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8T6Q

Cryo-EM structure of dodecameric CaMKII beta holoenzyme T287A T306A T307A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0003674molecular_functionmolecular_function
A0004674molecular_functionprotein serine/threonine kinase activity
A0004683molecular_functioncalmodulin-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005575cellular_componentcellular_component
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
A0006091biological_processgeneration of precursor metabolites and energy
A0006816biological_processcalcium ion transport
A0007399biological_processnervous system development
A0008218biological_processbioluminescence
A0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
A0010976biological_processpositive regulation of neuron projection development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016310biological_processphosphorylation
A0016529cellular_componentsarcoplasmic reticulum
A0019901molecular_functionprotein kinase binding
A0030154biological_processcell differentiation
A0030425cellular_componentdendrite
A0032222biological_processregulation of synaptic transmission, cholinergic
A0033017cellular_componentsarcoplasmic reticulum membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043204cellular_componentperikaryon
A0043274molecular_functionphospholipase binding
A0045202cellular_componentsynapse
A0046686biological_processresponse to cadmium ion
A0046777biological_processprotein autophosphorylation
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048858biological_processcell projection morphogenesis
A0050885biological_processneuromuscular process controlling balance
A0051233cellular_componentspindle midzone
A0060291biological_processlong-term synaptic potentiation
A0060466biological_processactivation of meiosis involved in egg activation
A0061003biological_processpositive regulation of dendritic spine morphogenesis
A0090128biological_processregulation of synapse maturation
A0090129biological_processpositive regulation of synapse maturation
A0097190biological_processapoptotic signaling pathway
A0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A0106310molecular_functionprotein serine kinase activity
A0110088biological_processhippocampal neuron apoptotic process
A1903076biological_processregulation of protein localization to plasma membrane
A1905375biological_processcellular response to homocysteine
A1990911biological_processresponse to psychosocial stress
A2001222biological_processregulation of neuron migration
A2001235biological_processpositive regulation of apoptotic signaling pathway
B0000082biological_processG1/S transition of mitotic cell cycle
B0003674molecular_functionmolecular_function
B0004674molecular_functionprotein serine/threonine kinase activity
B0004683molecular_functioncalmodulin-dependent protein kinase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005575cellular_componentcellular_component
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
B0006091biological_processgeneration of precursor metabolites and energy
B0006816biological_processcalcium ion transport
B0007399biological_processnervous system development
B0008218biological_processbioluminescence
B0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
B0010976biological_processpositive regulation of neuron projection development
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016310biological_processphosphorylation
B0016529cellular_componentsarcoplasmic reticulum
B0019901molecular_functionprotein kinase binding
B0030154biological_processcell differentiation
B0030425cellular_componentdendrite
B0032222biological_processregulation of synaptic transmission, cholinergic
B0033017cellular_componentsarcoplasmic reticulum membrane
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043204cellular_componentperikaryon
B0043274molecular_functionphospholipase binding
B0045202cellular_componentsynapse
B0046686biological_processresponse to cadmium ion
B0046777biological_processprotein autophosphorylation
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048858biological_processcell projection morphogenesis
B0050885biological_processneuromuscular process controlling balance
B0051233cellular_componentspindle midzone
B0060291biological_processlong-term synaptic potentiation
B0060466biological_processactivation of meiosis involved in egg activation
B0061003biological_processpositive regulation of dendritic spine morphogenesis
B0090128biological_processregulation of synapse maturation
B0090129biological_processpositive regulation of synapse maturation
B0097190biological_processapoptotic signaling pathway
B0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B0106310molecular_functionprotein serine kinase activity
B0110088biological_processhippocampal neuron apoptotic process
B1903076biological_processregulation of protein localization to plasma membrane
B1905375biological_processcellular response to homocysteine
B1990911biological_processresponse to psychosocial stress
B2001222biological_processregulation of neuron migration
B2001235biological_processpositive regulation of apoptotic signaling pathway
C0000082biological_processG1/S transition of mitotic cell cycle
C0003674molecular_functionmolecular_function
C0004674molecular_functionprotein serine/threonine kinase activity
C0004683molecular_functioncalmodulin-dependent protein kinase activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005575cellular_componentcellular_component
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
