8T3R
Cryo-EM Analysis of AE1 Structure in 100 mM NaCl Buffer: Form1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006820 | biological_process | monoatomic anion transport |
A | 0006821 | biological_process | chloride transport |
A | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
A | 0007596 | biological_process | blood coagulation |
A | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
A | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
A | 0015108 | molecular_function | chloride transmembrane transporter activity |
A | 0015297 | molecular_function | antiporter activity |
A | 0015701 | biological_process | bicarbonate transport |
A | 0016020 | cellular_component | membrane |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0017121 | biological_process | plasma membrane phospholipid scrambling |
A | 0030018 | cellular_component | Z disc |
A | 0030492 | molecular_function | hemoglobin binding |
A | 0030506 | molecular_function | ankyrin binding |
A | 0030863 | cellular_component | cortical cytoskeleton |
A | 0035811 | biological_process | negative regulation of urine volume |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043495 | molecular_function | protein-membrane adaptor activity |
A | 0045852 | biological_process | pH elevation |
A | 0048821 | biological_process | erythrocyte development |
A | 0051453 | biological_process | regulation of intracellular pH |
A | 0055085 | biological_process | transmembrane transport |
A | 0070062 | cellular_component | extracellular exosome |
A | 0072562 | cellular_component | blood microparticle |
A | 0072659 | biological_process | protein localization to plasma membrane |
A | 0098660 | biological_process | inorganic ion transmembrane transport |
A | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
A | 0170014 | cellular_component | ankyrin-1 complex |
A | 1902476 | biological_process | chloride transmembrane transport |
A | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
B | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006820 | biological_process | monoatomic anion transport |
B | 0006821 | biological_process | chloride transport |
B | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
B | 0007596 | biological_process | blood coagulation |
B | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
B | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
B | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
B | 0015108 | molecular_function | chloride transmembrane transporter activity |
B | 0015297 | molecular_function | antiporter activity |
B | 0015701 | biological_process | bicarbonate transport |
B | 0016020 | cellular_component | membrane |
B | 0016323 | cellular_component | basolateral plasma membrane |
B | 0017121 | biological_process | plasma membrane phospholipid scrambling |
B | 0030018 | cellular_component | Z disc |
B | 0030492 | molecular_function | hemoglobin binding |
B | 0030506 | molecular_function | ankyrin binding |
B | 0030863 | cellular_component | cortical cytoskeleton |
B | 0035811 | biological_process | negative regulation of urine volume |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043495 | molecular_function | protein-membrane adaptor activity |
B | 0045852 | biological_process | pH elevation |
B | 0048821 | biological_process | erythrocyte development |
B | 0051453 | biological_process | regulation of intracellular pH |
B | 0055085 | biological_process | transmembrane transport |
B | 0070062 | cellular_component | extracellular exosome |
B | 0072562 | cellular_component | blood microparticle |
B | 0072659 | biological_process | protein localization to plasma membrane |
B | 0098660 | biological_process | inorganic ion transmembrane transport |
B | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
B | 0170014 | cellular_component | ankyrin-1 complex |
B | 1902476 | biological_process | chloride transmembrane transport |
B | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1080 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | MET1-PRO403 | |
B | GLN457-LEU459 | |
B | PHE507-ARG518 | |
B | LYS592-ARG602 | |
B | THR685-SER700 | |
B | LEU738-ARG760 | |
B | SER801-GLY838 | |
B | ARG870-VAL911 | |
A | GLN457-LEU459 | |
A | PHE507-ARG518 | |
A | LYS592-ARG602 | |
A | THR685-SER700 | |
A | LEU738-ARG760 | |
A | SER801-GLY838 | |
A | ARG870-VAL911 | |
B | MET1-PRO403 |
site_id | SWS_FT_FI2 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | GLN404-LEU427 | |
B | GLN404-LEU427 |
site_id | SWS_FT_FI3 |
Number of Residues | 164 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | GLY428-MET435 | |
A | SER477-GLU485 | |
A | LYS542-THR570 | |
A | ILE624-MET663 | |
B | GLY428-MET435 | |
B | SER477-GLU485 | |
B | LYS542-THR570 | |
B | ILE624-MET663 |
site_id | SWS_FT_FI4 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | GLY436-ALA456 | |
B | GLY436-ALA456 |
site_id | SWS_FT_FI5 |
Number of Residues | 32 |
Details | TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | LEU460-PHE476 | |
B | LEU460-PHE476 |
site_id | SWS_FT_FI6 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | TYR486-ALA506 | |
B | TYR486-ALA506 |
site_id | SWS_FT_FI7 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | TYR519-ILE541 | |
B | TYR519-ILE541 |
site_id | SWS_FT_FI8 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | ALA571-PHE591 | |
B | ALA571-PHE591 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | ARG603-PHE623 | |
B | ARG603-PHE623 |
site_id | SWS_FT_FI10 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | MET664-ILE684 | |
B | MET664-ILE684 |
site_id | SWS_FT_FI11 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | GLY701-PHE719 | |
B | GLY701-PHE719 |
site_id | SWS_FT_FI12 |
Number of Residues | 34 |
Details | TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | GLY720-ALA737 | |
B | GLY720-ALA737 |
site_id | SWS_FT_FI13 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | ILE761-SER781 | |
B | ILE761-SER781 |
site_id | SWS_FT_FI14 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | ARG782-LEU800 | |
B | ARG782-LEU800 |
site_id | SWS_FT_FI15 |
Number of Residues | 60 |
Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571 |
Chain | Residue | Details |
A | ILE839-LEU869 | |
B | ILE839-LEU869 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | SITE: Important for anion transport |
Chain | Residue | Details |
A | LYS590 | |
B | LYS590 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | SITE: Important for anion-proton cotransport |
Chain | Residue | Details |
A | GLU681 | |
B | GLU681 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |
site_id | SWS_FT_FI19 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697 |
Chain | Residue | Details |
A | TYR8 | |
A | TYR21 | |
B | TYR8 | |
B | TYR21 |
site_id | SWS_FT_FI20 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697 |
Chain | Residue | Details |
A | TYR46 | |
B | TYR46 |
site_id | SWS_FT_FI21 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562 |
Chain | Residue | Details |
A | SER185 | |
B | SER185 |
site_id | SWS_FT_FI22 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919 |
Chain | Residue | Details |
A | SER350 | |
B | SER350 |
site_id | SWS_FT_FI23 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405 |
Chain | Residue | Details |
A | TYR359 | |
A | TYR904 | |
B | TYR359 | |
B | TYR904 |
site_id | SWS_FT_FI24 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574 |
Chain | Residue | Details |
A | CYS843 | |
B | CYS843 |
site_id | SWS_FT_FI25 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865 |
Chain | Residue | Details |
A | ASN642 | |
B | ASN642 |