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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TMB

Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C12 and 20 mM MgCl2, State MG20-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006824biological_processcobalt ion transport
A0015087molecular_functioncobalt ion transmembrane transporter activity
A0015095molecular_functionmagnesium ion transmembrane transporter activity
A0015693biological_processmagnesium ion transport
A0016020cellular_componentmembrane
A0030001biological_processmetal ion transport
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0046873molecular_functionmetal ion transmembrane transporter activity
A0050897molecular_functioncobalt ion binding
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A1903830biological_processmagnesium ion transmembrane transport
B0000287molecular_functionmagnesium ion binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006824biological_processcobalt ion transport
B0015087molecular_functioncobalt ion transmembrane transporter activity
B0015095molecular_functionmagnesium ion transmembrane transporter activity
B0015693biological_processmagnesium ion transport
B0016020cellular_componentmembrane
B0030001biological_processmetal ion transport
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0046873molecular_functionmetal ion transmembrane transporter activity
B0050897molecular_functioncobalt ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B1903830biological_processmagnesium ion transmembrane transport
C0000287molecular_functionmagnesium ion binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006824biological_processcobalt ion transport
C0015087molecular_functioncobalt ion transmembrane transporter activity
C0015095molecular_functionmagnesium ion transmembrane transporter activity
C0015693biological_processmagnesium ion transport
C0016020cellular_componentmembrane
C0030001biological_processmetal ion transport
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0046873molecular_functionmetal ion transmembrane transporter activity
C0050897molecular_functioncobalt ion binding
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
C1903830biological_processmagnesium ion transmembrane transport
D0000287molecular_functionmagnesium ion binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006824biological_processcobalt ion transport
D0015087molecular_functioncobalt ion transmembrane transporter activity
D0015095molecular_functionmagnesium ion transmembrane transporter activity
D0015693biological_processmagnesium ion transport
D0016020cellular_componentmembrane
D0030001biological_processmetal ion transport
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0046873molecular_functionmetal ion transmembrane transporter activity
D0050897molecular_functioncobalt ion binding
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D1903830biological_processmagnesium ion transmembrane transport
E0000287molecular_functionmagnesium ion binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006824biological_processcobalt ion transport
E0015087molecular_functioncobalt ion transmembrane transporter activity
E0015095molecular_functionmagnesium ion transmembrane transporter activity
E0015693biological_processmagnesium ion transport
E0016020cellular_componentmembrane
E0030001biological_processmetal ion transport
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0046873molecular_functionmetal ion transmembrane transporter activity
E0050897molecular_functioncobalt ion binding
E0051260biological_processprotein homooligomerization
E0055085biological_processtransmembrane transport
E1903830biological_processmagnesium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR193-HIS199
HTYR214-HIS220
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23112165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26871634","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues50
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues607
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues235
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsMotif: {"description":"Probable selectivity filter","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23781956","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues5
DetailsSite: {"description":"Essential for ion permeation","evidences":[{"source":"PubMed","id":"23091000","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsSite: {"description":"Important for closing the ion permeation pathway in the closed state","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18276588","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues5
DetailsSite: {"description":"Threonine that confers selectivity for Co(2+) transport","evidences":[{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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