8TRG

Structure of full-length LexA bound to a RecA filament

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000725	biological_process	recombinational repair
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0009432	biological_process	SOS response
A	0010212	biological_process	response to ionizing radiation
A	0019985	biological_process	translesion synthesis
A	0035825	biological_process	homologous recombination
A	0048870	biological_process	cell motility
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	0000166	molecular_function	nucleotide binding
B	0000725	biological_process	recombinational repair
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0009432	biological_process	SOS response
B	0010212	biological_process	response to ionizing radiation
B	0019985	biological_process	translesion synthesis
B	0035825	biological_process	homologous recombination
B	0048870	biological_process	cell motility
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
C	0000166	molecular_function	nucleotide binding
C	0000725	biological_process	recombinational repair
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006259	biological_process	DNA metabolic process
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0009432	biological_process	SOS response
C	0010212	biological_process	response to ionizing radiation
C	0019985	biological_process	translesion synthesis
C	0035825	biological_process	homologous recombination
C	0048870	biological_process	cell motility
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity
D	0000166	molecular_function	nucleotide binding
D	0000725	biological_process	recombinational repair
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006259	biological_process	DNA metabolic process
D	0006281	biological_process	DNA repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0009432	biological_process	SOS response
D	0010212	biological_process	response to ionizing radiation
D	0019985	biological_process	translesion synthesis
D	0035825	biological_process	homologous recombination
D	0048870	biological_process	cell motility
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000166	molecular_function	nucleotide binding
E	0000725	biological_process	recombinational repair
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006259	biological_process	DNA metabolic process
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0006974	biological_process	DNA damage response
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0009432	biological_process	SOS response
E	0010212	biological_process	response to ionizing radiation
E	0019985	biological_process	translesion synthesis
E	0035825	biological_process	homologous recombination
E	0048870	biological_process	cell motility
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
F	0000166	molecular_function	nucleotide binding
F	0000725	biological_process	recombinational repair
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006259	biological_process	DNA metabolic process
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0006974	biological_process	DNA damage response
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0009432	biological_process	SOS response
F	0010212	biological_process	response to ionizing radiation
F	0019985	biological_process	translesion synthesis
F	0035825	biological_process	homologous recombination
F	0048870	biological_process	cell motility
F	0140297	molecular_function	DNA-binding transcription factor binding
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity
G	0000166	molecular_function	nucleotide binding
G	0000725	biological_process	recombinational repair
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006259	biological_process	DNA metabolic process
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0006974	biological_process	DNA damage response
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0009432	biological_process	SOS response
G	0010212	biological_process	response to ionizing radiation
G	0019985	biological_process	translesion synthesis
G	0035825	biological_process	homologous recombination
G	0048870	biological_process	cell motility
G	0140297	molecular_function	DNA-binding transcription factor binding
G	0140664	molecular_function	ATP-dependent DNA damage sensor activity
H	0000166	molecular_function	nucleotide binding
H	0000725	biological_process	recombinational repair
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006259	biological_process	DNA metabolic process
H	0006281	biological_process	DNA repair
H	0006310	biological_process	DNA recombination
H	0006974	biological_process	DNA damage response
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0009432	biological_process	SOS response
H	0010212	biological_process	response to ionizing radiation
H	0019985	biological_process	translesion synthesis
H	0035825	biological_process	homologous recombination
H	0048870	biological_process	cell motility
H	0140297	molecular_function	DNA-binding transcription factor binding
H	0140664	molecular_function	ATP-dependent DNA damage sensor activity
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0001217	molecular_function	DNA-binding transcription repressor activity
I	0003677	molecular_function	DNA binding
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0006260	biological_process	DNA replication
I	0006281	biological_process	DNA repair
I	0006351	biological_process	DNA-templated transcription
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006508	biological_process	proteolysis
I	0006974	biological_process	DNA damage response
I	0009432	biological_process	SOS response
I	0016787	molecular_function	hydrolase activity
I	0032993	cellular_component	protein-DNA complex
I	0042802	molecular_function	identical protein binding
I	0043565	molecular_function	sequence-specific DNA binding
I	0045892	biological_process	negative regulation of DNA-templated transcription
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0001217	molecular_function	DNA-binding transcription repressor activity
J	0003677	molecular_function	DNA binding
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0006260	biological_process	DNA replication
J	0006281	biological_process	DNA repair
J	0006351	biological_process	DNA-templated transcription
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006508	biological_process	proteolysis
J	0006974	biological_process	DNA damage response
J	0009432	biological_process	SOS response
J	0016787	molecular_function	hydrolase activity
J	0032993	cellular_component	protein-DNA complex
J	0042802	molecular_function	identical protein binding
J	0043565	molecular_function	sequence-specific DNA binding
J	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00321
Number of Residues	9
Details	RECA_1 recA signature. ALKFYASVR

Chain	Residue	Details
A	ALA214-ARG222

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00268","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1731253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"For autocatalytic cleavage activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by autolysis"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 724

Chain	Residue	Details
I	MET118	electrostatic stabiliser
I	SER119	electrostatic stabiliser
I	GLU152	electrostatic stabiliser
I	ALA156	proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 724

Chain	Residue	Details
J	MET118	electrostatic stabiliser
J	SER119	electrostatic stabiliser
J	GLU152	electrostatic stabiliser
J	ALA156	proton acceptor, proton donor

---