C0006091biological_processgeneration of precursor metabolites and energy
C0006816biological_processcalcium ion transport
C0007399biological_processnervous system development
C0008218biological_processbioluminescence
C0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
C0010976biological_processpositive regulation of neuron projection development
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0016310biological_processphosphorylation
C0016529cellular_componentsarcoplasmic reticulum
C0019901molecular_functionprotein kinase binding
C0030154biological_processcell differentiation
C0030425cellular_componentdendrite
C0032222biological_processregulation of synaptic transmission, cholinergic
C0033017cellular_componentsarcoplasmic reticulum membrane
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043005cellular_componentneuron projection
C0043204cellular_componentperikaryon
C0043274molecular_functionphospholipase binding
C0045202cellular_componentsynapse
C0046686biological_processresponse to cadmium ion
C0046777biological_processprotein autophosphorylation
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048858biological_processcell projection morphogenesis
C0050885biological_processneuromuscular process controlling balance
C0051233cellular_componentspindle midzone
C0060291biological_processlong-term synaptic potentiation
C0060466biological_processactivation of meiosis involved in egg activation
C0061003biological_processpositive regulation of dendritic spine morphogenesis
C0090128biological_processregulation of synapse maturation
C0090129biological_processpositive regulation of synapse maturation
C0097190biological_processapoptotic signaling pathway
C0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0098978cellular_componentglutamatergic synapse
C0106310molecular_functionprotein serine kinase activity
C0110088biological_processhippocampal neuron apoptotic process
C1903076biological_processregulation of protein localization to plasma membrane
C1905375biological_processcellular response to homocysteine
C1990911biological_processresponse to psychosocial stress
C2001222biological_processregulation of neuron migration
C2001235biological_processpositive regulation of apoptotic signaling pathway
D0000082biological_processG1/S transition of mitotic cell cycle
D0003674molecular_functionmolecular_function
D0004674molecular_functionprotein serine/threonine kinase activity
D0004683molecular_functioncalmodulin-dependent protein kinase activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005575cellular_componentcellular_component
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
D0006091biological_processgeneration of precursor metabolites and energy
D0006816biological_processcalcium ion transport
D0007399biological_processnervous system development
D0008218biological_processbioluminescence
D0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
D0010976biological_processpositive regulation of neuron projection development
D0014069cellular_componentpostsynaptic density
D0016020cellular_componentmembrane
D0016310biological_processphosphorylation
D0016529cellular_componentsarcoplasmic reticulum
D0019901molecular_functionprotein kinase binding
D0030154biological_processcell differentiation
D0030425cellular_componentdendrite
D0032222biological_processregulation of synaptic transmission, cholinergic
D0033017cellular_componentsarcoplasmic reticulum membrane
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043204cellular_componentperikaryon
D0043274molecular_functionphospholipase binding
D0045202cellular_componentsynapse
D0046686biological_processresponse to cadmium ion
D0046777biological_processprotein autophosphorylation
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048858biological_processcell projection morphogenesis
D0050885biological_processneuromuscular process controlling balance
D0051233cellular_componentspindle midzone
D0060291biological_processlong-term synaptic potentiation
D0060466biological_processactivation of meiosis involved in egg activation
D0061003biological_processpositive regulation of dendritic spine morphogenesis
D0090128biological_processregulation of synapse maturation
D0090129biological_processpositive regulation of synapse maturation
D0097190biological_processapoptotic signaling pathway
D0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0098978cellular_componentglutamatergic synapse
D0106310molecular_functionprotein serine kinase activity
D0110088biological_processhippocampal neuron apoptotic process
D1903076biological_processregulation of protein localization to plasma membrane
D1905375biological_processcellular response to homocysteine
D1990911biological_processresponse to psychosocial stress
D2001222biological_processregulation of neuron migration
D2001235biological_processpositive regulation of apoptotic signaling pathway
F0000082biological_processG1/S transition of mitotic cell cycle
F0003674molecular_functionmolecular_function
F0004674molecular_functionprotein serine/threonine kinase activity
F0004683molecular_functioncalmodulin-dependent protein kinase activity
F0005515molecular_functionprotein binding
F0005516molecular_functioncalmodulin binding
F0005524molecular_functionATP binding
F0005575cellular_componentcellular_component
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
F0006091biological_processgeneration of precursor metabolites and energy
F0006816biological_processcalcium ion transport
F0007399biological_processnervous system development
F0008218biological_processbioluminescence
