8T1L

Atomic model of the mammalian mouse Mediator complex with CKM module

Functional Information from GO Data

Chain	GOid	namespace	contents
9	0003712	molecular_function	transcription coregulator activity
9	0006357	biological_process	regulation of transcription by RNA polymerase II
9	0016592	cellular_component	mediator complex
A	0003712	molecular_function	transcription coregulator activity
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016592	cellular_component	mediator complex
B	0003712	molecular_function	transcription coregulator activity
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016592	cellular_component	mediator complex
C	0003712	molecular_function	transcription coregulator activity
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016592	cellular_component	mediator complex
D	0003712	molecular_function	transcription coregulator activity
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016592	cellular_component	mediator complex
E	0003712	molecular_function	transcription coregulator activity
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016592	cellular_component	mediator complex
F	0003712	molecular_function	transcription coregulator activity
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
G	0003712	molecular_function	transcription coregulator activity
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
H	0003712	molecular_function	transcription coregulator activity
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016592	cellular_component	mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016592	cellular_component	mediator complex
J	0003712	molecular_function	transcription coregulator activity
J	0006355	biological_process	regulation of DNA-templated transcription
K	0016592	cellular_component	mediator complex
L	0003712	molecular_function	transcription coregulator activity
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0016592	cellular_component	mediator complex
M	0003712	molecular_function	transcription coregulator activity
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0016592	cellular_component	mediator complex
O	0003712	molecular_function	transcription coregulator activity
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0016592	cellular_component	mediator complex
P	0016592	cellular_component	mediator complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0016592	cellular_component	mediator complex
S	0016592	cellular_component	mediator complex
V	0016592	cellular_component	mediator complex
X	0016592	cellular_component	mediator complex
Z	0003712	molecular_function	transcription coregulator activity
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0016592	cellular_component	mediator complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UHV7

Chain	Residue	Details
9	SER395
9	SER500
9	SER504
9	SER825
9	SER889
9	SER1028
A	SER1405
A	SER1483

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
9	SER530
9	SER537
I	SER1133
I	SER1141
I	SER1149
A	SER1467
A	SER1481
A	SER1484

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	THR805
A	THR1051
A	THR1057
A	THR1442

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332

Chain	Residue	Details
A	SER953

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER955

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by MAPK1 or MAPK3 => ECO:0000250|UniProtKB:Q15648

Chain	Residue	Details
A	THR1032
A	THR1459

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q15648

Chain	Residue	Details
A	LYS1179
A	LYS1523

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q15648

Chain	Residue	Details
A	THR1217

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