8TE3
Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer
Functional Information from PROSITE/UniProt
site_id | PS00094 |
Number of Residues | 13 |
Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS |
Chain | Residue | Details |
A | ASP702-SER714 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018 |
Chain | Residue | Details |
A | CYS710 | |
B | CYS710 | |
C | CYS710 | |
E | CYS710 | |
H | CYS710 | |
F | CYS710 | |
D | CYS710 | |
G | CYS710 |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17713477, ECO:0007744|PDB:2QRV |
Chain | Residue | Details |
A | ASP641 | |
C | GLU664 | |
C | ASP686 | |
C | ARG891 | |
E | ASP641 | |
E | GLU664 | |
E | ASP686 | |
E | ARG891 | |
H | ASP641 | |
H | GLU664 | |
H | ASP686 | |
A | GLU664 | |
H | ARG891 | |
F | ASP641 | |
F | GLU664 | |
F | ASP686 | |
F | ARG891 | |
D | ASP641 | |
D | GLU664 | |
D | ASP686 | |
D | ARG891 | |
G | ASP641 | |
A | ASP686 | |
G | GLU664 | |
G | ASP686 | |
G | ARG891 | |
A | ARG891 | |
B | ASP641 | |
B | GLU664 | |
B | ASP686 | |
B | ARG891 | |
C | ASP641 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | MOD_RES: S-methylcysteine; by autocatalysis => ECO:0000250|UniProtKB:O88508 |
Chain | Residue | Details |
A | CYS710 | |
B | CYS710 | |
C | CYS710 | |
E | CYS710 | |
H | CYS710 | |
F | CYS710 | |
D | CYS710 | |
G | CYS710 |