F0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
F0010976biological_processpositive regulation of neuron projection development
F0014069cellular_componentpostsynaptic density
F0016020cellular_componentmembrane
F0016310biological_processphosphorylation
F0016529cellular_componentsarcoplasmic reticulum
F0019901molecular_functionprotein kinase binding
F0030154biological_processcell differentiation
F0030425cellular_componentdendrite
F0032222biological_processregulation of synaptic transmission, cholinergic
F0033017cellular_componentsarcoplasmic reticulum membrane
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043005cellular_componentneuron projection
F0043204cellular_componentperikaryon
F0043274molecular_functionphospholipase binding
F0045202cellular_componentsynapse
F0046686biological_processresponse to cadmium ion
F0046777biological_processprotein autophosphorylation
F0048169biological_processregulation of long-term neuronal synaptic plasticity
F0048858biological_processcell projection morphogenesis
F0050885biological_processneuromuscular process controlling balance
F0051233cellular_componentspindle midzone
F0060291biological_processlong-term synaptic potentiation
F0060466biological_processactivation of meiosis involved in egg activation
F0061003biological_processpositive regulation of dendritic spine morphogenesis
F0090128biological_processregulation of synapse maturation
F0090129biological_processpositive regulation of synapse maturation
F0097190biological_processapoptotic signaling pathway
F0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
F0098974biological_processpostsynaptic actin cytoskeleton organization
F0098978cellular_componentglutamatergic synapse
F0106310molecular_functionprotein serine kinase activity
F0110088biological_processhippocampal neuron apoptotic process
F1903076biological_processregulation of protein localization to plasma membrane
F1905375biological_processcellular response to homocysteine
F1990911biological_processresponse to psychosocial stress
F2001222biological_processregulation of neuron migration
F2001235biological_processpositive regulation of apoptotic signaling pathway
G0000082biological_processG1/S transition of mitotic cell cycle
G0003674molecular_functionmolecular_function
G0004674molecular_functionprotein serine/threonine kinase activity
G0004683molecular_functioncalmodulin-dependent protein kinase activity
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005575cellular_componentcellular_component
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
G0006091biological_processgeneration of precursor metabolites and energy
G0006816biological_processcalcium ion transport
G0007399biological_processnervous system development
G0008218biological_processbioluminescence
G0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
G0010976biological_processpositive regulation of neuron projection development
G0014069cellular_componentpostsynaptic density
G0016020cellular_componentmembrane
G0016310biological_processphosphorylation
G0016529cellular_componentsarcoplasmic reticulum
G0019901molecular_functionprotein kinase binding
G0030154biological_processcell differentiation
G0030425cellular_componentdendrite
G0032222biological_processregulation of synaptic transmission, cholinergic
G0033017cellular_componentsarcoplasmic reticulum membrane
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043005cellular_componentneuron projection
G0043204cellular_componentperikaryon
G0043274molecular_functionphospholipase binding
G0045202cellular_componentsynapse
G0046686biological_processresponse to cadmium ion
G0046777biological_processprotein autophosphorylation
G0048169biological_processregulation of long-term neuronal synaptic plasticity
G0048858biological_processcell projection morphogenesis
G0050885biological_processneuromuscular process controlling balance
G0051233cellular_componentspindle midzone
G0060291biological_processlong-term synaptic potentiation
G0060466biological_processactivation of meiosis involved in egg activation
G0061003biological_processpositive regulation of dendritic spine morphogenesis
G0090128biological_processregulation of synapse maturation
G0090129biological_processpositive regulation of synapse maturation
G0097190biological_processapoptotic signaling pathway
G0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
G0098974biological_processpostsynaptic actin cytoskeleton organization
G0098978cellular_componentglutamatergic synapse
G0106310molecular_functionprotein serine kinase activity
G0110088biological_processhippocampal neuron apoptotic process
G1903076biological_processregulation of protein localization to plasma membrane
G1905375biological_processcellular response to homocysteine
G1990911biological_processresponse to psychosocial stress
G2001222biological_processregulation of neuron migration
G2001235biological_processpositive regulation of apoptotic signaling pathway
H0000082biological_processG1/S transition of mitotic cell cycle
H0003674molecular_functionmolecular_function
H0004674molecular_functionprotein serine/threonine kinase activity
H0004683molecular_functioncalmodulin-dependent protein kinase activity
H0005515molecular_functionprotein binding
H0005516molecular_functioncalmodulin binding
H0005524molecular_functionATP binding
H0005575cellular_componentcellular_component
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
H0006091biological_processgeneration of precursor metabolites and energy
H0006816biological_processcalcium ion transport
