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8TA4

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal

Functional Information from GO Data
ChainGOidnamespacecontents
A0005247molecular_functionvoltage-gated chloride channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006821biological_processchloride transport
A0006911biological_processphagocytosis, engulfment
A0008308molecular_functionvoltage-gated monoatomic anion channel activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0017081molecular_functionchloride channel regulator activity
A0030322biological_processstabilization of membrane potential
A0030324biological_processlung development
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032347biological_processregulation of aldosterone biosynthetic process
A0032591cellular_componentdendritic spine membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042995cellular_componentcell projection
A0043194cellular_componentaxon initial segment
A0043204cellular_componentperikaryon
A0043209cellular_componentmyelin sheath
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0055085biological_processtransmembrane transport
A0060041biological_processretina development in camera-type eye
A0060075biological_processregulation of resting membrane potential
A0060689biological_processcell differentiation involved in salivary gland development
A0071476biological_processcellular hypotonic response
A0072320molecular_functionvolume-sensitive chloride channel activity
A0090425biological_processacinar cell differentiation
A0097450cellular_componentastrocyte end-foot
A0098656biological_processmonoatomic anion transmembrane transport
A0098902biological_processregulation of membrane depolarization during action potential
A1902476biological_processchloride transmembrane transport
B0005247molecular_functionvoltage-gated chloride channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006821biological_processchloride transport
B0006911biological_processphagocytosis, engulfment
B0008308molecular_functionvoltage-gated monoatomic anion channel activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0017081molecular_functionchloride channel regulator activity
B0030322biological_processstabilization of membrane potential
B0030324biological_processlung development
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032347biological_processregulation of aldosterone biosynthetic process
B0032591cellular_componentdendritic spine membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0042995cellular_componentcell projection
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0043209cellular_componentmyelin sheath
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0055085biological_processtransmembrane transport
B0060041biological_processretina development in camera-type eye
B0060075biological_processregulation of resting membrane potential
B0060689biological_processcell differentiation involved in salivary gland development
B0071476biological_processcellular hypotonic response
B0072320molecular_functionvolume-sensitive chloride channel activity
B0090425biological_processacinar cell differentiation
B0097450cellular_componentastrocyte end-foot
B0098656biological_processmonoatomic anion transmembrane transport
B0098902biological_processregulation of membrane depolarization during action potential
B1902476biological_processchloride transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues868
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AALA2-VAL87
AGLN549-GLN898
BALA2-VAL87
BGLN549-GLN898

site_idSWS_FT_FI2
Number of Residues442
DetailsTRANSMEM: Helical => ECO:0000250
ChainResidueDetails
AGLY88-TRP121
AILE531-LEU548
BGLY88-TRP121
BILE130-LEU155
BLEU180-SER198
BGLU205-LEU223
BTYR275-TRP295
BLEU321-MET349
BPHE358-LEU377
BALA429-ALA449
BGLY457-TRP480
AILE130-LEU155
BILE531-LEU548
ALEU180-SER198
AGLU205-LEU223
ATYR275-TRP295
ALEU321-MET349
APHE358-LEU377
AALA429-ALA449
AGLY457-TRP480

site_idSWS_FT_FI3
Number of Residues14
DetailsINTRAMEM: Helical => ECO:0000255
ChainResidueDetails
AILE164-LEU171
BILE164-LEU171

site_idSWS_FT_FI4
Number of Residues90
DetailsINTRAMEM: Helical => ECO:0000250
ChainResidueDetails
AMET239-CYS251
APRO255-ILE263
AGLY497-VAL511
ATHR514-THR525
BMET239-CYS251
BPRO255-ILE263
BGLY497-VAL511
BTHR514-THR525

site_idSWS_FT_FI5
Number of Residues10
DetailsINTRAMEM: Note=Loop between two helices => ECO:0000250
ChainResidueDetails
ATHR512-HIS513
AGLY526-HIS530
BTHR512-HIS513
BGLY526-HIS530

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER162
APHE459
ATYR553
BSER162
BPHE459
BTYR553

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Protopore gate => ECO:0000269|PubMed:38345841
ChainResidueDetails
AGLU205
BGLU205

site_idSWS_FT_FI8
Number of Residues2
DetailsSITE: Couples extracellular acidification to the channel closure => ECO:0000250|UniProtKB:Q9WU45
ChainResidueDetails
AHIS530
BHIS530

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9R0A1
ChainResidueDetails
ATHR20
BTHR20

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER712
BSER712

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P35525
ChainResidueDetails
ASER758
BSER758

226707

PDB entries from 2024-10-30

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