8TJ3
Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0008955 | molecular_function | peptidoglycan glycosyltransferase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0015648 | molecular_function | lipid-linked peptidoglycan transporter activity |
| B | 0015836 | biological_process | lipid-linked peptidoglycan transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0031504 | biological_process | peptidoglycan-based cell wall organization |
| B | 0032153 | cellular_component | cell division site |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
| C | 0004180 | molecular_function | carboxypeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008360 | biological_process | regulation of cell shape |
| C | 0008658 | molecular_function | penicillin binding |
| C | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
| C | 0009252 | biological_process | peptidoglycan biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0071555 | biological_process | cell wall organization |
| C | 0071972 | molecular_function | peptidoglycan L,D-transpeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00428 |
| Number of Residues | 25 |
| Details | FTSW_RODA_SPOVE Cell cycle proteins ftsW / rodA / spoVE signature. NigmvsGIlPVvGVplpLVSYGGSA |
| Chain | Residue | Details |
| B | ASN321-ALA345 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:37620344 |
| Chain | Residue | Details |
| C | MET378-ALA398 | |
| B | TYR71-TRP74 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_02081 |
| Chain | Residue | Details |
| C | LEU399-LEU419 | |
| B | ILE50-VAL70 | |
| B | ALA75-ILE95 | |
| B | SER136-ALA156 | |
| B | LEU160-SER180 | |
| B | LEU183-MET203 | |
| B | PHE263-LEU283 | |
| B | LEU312-VAL332 | |
| B | LEU336-VAL356 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 590 |
| Details | TOPO_DOM: Periplasmic => ECO:0000305|PubMed:37620344 |
| Chain | Residue | Details |
| C | GLN420-HIS1010 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000255|HAMAP-Rule:MF_02081, ECO:0000269|PubMed:30995398, ECO:0000269|PubMed:3148617, ECO:0000269|PubMed:37620344 |
| Chain | Residue | Details |
| C | SER707 | |
| B | GLN157-ASP159 | |
| B | HIS204-ASP262 | |
| B | GLY333-PRO335 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:37620344 |
| Chain | Residue | Details |
| B | PRO112-ARG130 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:37620344 |
| Chain | Residue | Details |
| B | ASP131-PRO135 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 41 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | TRP181-ARG182 | |
| B | TYR284-MET311 | |
| B | MET357-VAL370 |
