8THO
Solution structure of the zinc finger repeat domain of BCL11A (ZnF456)
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cey..CgkvFkncsnltvHrrs..H |
| Chain | Residue | Details |
| A | CYS9-HIS29 | |
| A | CYS37-HIS57 | |
| A | CYS67-HIS88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 5","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | Zinc finger: {"description":"C2H2-type 6","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 98 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