H0007399biological_processnervous system development
H0008218biological_processbioluminescence
H0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
H0010976biological_processpositive regulation of neuron projection development
H0014069cellular_componentpostsynaptic density
H0016020cellular_componentmembrane
H0016310biological_processphosphorylation
H0016529cellular_componentsarcoplasmic reticulum
H0019901molecular_functionprotein kinase binding
H0030154biological_processcell differentiation
H0030425cellular_componentdendrite
H0032222biological_processregulation of synaptic transmission, cholinergic
H0033017cellular_componentsarcoplasmic reticulum membrane
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0043005cellular_componentneuron projection
H0043204cellular_componentperikaryon
H0043274molecular_functionphospholipase binding
H0045202cellular_componentsynapse
H0046686biological_processresponse to cadmium ion
H0046777biological_processprotein autophosphorylation
H0048169biological_processregulation of long-term neuronal synaptic plasticity
H0048858biological_processcell projection morphogenesis
H0050885biological_processneuromuscular process controlling balance
H0051233cellular_componentspindle midzone
H0060291biological_processlong-term synaptic potentiation
H0060466biological_processactivation of meiosis involved in egg activation
H0061003biological_processpositive regulation of dendritic spine morphogenesis
H0090128biological_processregulation of synapse maturation
H0090129biological_processpositive regulation of synapse maturation
H0097190biological_processapoptotic signaling pathway
H0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
H0098974biological_processpostsynaptic actin cytoskeleton organization
H0098978cellular_componentglutamatergic synapse
H0106310molecular_functionprotein serine kinase activity
H0110088biological_processhippocampal neuron apoptotic process
H1903076biological_processregulation of protein localization to plasma membrane
H1905375biological_processcellular response to homocysteine
H1990911biological_processresponse to psychosocial stress
H2001222biological_processregulation of neuron migration
H2001235biological_processpositive regulation of apoptotic signaling pathway
I0000082biological_processG1/S transition of mitotic cell cycle
I0003674molecular_functionmolecular_function
I0004674molecular_functionprotein serine/threonine kinase activity
I0004683molecular_functioncalmodulin-dependent protein kinase activity
I0005515molecular_functionprotein binding
I0005516molecular_functioncalmodulin binding
I0005524molecular_functionATP binding
I0005575cellular_componentcellular_component
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
I0006091biological_processgeneration of precursor metabolites and energy
I0006816biological_processcalcium ion transport
I0007399biological_processnervous system development
I0008218biological_processbioluminescence
I0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
I0010976biological_processpositive regulation of neuron projection development
I0014069cellular_componentpostsynaptic density
I0016020cellular_componentmembrane
I0016310biological_processphosphorylation
I0016529cellular_componentsarcoplasmic reticulum
I0019901molecular_functionprotein kinase binding
I0030154biological_processcell differentiation
I0030425cellular_componentdendrite
I0032222biological_processregulation of synaptic transmission, cholinergic
I0033017cellular_componentsarcoplasmic reticulum membrane
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0043005cellular_componentneuron projection
I0043204cellular_componentperikaryon
I0043274molecular_functionphospholipase binding
I0045202cellular_componentsynapse
I0046686biological_processresponse to cadmium ion
I0046777biological_processprotein autophosphorylation
I0048169biological_processregulation of long-term neuronal synaptic plasticity
I0048858biological_processcell projection morphogenesis
I0050885biological_processneuromuscular process controlling balance
I0051233cellular_componentspindle midzone
I0060291biological_processlong-term synaptic potentiation
I0060466biological_processactivation of meiosis involved in egg activation
I0061003biological_processpositive regulation of dendritic spine morphogenesis
I0090128biological_processregulation of synapse maturation
I0090129biological_processpositive regulation of synapse maturation
I0097190biological_processapoptotic signaling pathway
I0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
I0098974biological_processpostsynaptic actin cytoskeleton organization
I0098978cellular_componentglutamatergic synapse
I0106310molecular_functionprotein serine kinase activity
I0110088biological_processhippocampal neuron apoptotic process
I1903076biological_processregulation of protein localization to plasma membrane
I1905375biological_processcellular response to homocysteine
I1990911biological_processresponse to psychosocial stress
I2001222biological_processregulation of neuron migration
I2001235biological_processpositive regulation of apoptotic signaling pathway
J0000082biological_processG1/S transition of mitotic cell cycle
J0003674molecular_functionmolecular_function
J0004674molecular_functionprotein serine/threonine kinase activity
J0004683molecular_functioncalmodulin-dependent protein kinase activity
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005524molecular_functionATP binding
J0005575cellular_componentcellular_component
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
J0006091biological_processgeneration of precursor metabolites and energy
