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8TTQ

Cryo-EM structure of the inner MKLN1 dimer from an autoinhibited MKLN1 tetramer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000151cellular_componentubiquitin ligase complex
A0001726cellular_componentruffle
A0002090biological_processregulation of receptor internalization
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007160biological_processcell-matrix adhesion
A0007165biological_processsignal transduction
A0008360biological_processregulation of cell shape
A0030036biological_processactin cytoskeleton organization
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045202cellular_componentsynapse
A0098794cellular_componentpostsynapse
A0098895cellular_componentpostsynaptic endosome membrane
A0098968biological_processneurotransmitter receptor transport postsynaptic membrane to endosome
A0098982cellular_componentGABA-ergic synapse
A0099164cellular_componentpostsynaptic specialization membrane of symmetric synapse
B0000151cellular_componentubiquitin ligase complex
B0001726cellular_componentruffle
B0002090biological_processregulation of receptor internalization
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005938cellular_componentcell cortex
B0007160biological_processcell-matrix adhesion
B0007165biological_processsignal transduction
B0008360biological_processregulation of cell shape
B0030036biological_processactin cytoskeleton organization
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045202cellular_componentsynapse
B0098794cellular_componentpostsynapse
B0098895cellular_componentpostsynaptic endosome membrane
B0098968biological_processneurotransmitter receptor transport postsynaptic membrane to endosome
B0098982cellular_componentGABA-ergic synapse
B0099164cellular_componentpostsynaptic specialization membrane of symmetric synapse
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues64
DetailsDomain: {"description":"LisH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00126","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues92
DetailsRepeat: {"description":"Kelch 1"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues104
DetailsRepeat: {"description":"Kelch 2"}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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