8T9D

CryoEM structure of TR-TRAP

Functional Information from GO Data

Chain	GOid	namespace	contents
9	0000122	biological_process	negative regulation of transcription by RNA polymerase II
9	0003712	molecular_function	transcription coregulator activity
9	0003713	molecular_function	transcription coactivator activity
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0006357	biological_process	regulation of transcription by RNA polymerase II
9	0016020	cellular_component	membrane
9	0016592	cellular_component	mediator complex
9	0042632	biological_process	cholesterol homeostasis
9	0042809	molecular_function	nuclear vitamin D receptor binding
9	0045893	biological_process	positive regulation of DNA-templated transcription
9	0045944	biological_process	positive regulation of transcription by RNA polymerase II
9	0046966	molecular_function	nuclear thyroid hormone receptor binding
9	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
9	0070328	biological_process	triglyceride homeostasis
9	1990508	cellular_component	CKM complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000151	cellular_component	ubiquitin ligase complex
A	0000785	cellular_component	chromatin
A	0000902	biological_process	cell morphogenesis
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001223	molecular_function	transcription coactivator binding
A	0001525	biological_process	angiogenesis
A	0001701	biological_process	in utero embryonic development
A	0001889	biological_process	liver development
A	0001892	biological_process	embryonic placenta development
A	0002088	biological_process	lens development in camera-type eye
A	0002154	biological_process	thyroid hormone receptor signaling pathway
A	0003222	biological_process	ventricular trabecula myocardium morphogenesis
A	0003406	biological_process	retinal pigment epithelium development
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006590	biological_process	thyroid hormone generation
A	0006606	biological_process	protein import into nucleus
A	0006702	biological_process	androgen biosynthetic process
A	0007420	biological_process	brain development
A	0007507	biological_process	heart development
A	0007595	biological_process	lactation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009887	biological_process	animal organ morphogenesis
A	0010628	biological_process	positive regulation of gene expression
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016592	cellular_component	mediator complex
A	0016922	molecular_function	nuclear receptor binding
A	0030216	biological_process	keratinocyte differentiation
A	0030224	biological_process	monocyte differentiation
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
A	0031100	biological_process	animal organ regeneration
A	0031490	molecular_function	chromatin DNA binding
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0032993	cellular_component	protein-DNA complex
A	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
A	0033598	biological_process	mammary gland epithelial cell proliferation
A	0035035	molecular_function	histone acetyltransferase binding
A	0035050	biological_process	embryonic heart tube development
A	0035116	biological_process	embryonic hindlimb morphogenesis
A	0035162	biological_process	embryonic hemopoiesis
A	0035357	biological_process	peroxisome proliferator activated receptor signaling pathway
A	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
A	0035855	biological_process	megakaryocyte development
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0042809	molecular_function	nuclear vitamin D receptor binding
A	0042974	molecular_function	nuclear retinoic acid receptor binding
A	0042975	molecular_function	peroxisome proliferator activated receptor binding
A	0043010	biological_process	camera-type eye development
A	0043066	biological_process	negative regulation of apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045023	biological_process	G0 to G1 transition
A	0045444	biological_process	fat cell differentiation
A	0045618	biological_process	positive regulation of keratinocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046966	molecular_function	nuclear thyroid hormone receptor binding
A	0048821	biological_process	erythrocyte development
A	0048822	biological_process	enucleate erythrocyte development
A	0050693	molecular_function	LBD domain binding
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060218	biological_process	hematopoietic stem cell differentiation
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0060335	biological_process	positive regulation of type II interferon-mediated signaling pathway
A	0060744	biological_process	mammary gland branching involved in thelarche
A	0060745	biological_process	mammary gland branching involved in pregnancy
A	0060750	biological_process	epithelial cell proliferation involved in mammary gland duct elongation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070318	biological_process	positive regulation of G0 to G1 transition
A	0070562	biological_process	regulation of vitamin D receptor signaling pathway
A	0070847	cellular_component	core mediator complex
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0071383	biological_process	cellular response to steroid hormone stimulus
A	0097067	biological_process	cellular response to thyroid hormone stimulus
A	0140296	molecular_function	general transcription initiation factor binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1990841	molecular_function	promoter-specific chromatin binding
A	2000347	biological_process	positive regulation of hepatocyte proliferation
A	2001141	biological_process	regulation of RNA biosynthetic process
B	0003712	molecular_function	transcription coregulator activity
B	0003713	molecular_function	transcription coactivator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006366	biological_process	transcription by RNA polymerase II
B	0016020	cellular_component	membrane
B	0016592	cellular_component	mediator complex
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0042809	molecular_function	nuclear vitamin D receptor binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046966	molecular_function	nuclear thyroid hormone receptor binding
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	0070847	cellular_component	core mediator complex
C	0000151	cellular_component	ubiquitin ligase complex
C	0001223	molecular_function	transcription coactivator binding
C	0003677	molecular_function	DNA binding
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016020	cellular_component	membrane
C	0016567	biological_process	protein ubiquitination
C	0016592	cellular_component	mediator complex