J0006816biological_processcalcium ion transport
J0007399biological_processnervous system development
J0008218biological_processbioluminescence
J0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
J0010976biological_processpositive regulation of neuron projection development
J0014069cellular_componentpostsynaptic density
J0016020cellular_componentmembrane
J0016310biological_processphosphorylation
J0016529cellular_componentsarcoplasmic reticulum
J0019901molecular_functionprotein kinase binding
J0030154biological_processcell differentiation
J0030425cellular_componentdendrite
J0032222biological_processregulation of synaptic transmission, cholinergic
J0033017cellular_componentsarcoplasmic reticulum membrane
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0043005cellular_componentneuron projection
J0043204cellular_componentperikaryon
J0043274molecular_functionphospholipase binding
J0045202cellular_componentsynapse
J0046686biological_processresponse to cadmium ion
J0046777biological_processprotein autophosphorylation
J0048169biological_processregulation of long-term neuronal synaptic plasticity
J0048858biological_processcell projection morphogenesis
J0050885biological_processneuromuscular process controlling balance
J0051233cellular_componentspindle midzone
J0060291biological_processlong-term synaptic potentiation
J0060466biological_processactivation of meiosis involved in egg activation
J0061003biological_processpositive regulation of dendritic spine morphogenesis
J0090128biological_processregulation of synapse maturation
J0090129biological_processpositive regulation of synapse maturation
J0097190biological_processapoptotic signaling pathway
J0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
J0098974biological_processpostsynaptic actin cytoskeleton organization
J0098978cellular_componentglutamatergic synapse
J0106310molecular_functionprotein serine kinase activity
J0110088biological_processhippocampal neuron apoptotic process
J1903076biological_processregulation of protein localization to plasma membrane
J1905375biological_processcellular response to homocysteine
J1990911biological_processresponse to psychosocial stress
J2001222biological_processregulation of neuron migration
J2001235biological_processpositive regulation of apoptotic signaling pathway
K0000082biological_processG1/S transition of mitotic cell cycle
K0003674molecular_functionmolecular_function
K0004674molecular_functionprotein serine/threonine kinase activity
K0004683molecular_functioncalmodulin-dependent protein kinase activity
K0005515molecular_functionprotein binding
K0005516molecular_functioncalmodulin binding
K0005524molecular_functionATP binding
K0005575cellular_componentcellular_component
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
K0006091biological_processgeneration of precursor metabolites and energy
K0006816biological_processcalcium ion transport
K0007399biological_processnervous system development
K0008218biological_processbioluminescence
K0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
K0010976biological_processpositive regulation of neuron projection development
K0014069cellular_componentpostsynaptic density
K0016020cellular_componentmembrane
K0016310biological_processphosphorylation
K0016529cellular_componentsarcoplasmic reticulum
K0019901molecular_functionprotein kinase binding
K0030154biological_processcell differentiation
K0030425cellular_componentdendrite
K0032222biological_processregulation of synaptic transmission, cholinergic
K0033017cellular_componentsarcoplasmic reticulum membrane
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0043005cellular_componentneuron projection
K0043204cellular_componentperikaryon
K0043274molecular_functionphospholipase binding
K0045202cellular_componentsynapse
K0046686biological_processresponse to cadmium ion
K0046777biological_processprotein autophosphorylation
K0048169biological_processregulation of long-term neuronal synaptic plasticity
K0048858biological_processcell projection morphogenesis
K0050885biological_processneuromuscular process controlling balance
K0051233cellular_componentspindle midzone
K0060291biological_processlong-term synaptic potentiation
K0060466biological_processactivation of meiosis involved in egg activation
K0061003biological_processpositive regulation of dendritic spine morphogenesis
K0090128biological_processregulation of synapse maturation
K0090129biological_processpositive regulation of synapse maturation
K0097190biological_processapoptotic signaling pathway
K0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
K0098974biological_processpostsynaptic actin cytoskeleton organization
K0098978cellular_componentglutamatergic synapse
K0106310molecular_functionprotein serine kinase activity
K0110088biological_processhippocampal neuron apoptotic process
K1903076biological_processregulation of protein localization to plasma membrane
K1905375biological_processcellular response to homocysteine
K1990911biological_processresponse to psychosocial stress
K2001222biological_processregulation of neuron migration
K2001235biological_processpositive regulation of apoptotic signaling pathway
L0000082biological_processG1/S transition of mitotic cell cycle
L0003674molecular_functionmolecular_function
L0004674molecular_functionprotein serine/threonine kinase activity
L0004683molecular_functioncalmodulin-dependent protein kinase activity
L0005515molecular_functionprotein binding
L0005516molecular_functioncalmodulin binding
L0005524molecular_functionATP binding
