Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8T71

Crystal Structure of WT KRAS4a with bound GDP and Mg ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001889	biological_process	liver development
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0007565	biological_process	female pregnancy
A	0008283	biological_process	cell population proliferation
A	0008542	biological_process	visual learning
A	0009629	biological_process	response to gravity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010467	biological_process	gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0012505	cellular_component	endomembrane system
A	0014009	biological_process	glial cell proliferation
A	0016020	cellular_component	membrane
A	0016601	biological_process	Rac protein signal transduction
A	0016787	molecular_function	hydrolase activity
A	0019002	molecular_function	GMP binding
A	0019003	molecular_function	GDP binding
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0021897	biological_process	forebrain astrocyte development
A	0030036	biological_process	actin cytoskeleton organization
A	0030275	molecular_function	LRR domain binding
A	0030857	biological_process	negative regulation of epithelial cell differentiation
A	0032228	biological_process	regulation of synaptic transmission, GABAergic
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0035900	biological_process	response to isolation stress
A	0035914	biological_process	skeletal muscle cell differentiation
A	0043495	molecular_function	membrane-membrane adaptor activity
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0051146	biological_process	striated muscle cell differentiation
A	0051384	biological_process	response to glucocorticoid
A	0051385	biological_process	response to mineralocorticoid
A	0051402	biological_process	neuron apoptotic process
A	0051450	biological_process	myoblast proliferation
A	0060038	biological_process	cardiac muscle cell proliferation
A	0060252	biological_process	positive regulation of glial cell proliferation
A	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
A	0060509	biological_process	type I pneumocyte differentiation
A	2000774	biological_process	positive regulation of cellular senescence
B	0000139	cellular_component	Golgi membrane
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0001889	biological_process	liver development
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0007165	biological_process	signal transduction
B	0007265	biological_process	Ras protein signal transduction
B	0007565	biological_process	female pregnancy
B	0008283	biological_process	cell population proliferation
B	0008542	biological_process	visual learning
B	0009629	biological_process	response to gravity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010467	biological_process	gene expression
B	0010628	biological_process	positive regulation of gene expression
B	0012505	cellular_component	endomembrane system
B	0014009	biological_process	glial cell proliferation
B	0016020	cellular_component	membrane
B	0016601	biological_process	Rac protein signal transduction
B	0016787	molecular_function	hydrolase activity
B	0019002	molecular_function	GMP binding
B	0019003	molecular_function	GDP binding
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0021897	biological_process	forebrain astrocyte development
B	0030036	biological_process	actin cytoskeleton organization
B	0030275	molecular_function	LRR domain binding
B	0030857	biological_process	negative regulation of epithelial cell differentiation
B	0032228	biological_process	regulation of synaptic transmission, GABAergic
B	0035022	biological_process	positive regulation of Rac protein signal transduction
B	0035900	biological_process	response to isolation stress
B	0035914	biological_process	skeletal muscle cell differentiation
B	0043495	molecular_function	membrane-membrane adaptor activity
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0044877	molecular_function	protein-containing complex binding
B	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
B	0048873	biological_process	homeostasis of number of cells within a tissue
B	0051146	biological_process	striated muscle cell differentiation
B	0051384	biological_process	response to glucocorticoid
B	0051385	biological_process	response to mineralocorticoid
B	0051402	biological_process	neuron apoptotic process
B	0051450	biological_process	myoblast proliferation
B	0060038	biological_process	cardiac muscle cell proliferation
B	0060252	biological_process	positive regulation of glial cell proliferation
B	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
B	0060509	biological_process	type I pneumocyte differentiation
B	2000774	biological_process	positive regulation of cellular senescence

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)