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0035019	biological_process	somatic stem cell population maintenance
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070847	cellular_component	core mediator complex
D	0000151	cellular_component	ubiquitin ligase complex
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005667	cellular_component	transcription regulator complex
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016567	biological_process	protein ubiquitination
D	0016592	cellular_component	mediator complex
D	0016604	cellular_component	nuclear body
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0035019	biological_process	somatic stem cell population maintenance
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070847	cellular_component	core mediator complex
E	0000151	cellular_component	ubiquitin ligase complex
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0003712	molecular_function	transcription coregulator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016567	biological_process	protein ubiquitination
E	0016592	cellular_component	mediator complex
E	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0070847	cellular_component	core mediator complex
F	0003712	molecular_function	transcription coregulator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0070847	cellular_component	core mediator complex
G	0000151	cellular_component	ubiquitin ligase complex
G	0003712	molecular_function	transcription coregulator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016567	biological_process	protein ubiquitination
G	0016592	cellular_component	mediator complex
G	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
G	0035019	biological_process	somatic stem cell population maintenance
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0070847	cellular_component	core mediator complex
H	0000151	cellular_component	ubiquitin ligase complex
H	0003712	molecular_function	transcription coregulator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070847	cellular_component	core mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0003713	molecular_function	transcription coactivator activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016020	cellular_component	membrane
I	0016592	cellular_component	mediator complex
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0035019	biological_process	somatic stem cell population maintenance
I	0042809	molecular_function	nuclear vitamin D receptor binding
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0070847	cellular_component	core mediator complex
J	0003712	molecular_function	transcription coregulator activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006355	biological_process	regulation of DNA-templated transcription
J	0016020	cellular_component	membrane
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0035019	biological_process	somatic stem cell population maintenance
J	0051123	biological_process	RNA polymerase II preinitiation complex assembly
J	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
J	0070847	cellular_component	core mediator complex
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006366	biological_process	transcription by RNA polymerase II
K	0016020	cellular_component	membrane
K	0016592	cellular_component	mediator complex
K	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
K	0042809	molecular_function	nuclear vitamin D receptor binding
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046966	molecular_function	nuclear thyroid hormone receptor binding
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0070847	cellular_component	core mediator complex
L	0000151	cellular_component	ubiquitin ligase complex
L	0003712	molecular_function	transcription coregulator activity
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005667	cellular_component	transcription regulator complex
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0016020	cellular_component	membrane
L	0016567	biological_process	protein ubiquitination
L	0016592	cellular_component	mediator complex
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0035019	biological_process	somatic stem cell population maintenance
L	0042809	molecular_function	nuclear vitamin D receptor binding
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046966	molecular_function	nuclear thyroid hormone receptor binding
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0070847	cellular_component	core mediator complex
M	0003712	molecular_function	transcription coregulator activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0016592	cellular_component	mediator complex
M	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0070847	cellular_component	core mediator complex
O	0003712	molecular_function	transcription coregulator activity
O	0003713	molecular_function	transcription coactivator activity
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0006351	biological_process	DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006366	biological_process	transcription by RNA polymerase II
O	0016592	cellular_component	mediator complex
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0032991	cellular_component	protein-containing complex
O	0035914	biological_process	skeletal muscle cell differentiation
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0070847	cellular_component	core mediator complex
P	0000151	cellular_component	ubiquitin ligase complex
P	0001824	biological_process	blastocyst development
P	0003712	molecular_function	transcription coregulator activity
P	0003713	molecular_function	transcription coactivator activity
P	0003899	molecular_function	DNA-directed RNA polymerase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0016567	biological_process	protein ubiquitination
P	0016592	cellular_component	mediator complex
P	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
P	0035019	biological_process	somatic stem cell population maintenance
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0061630	molecular_function	ubiquitin protein ligase activity
P	0070847	cellular_component	core mediator complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0016592	cellular_component	mediator complex
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Q	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Q	0070847	cellular_component	core mediator complex
R	0003713	molecular_function	transcription coactivator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005667	cellular_component	transcription regulator complex
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0010628	biological_process	positive regulation of gene expression