L0005575cellular_componentcellular_component
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
L0006091biological_processgeneration of precursor metabolites and energy
L0006816biological_processcalcium ion transport
L0007399biological_processnervous system development
L0008218biological_processbioluminescence
L0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
L0010976biological_processpositive regulation of neuron projection development
L0014069cellular_componentpostsynaptic density
L0016020cellular_componentmembrane
L0016310biological_processphosphorylation
L0016529cellular_componentsarcoplasmic reticulum
L0019901molecular_functionprotein kinase binding
L0030154biological_processcell differentiation
L0030425cellular_componentdendrite
L0032222biological_processregulation of synaptic transmission, cholinergic
L0033017cellular_componentsarcoplasmic reticulum membrane
L0042802molecular_functionidentical protein binding
L0042803molecular_functionprotein homodimerization activity
L0043005cellular_componentneuron projection
L0043204cellular_componentperikaryon
L0043274molecular_functionphospholipase binding
L0045202cellular_componentsynapse
L0046686biological_processresponse to cadmium ion
L0046777biological_processprotein autophosphorylation
L0048169biological_processregulation of long-term neuronal synaptic plasticity
L0048858biological_processcell projection morphogenesis
L0050885biological_processneuromuscular process controlling balance
L0051233cellular_componentspindle midzone
L0060291biological_processlong-term synaptic potentiation
L0060466biological_processactivation of meiosis involved in egg activation
L0061003biological_processpositive regulation of dendritic spine morphogenesis
L0090128biological_processregulation of synapse maturation
L0090129biological_processpositive regulation of synapse maturation
L0097190biological_processapoptotic signaling pathway
L0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
L0098974biological_processpostsynaptic actin cytoskeleton organization
L0098978cellular_componentglutamatergic synapse
L0106310molecular_functionprotein serine kinase activity
L0110088biological_processhippocampal neuron apoptotic process
L1903076biological_processregulation of protein localization to plasma membrane
L1905375biological_processcellular response to homocysteine
L1990911biological_processresponse to psychosocial stress
L2001222biological_processregulation of neuron migration
L2001235biological_processpositive regulation of apoptotic signaling pathway
N0000082biological_processG1/S transition of mitotic cell cycle
N0003674molecular_functionmolecular_function
N0004674molecular_functionprotein serine/threonine kinase activity
N0004683molecular_functioncalmodulin-dependent protein kinase activity
N0005515molecular_functionprotein binding
N0005516molecular_functioncalmodulin binding
N0005524molecular_functionATP binding
N0005575cellular_componentcellular_component
N0005737cellular_componentcytoplasm
N0005813cellular_componentcentrosome
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
N0006091biological_processgeneration of precursor metabolites and energy
N0006816biological_processcalcium ion transport
N0007399biological_processnervous system development
N0008218biological_processbioluminescence
N0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
N0010976biological_processpositive regulation of neuron projection development
N0014069cellular_componentpostsynaptic density
N0016020cellular_componentmembrane
N0016310biological_processphosphorylation
N0016529cellular_componentsarcoplasmic reticulum
N0019901molecular_functionprotein kinase binding
N0030154biological_processcell differentiation
N0030425cellular_componentdendrite
N0032222biological_processregulation of synaptic transmission, cholinergic
N0033017cellular_componentsarcoplasmic reticulum membrane
N0042802molecular_functionidentical protein binding
N0042803molecular_functionprotein homodimerization activity
N0043005cellular_componentneuron projection
N0043204cellular_componentperikaryon
N0043274molecular_functionphospholipase binding
N0045202cellular_componentsynapse
N0046686biological_processresponse to cadmium ion
N0046777biological_processprotein autophosphorylation
N0048169biological_processregulation of long-term neuronal synaptic plasticity
N0048858biological_processcell projection morphogenesis
N0050885biological_processneuromuscular process controlling balance
N0051233cellular_componentspindle midzone
N0060291biological_processlong-term synaptic potentiation
N0060466biological_processactivation of meiosis involved in egg activation
N0061003biological_processpositive regulation of dendritic spine morphogenesis
N0090128biological_processregulation of synapse maturation
N0090129biological_processpositive regulation of synapse maturation
N0097190biological_processapoptotic signaling pathway
N0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
N0098974biological_processpostsynaptic actin cytoskeleton organization
N0098978cellular_componentglutamatergic synapse
N0106310molecular_functionprotein serine kinase activity
N0110088biological_processhippocampal neuron apoptotic process
N1903076biological_processregulation of protein localization to plasma membrane
N1905375biological_processcellular response to homocysteine
N1990911biological_processresponse to psychosocial stress
N2001222biological_processregulation of neuron migration
N2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGAFSVVRrCvklctghe..........YAAK
ChainResidueDetails
AILE20-LYS43

