Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8TKD

Human Type 3 IP3 Receptor - Preactivated State (+IP3/ATP)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0005216molecular_functionmonoatomic ion channel activity
A0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007613biological_processmemory
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030168biological_processplatelet activation
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031095cellular_componentplatelet dense tubular network membrane
A0031410cellular_componentcytoplasmic vesicle
A0035091molecular_functionphosphatidylinositol binding
A0043025cellular_componentneuronal cell body
A0043235cellular_componentreceptor complex
A0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
A0045177cellular_componentapical part of cell
A0050909biological_processsensory perception of taste
A0050913biological_processsensory perception of bitter taste
A0050916biological_processsensory perception of sweet taste
A0050917biological_processsensory perception of umami taste
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0051592biological_processresponse to calcium ion
A0055074biological_processcalcium ion homeostasis
A0055085biological_processtransmembrane transport
A0060291biological_processlong-term synaptic potentiation
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
B0000822molecular_functioninositol hexakisphosphate binding
B0005216molecular_functionmonoatomic ion channel activity
B0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007613biological_processmemory
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030168biological_processplatelet activation
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031095cellular_componentplatelet dense tubular network membrane
B0031410cellular_componentcytoplasmic vesicle
B0035091molecular_functionphosphatidylinositol binding
B0043025cellular_componentneuronal cell body
B0043235cellular_componentreceptor complex
B0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
B0045177cellular_componentapical part of cell
B0050909biological_processsensory perception of taste
B0050913biological_processsensory perception of bitter taste
B0050916biological_processsensory perception of sweet taste
B0050917biological_processsensory perception of umami taste
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0051592biological_processresponse to calcium ion
B0055074biological_processcalcium ion homeostasis
B0055085biological_processtransmembrane transport
B0060291biological_processlong-term synaptic potentiation
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
C0000822molecular_functioninositol hexakisphosphate binding
C0005216molecular_functionmonoatomic ion channel activity
C0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007613biological_processmemory
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030168biological_processplatelet activation
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0031095cellular_componentplatelet dense tubular network membrane
C0031410cellular_componentcytoplasmic vesicle
C0035091molecular_functionphosphatidylinositol binding
C0043025cellular_componentneuronal cell body
C0043235cellular_componentreceptor complex
C0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
C0045177cellular_componentapical part of cell
C0050909biological_processsensory perception of taste
C0050913biological_processsensory perception of bitter taste
C0050916biological_processsensory perception of sweet taste
C0050917biological_processsensory perception of umami taste
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0051592biological_processresponse to calcium ion
C0055074biological_processcalcium ion homeostasis
C0055085biological_processtransmembrane transport
C0060291biological_processlong-term synaptic potentiation
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
D0000822molecular_functioninositol hexakisphosphate binding
D0005216molecular_functionmonoatomic ion channel activity
D0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007186biological_processG protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007613biological_processmemory
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030168biological_processplatelet activation
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031095cellular_componentplatelet dense tubular network membrane
D0031410cellular_componentcytoplasmic vesicle
D0035091molecular_functionphosphatidylinositol binding
D0043025cellular_componentneuronal cell body
D0043235cellular_componentreceptor complex
D0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
D0045177cellular_componentapical part of cell
D0050909biological_processsensory perception of taste
D0050913biological_processsensory perception of bitter taste
D0050916biological_processsensory perception of sweet taste
D0050917biological_processsensory perception of umami taste
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0051592biological_processresponse to calcium ion
D0055074biological_processcalcium ion homeostasis
D0055085biological_processtransmembrane transport
D0060291biological_processlong-term synaptic potentiation
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. LSVVLDT
ChainResidueDetails
ALEU1469-THR1475

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9528
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-THR2202
CLYS2257-LEU2264
CASP2347-SER2368
CASP2518-ARG2671
DMET1-THR2202
DLYS2257-LEU2264
DASP2347-SER2368
DASP2518-ARG2671
ALYS2257-LEU2264
AASP2347-SER2368
AASP2518-ARG2671
BMET1-THR2202
BLYS2257-LEU2264
BASP2347-SER2368
BASP2518-ARG2671
CMET1-THR2202