R	0016592	cellular_component	mediator complex
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
R	2000409	biological_process	positive regulation of T cell extravasation
S	0003712	molecular_function	transcription coregulator activity
S	0003713	molecular_function	transcription coactivator activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006366	biological_process	transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0035019	biological_process	somatic stem cell population maintenance
S	0042809	molecular_function	nuclear vitamin D receptor binding
S	0045893	biological_process	positive regulation of DNA-templated transcription
S	0046966	molecular_function	nuclear thyroid hormone receptor binding
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0070847	cellular_component	core mediator complex
T	0000122	biological_process	negative regulation of transcription by RNA polymerase II
T	0001223	molecular_function	transcription coactivator binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005667	cellular_component	transcription regulator complex
T	0016592	cellular_component	mediator complex
T	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
T	0035563	biological_process	positive regulation of chromatin binding
T	0042974	molecular_function	nuclear retinoic acid receptor binding
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0046965	molecular_function	nuclear retinoid X receptor binding
T	0048147	biological_process	negative regulation of fibroblast proliferation
T	0051123	biological_process	RNA polymerase II preinitiation complex assembly
T	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
T	0070847	cellular_component	core mediator complex
T	2001178	biological_process	positive regulation of mediator complex assembly
V	0000151	cellular_component	ubiquitin ligase complex
V	0003713	molecular_function	transcription coactivator activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005667	cellular_component	transcription regulator complex
V	0005730	cellular_component	nucleolus
V	0005829	cellular_component	cytosol
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0016567	biological_process	protein ubiquitination
V	0016592	cellular_component	mediator complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0035019	biological_process	somatic stem cell population maintenance
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0061630	molecular_function	ubiquitin protein ligase activity
V	0070847	cellular_component	core mediator complex
W	0003779	molecular_function	actin binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0016020	cellular_component	membrane
W	0016592	cellular_component	mediator complex
W	0030864	cellular_component	cortical actin cytoskeleton
W	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
W	0035019	biological_process	somatic stem cell population maintenance
W	0051123	biological_process	RNA polymerase II preinitiation complex assembly
W	0051151	biological_process	negative regulation of smooth muscle cell differentiation
W	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
W	0070847	cellular_component	core mediator complex
X	0003712	molecular_function	transcription coregulator activity
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0016592	cellular_component	mediator complex
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0051123	biological_process	RNA polymerase II preinitiation complex assembly
X	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
X	0070847	cellular_component	core mediator complex
Y	0000151	cellular_component	ubiquitin ligase complex
Y	0003712	molecular_function	transcription coregulator activity
Y	0003713	molecular_function	transcription coactivator activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0016567	biological_process	protein ubiquitination
Y	0016592	cellular_component	mediator complex
Y	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Y	0035019	biological_process	somatic stem cell population maintenance
Y	0042809	molecular_function	nuclear vitamin D receptor binding
Y	0045893	biological_process	positive regulation of DNA-templated transcription
Y	0046966	molecular_function	nuclear thyroid hormone receptor binding
Y	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Y	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Y	0061630	molecular_function	ubiquitin protein ligase activity
Y	0070847	cellular_component	core mediator complex
Z	0000151	cellular_component	ubiquitin ligase complex
Z	0003712	molecular_function	transcription coregulator activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0016567	biological_process	protein ubiquitination
Z	0016592	cellular_component	mediator complex
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0048147	biological_process	negative regulation of fibroblast proliferation
Z	0051123	biological_process	RNA polymerase II preinitiation complex assembly
Z	0060173	biological_process	limb development
Z	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
Z	0061630	molecular_function	ubiquitin protein ligase activity
Z	0070847	cellular_component	core mediator complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. SSGMKSSSGLGSSGSL

Chain	Residue	Details
A	SER1240-LEU1255

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site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. MKsSsGLGSSGS

Chain	Residue	Details
A	MET1243-SER1254

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER617
C	LYS241
9	SER890

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
I	SER986

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER1112

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER1119

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER1128
I	SER1136

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
I	SER1144
A	SER1465

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by MAPK1 or MAPK3 => ECO:0000269|PubMed:16314496

Chain	Residue	Details
A	THR1032
A	THR1457

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1051

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1057

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1156
A	SER1223

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1177
A	LYS1529

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1207

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1215

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER1347
A	SER1403

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1433

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1440

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1463
A	SER1481
A	SER1482

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1479

---