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8T7T

CryoEM structure of the HisRS-like domain of human GCN2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0000077biological_processDNA damage checkpoint signaling
A0000166molecular_functionnucleotide binding
A0002230biological_processpositive regulation of defense response to virus by host
A0002250biological_processadaptive immune response
A0002286biological_processT cell activation involved in immune response
A0002376biological_processimmune system process
A0002821biological_processpositive regulation of adaptive immune response
A0003723molecular_functionRNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006417biological_processregulation of translation
A0006446biological_processregulation of translational initiation
A0006468biological_processprotein phosphorylation
A0007399biological_processnervous system development
A0007612biological_processlearning
A0007616biological_processlong-term memory
A0010998biological_processregulation of translational initiation by eIF2 alpha phosphorylation
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019081biological_processviral translation
A0022626cellular_componentcytosolic ribosome
A0032057biological_processnegative regulation of translational initiation in response to stress
A0032792biological_processobsolete negative regulation of CREB transcription factor activity
A0034198biological_processcellular response to amino acid starvation
A0034644biological_processcellular response to UV
A0044828biological_processhost-mediated suppression of viral genome replication
A0045665biological_processnegative regulation of neuron differentiation
A0045947biological_processnegative regulation of translational initiation
A0046777biological_processprotein autophosphorylation
A0051607biological_processdefense response to virus
A0051726biological_processregulation of cell cycle
A0060259biological_processregulation of feeding behavior
A0070417biological_processcellular response to cold
A0071264biological_processpositive regulation of translational initiation in response to starvation
A0106310molecular_functionprotein serine kinase activity
A0140469biological_processGCN2-mediated signaling
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1990138biological_processneuron projection extension
A1990928biological_processresponse to amino acid starvation
B0000049molecular_functiontRNA binding
B0000077biological_processDNA damage checkpoint signaling
B0000166molecular_functionnucleotide binding
B0002230biological_processpositive regulation of defense response to virus by host
B0002250biological_processadaptive immune response
B0002286biological_processT cell activation involved in immune response
B0002376biological_processimmune system process
B0002821biological_processpositive regulation of adaptive immune response
B0003723molecular_functionRNA binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006417biological_processregulation of translation
B0006446biological_processregulation of translational initiation
B0006468biological_processprotein phosphorylation
B0007399biological_processnervous system development
B0007612biological_processlearning
B0007616biological_processlong-term memory
B0010998biological_processregulation of translational initiation by eIF2 alpha phosphorylation
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019081biological_processviral translation
B0022626cellular_componentcytosolic ribosome
B0032057biological_processnegative regulation of translational initiation in response to stress
B0032792biological_processobsolete negative regulation of CREB transcription factor activity
B0034198biological_processcellular response to amino acid starvation
B0034644biological_processcellular response to UV
B0044828biological_processhost-mediated suppression of viral genome replication
B0045665biological_processnegative regulation of neuron differentiation
B0045947biological_processnegative regulation of translational initiation
B0046777biological_processprotein autophosphorylation
B0051607biological_processdefense response to virus
B0051726biological_processregulation of cell cycle
B0060259biological_processregulation of feeding behavior
B0070417biological_processcellular response to cold
B0071264biological_processpositive regulation of translational initiation in response to starvation
B0106310molecular_functionprotein serine kinase activity
B0140469biological_processGCN2-mediated signaling
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1990138biological_processneuron projection extension
B1990928biological_processresponse to amino acid starvation
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFGAVIkVqnkldgcc..........YAVK
ChainResidueDetails
ALEU596-LYS619

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. MiHrDLKpvNIFL
ChainResidueDetails
AMET844-LEU856

site_idPS00116
Number of Residues9
DetailsDNA_POLYMERASE_B DNA polymerase family B signature. ASDTDGLDS
ChainResidueDetails
AALA687-SER695

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues942
DetailsRegion: {"description":"Histidyl-tRNA synthetase-like"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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