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8T4J

Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006952biological_processdefense response
A0015031biological_processprotein transport
A0015433molecular_functionABC-type peptide antigen transporter activity
A0015833biological_processpeptide transport
A0016020cellular_componentmembrane
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0023029molecular_functionMHC class Ib protein binding
A0030670cellular_componentphagocytic vesicle membrane
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034451cellular_componentcentriolar satellite
A0042288molecular_functionMHC class I protein binding
A0042605molecular_functionpeptide antigen binding
A0042803molecular_functionprotein homodimerization activity
A0042824cellular_componentMHC class I peptide loading complex
A0042825cellular_componentTAP complex
A0043531molecular_functionADP binding
A0046872molecular_functionmetal ion binding
A0046967biological_processcytosol to endoplasmic reticulum transport
A0046978molecular_functionTAP1 binding
A0046979molecular_functionTAP2 binding
A0055085biological_processtransmembrane transport
A1904680molecular_functionpeptide transmembrane transporter activity
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002250biological_processadaptive immune response
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002485biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
B0002489biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0015031biological_processprotein transport
B0015433molecular_functionABC-type peptide antigen transporter activity
B0015440molecular_functionABC-type peptide transporter activity
B0015833biological_processpeptide transport
B0016020cellular_componentmembrane
B0016607cellular_componentnuclear speck
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0023029molecular_functionMHC class Ib protein binding
B0030670cellular_componentphagocytic vesicle membrane
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0042605molecular_functionpeptide antigen binding
B0042824cellular_componentMHC class I peptide loading complex
B0042825cellular_componentTAP complex
B0046872molecular_functionmetal ion binding
B0046967biological_processcytosol to endoplasmic reticulum transport
B0046968biological_processpeptide antigen transport
B0046978molecular_functionTAP1 binding
B0046980molecular_functiontapasin binding
B0055085biological_processtransmembrane transport
B1904680molecular_functionpeptide transmembrane transporter activity
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQAVALARAL
ChainResidueDetails
ALEU643-LEU657
BLEU607-LEU621

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues446
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AGLY17-ASP32
AALA95-ASP126
ALEU189-SER238
AGLU290-GLU358
AALA405-SER688

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ATRP33-PRO53

site_idSWS_FT_FI3
Number of Residues49
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
ALEU54-CYS73
ALEU148-GLY167
ALEU260-VAL268
APHE380-GLU383
BTYR430-LEU686

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AGLY74-ALA94

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ASER127-ALA147

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AGLY168-SER188

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AALA239-HIS259

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ALEU269-THR289

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ASER359-SER379

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AGLU384-GLU404

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P36370, ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AILE478

site_idSWS_FT_FI12
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11532960, ECO:0007744|PDB:1JJ7
ChainResidueDetails
ATHR485

site_idSWS_FT_FI13
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P36370
ChainResidueDetails
AVAL581
ASER641

225158

PDB entries from 2024-09-18

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