8T46
Transporter associated with antigen processing (TAP) in the apo state
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQAVALARAL |
| Chain | Residue | Details |
| A | LEU643-LEU657 | |
| B | LEU607-LEU621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-LEU6 | |
| B | SER78-PRO98 | |
| B | PRO170-HIS187 | |
| B | ILE288-THR293 | |
| B | LEU396-SER408 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | ARG7-LEU27 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 428 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | GLY28-ARG56 | |
| B | SER120-ASP148 | |
| B | CYS209-LEU266 | |
| B | GLN315-ALA374 | |
| B | TYR430-LEU686 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | GLY57-VAL77 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | TRP99-LEU119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | LEU149-ILE169 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | ALA188-GLY208 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | ASN267-SER287 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | LEU294-HIS314 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | LEU375-GLY395 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| B | LEU409-ILE429 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| B | GLY503 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | SITE: Inter-subunit salt bridge with TAPBP => ECO:0000269|PubMed:26611325 |
| Chain | Residue | Details |
| B | ASP16 | |
| A | SER641 |