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNLLL
ChainResidueDetails
AVAL132-LEU144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsMOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132
ChainResidueDetails
ATYR-187
KTYR-187
LTYR-187
NTYR-187
BTYR-187
CTYR-187
DTYR-187
FTYR-187
GTYR-187
HTYR-187
ITYR-187
JTYR-187

site_idSWS_FT_FI2
Number of Residues24
DetailsCROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132
ChainResidueDetails
AGLY-188
FGLY-186
GGLY-188
GGLY-186
HGLY-188
HGLY-186
IGLY-188
IGLY-186
JGLY-188
JGLY-186
KGLY-188
AGLY-186
KGLY-186
LGLY-188
LGLY-186
NGLY-188
NGLY-186
BGLY-188
BGLY-186
CGLY-188
CGLY-186
DGLY-188
DGLY-186
FGLY-188

site_idSWS_FT_FI3
Number of Residues12
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP136
KASP136
LASP136
NASP136
BASP136
CASP136
DASP136
FASP136
GASP136
HASP136
IASP136
JASP136

site_idSWS_FT_FI4
Number of Residues24
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE20
FLYS43
GILE20
GLYS43
HILE20
HLYS43
IILE20
ILYS43
JILE20
JLYS43
KILE20
ALYS43
KLYS43
LILE20
LLYS43
NILE20
NLYS43
BILE20
BLYS43
CILE20
CLYS43
DILE20
DLYS43
FILE20

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P28652
ChainResidueDetails
ATYR17
KTYR17
LTYR17
NTYR17
BTYR17
CTYR17
DTYR17
FTYR17
GTYR17
HTYR17
ITYR17
JTYR17

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17272343
ChainResidueDetails
AALA287
KALA287
LALA287
NALA287
BALA287
CALA287
DALA287
FALA287
GALA287
HALA287
IALA287
JALA287

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250
ChainResidueDetails
AALA306
FALA307
GALA306
GALA307
HALA306
HALA307
IALA306
IALA307
JALA306
JALA307
KALA306
AALA307
KALA307
LALA306
LALA307
NALA306
NALA307
BALA306
BALA307
CALA306
CALA307
DALA306
DALA307
FALA306

site_idSWS_FT_FI8
Number of Residues36
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER367
DSER367
DSER394
DSER397
FSER367
FSER394
FSER397
GSER367
GSER394
GSER397
HSER367
ASER394
HSER394
HSER397
ISER367
ISER394
ISER397
JSER367
JSER394
JSER397
KSER367
KSER394
ASER397
KSER397
LSER367
LSER394
LSER397
NSER367
NSER394
NSER397
BSER367
BSER394
BSER397
CSER367
CSER394
CSER397

site_idSWS_FT_FI9
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28652
ChainResidueDetails
ASER371
KSER371
LSER371
NSER371
BSER371
CSER371
DSER371
FSER371
GSER371
HSER371
ISER371
JSER371

site_idSWS_FT_FI10
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P28652
ChainResidueDetails
ATHR400
KTHR400
LTHR400
NTHR400
BTHR400
CTHR400
DTHR400
FTHR400
GTHR400
HTHR400
ITHR400
JTHR400

site_idSWS_FT_FI11
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR401
KTHR401
LTHR401
NTHR401
BTHR401
CTHR401
DTHR401
FTHR401
GTHR401
HTHR401
ITHR401
JTHR401

223790

PDB entries from 2024-08-14

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