8TOH

Cryo-EM structure of monomeric alpha-Klotho

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003085	biological_process	negative regulation of systemic arterial blood pressure
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004566	molecular_function	beta-glucuronidase activity
A	0005104	molecular_function	fibroblast growth factor receptor binding
A	0005179	molecular_function	hormone activity
A	0005499	molecular_function	vitamin D binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0008422	molecular_function	beta-glucosidase activity
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0014823	biological_process	response to activity
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0017134	molecular_function	fibroblast growth factor binding
A	0030501	biological_process	positive regulation of bone mineralization
A	0033280	biological_process	response to vitamin D
A	0042421	biological_process	norepinephrine biosynthetic process
A	0070062	cellular_component	extracellular exosome
A	0071774	biological_process	response to fibroblast growth factor
A	1990776	biological_process	response to angiotensin

Functional Information from PROSITE/UniProt

site_id	PS00653
Number of Residues	15
Details	GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWAvGsAAYQtEgG

Chain	Residue	Details
A	PHE65-GLY79

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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