	biological_process	establishment of mitotic sister chromatid cohesion
A	0035753	biological_process	maintenance of DNA trinucleotide repeats
A	0042802	molecular_function	identical protein binding
A	0043626	cellular_component	PCNA complex
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0051054	biological_process	positive regulation of DNA metabolic process
A	0070987	biological_process	error-free translesion synthesis
B	0000278	biological_process	mitotic cell cycle
B	0000710	biological_process	meiotic mismatch repair
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005657	cellular_component	replication fork
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006273	biological_process	lagging strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006301	biological_process	postreplication repair
B	0006974	biological_process	DNA damage response
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0019985	biological_process	translesion synthesis
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0030466	biological_process	silent mating-type cassette heterochromatin formation
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0034087	biological_process	establishment of mitotic sister chromatid cohesion
B	0035753	biological_process	maintenance of DNA trinucleotide repeats
B	0042802	molecular_function	identical protein binding
B	0043626	cellular_component	PCNA complex
B	0045739	biological_process	positive regulation of DNA repair
B	0045740	biological_process	positive regulation of DNA replication
B	0051054	biological_process	positive regulation of DNA metabolic process
B	0070987	biological_process	error-free translesion synthesis
C	0000278	biological_process	mitotic cell cycle
C	0000710	biological_process	meiotic mismatch repair
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005657	cellular_component	replication fork
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006273	biological_process	lagging strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006301	biological_process	postreplication repair
C	0006974	biological_process	DNA damage response
C	0007064	biological_process	mitotic sister chromatid cohesion
C	0019985	biological_process	translesion synthesis
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0030466	biological_process	silent mating-type cassette heterochromatin formation
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0034087	biological_process	establishment of mitotic sister chromatid cohesion
C	0035753	biological_process	maintenance of DNA trinucleotide repeats
C	0042802	molecular_function	identical protein binding
C	0043626	cellular_component	PCNA complex
C	0045739	biological_process	positive regulation of DNA repair
C	0045740	biological_process	positive regulation of DNA replication
C	0051054	biological_process	positive regulation of DNA metabolic process
C	0070987	biological_process	error-free translesion synthesis

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDHpvtLgmdLtSLsKIL

Chain	Residue	Details
A	ARG61-LEU79

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site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIiAqAVDdSRVlLVsLeIgveaF

Chain	Residue	Details
A	GLY34-PHE57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA_BIND: DNA_BIND => ECO:0000255

Chain	Residue	Details
A	ARG61-ARG80
B	ARG61-ARG80
C	ARG61-ARG80
2	ASN171
2	ARG229
3	ARG206

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site_id	SWS_FT_FI2
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15166219

Chain	Residue	Details
A	LYS127
B	LYS127
C	LYS127

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:12226657

Chain	Residue	Details
A	LYS164
B	LYS164
C	LYS164

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