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU2203-TYR2223
BTYR2326-PHE2346
BILE2369-LEU2389
BASP2497-ILE2517
CLEU2203-TYR2223
CSER2236-THR2256
CILE2265-LEU2285
CTYR2326-PHE2346
CILE2369-LEU2389
CASP2497-ILE2517
DLEU2203-TYR2223
ASER2236-THR2256
DSER2236-THR2256
DILE2265-LEU2285
DTYR2326-PHE2346
DILE2369-LEU2389
DASP2497-ILE2517
AILE2265-LEU2285
ATYR2326-PHE2346
AILE2369-LEU2389
AASP2497-ILE2517
BLEU2203-TYR2223
BSER2236-THR2256
BILE2265-LEU2285

site_idSWS_FT_FI3
Number of Residues624
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
APRO2224-ASP2235
DPRO2224-ASP2235
DGLY2286-GLY2325
DPHE2390-TYR2496
AGLY2286-GLY2325
APHE2390-TYR2496
BPRO2224-ASP2235
BGLY2286-GLY2325
BPHE2390-TYR2496
CPRO2224-ASP2235
CGLY2286-GLY2325
CPHE2390-TYR2496

site_idSWS_FT_FI4
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:6DQZ, ECO:0007744|PDB:7T3P, ECO:0007744|PDB:8TKF
ChainResidueDetails
AARG266
BLEU269
BARG510
BTYR567
BARG568
BLYS569
CARG266
CTHR268
CLEU269
CARG510
CTYR567
ATHR268
CARG568
CLYS569
DARG266
DTHR268
DLEU269
DARG510
DTYR567
DARG568
DLYS569
ALEU269
AARG510
ATYR567
AARG568
ALYS569
BARG266
BTHR268

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:7T3P, ECO:0007744|PDB:8TKF
ChainResidueDetails
AARG270
BARG270
CARG270
DARG270

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000305|PubMed:30013099, ECO:0007744|PDB:6DQZ
ChainResidueDetails
AARG503
BARG503
CARG503
DARG503

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:6DQN, ECO:0007744|PDB:7T3P, ECO:0007744|PDB:8TKF
ChainResidueDetails
ALYS507
BLYS507
CLYS507
DLYS507

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0007744|PDB:6DRA
ChainResidueDetails
AARG743
BARG743
CARG743
DARG743

site_idSWS_FT_FI9
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0007744|PDB:6DR2, ECO:0007744|PDB:6DRA
ChainResidueDetails
AGLU1122
BGLU1122
CGLU1122
DGLU1122

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:6DR2, ECO:0007744|PDB:8TKG
ChainResidueDetails
AGLU1125
BGLU1125
CGLU1125
DGLU1125

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:6DRA, ECO:0007744|PDB:7T3U, ECO:0007744|PDB:8TL9
ChainResidueDetails
AGLU1882
DGLU1882
DGLU1946
DTHR2581
AGLU1946
ATHR2581
BGLU1882
BGLU1946
BTHR2581
CGLU1882
CGLU1946
CTHR2581

site_idSWS_FT_FI12
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:35301323, ECO:0007744|PDB:7T3R
ChainResidueDetails
AALA1996
AGLU2149
BALA1996
BGLU2149
CALA1996
CGLU2149
DALA1996
DGLU2149

site_idSWS_FT_FI13
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:7T3R, ECO:0007744|PDB:8TKG
ChainResidueDetails
ALYS2152
DLYS2152
DPHE2539
DLYS2560
APHE2539
ALYS2560
BLYS2152
BPHE2539
BLYS2560
CLYS2152
CPHE2539
CLYS2560

site_idSWS_FT_FI14
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:6DR0, ECO:0007744|PDB:7T3P, ECO:0007744|PDB:8TKD
ChainResidueDetails
ACYS2538
CCYS2541
CHIS2558
CHIS2563
DCYS2538
DCYS2541
DHIS2558
DHIS2563
ACYS2541
AHIS2558
AHIS2563
BCYS2538
BCYS2541
BHIS2558
BHIS2563
CCYS2538

site_idSWS_FT_FI15
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000312|PDB:8TKG, ECO:0007744|PDB:7T3R
ChainResidueDetails
AASN2564
BASN2564
CASN2564
DASN2564

site_idSWS_FT_FI16
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0007744|PDB:7T3R, ECO:0007744|PDB:8TKI
ChainResidueDetails
AMET2565
BMET2565
CMET2565
DMET2565

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER916
BSER916
CSER916
DSER916

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER934
BSER934
CSER934
DSER934

site_idSWS_FT_FI19
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER1813
BSER1813
CSER1813
DSER1813

site_idSWS_FT_FI20
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1832
BSER1832
CSER1832
DSER1832

site_idSWS_FT_FI21
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1834
ASER2609
BSER1834
BSER2609
CSER1834
CSER2609
DSER1834
DSER2609

site_idSWS_FT_FI22
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2670
BSER2670
CSER2670
DSER2670

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon