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8T1K

DSBU crosslinked nNOS-CaM oxygenase homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001917cellular_componentphotoreceptor inner segment
A0002028biological_processregulation of sodium ion transport
A0003008biological_processsystem process
A0004517molecular_functionnitric-oxide synthase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006527biological_processL-arginine catabolic process
A0006809biological_processnitric oxide biosynthetic process
A0006813biological_processpotassium ion transport
A0006816biological_processcalcium ion transport
A0006941biological_processstriated muscle contraction
A0007154biological_processcell communication
A0007263biological_processnitric oxide mediated signal transduction
A0007565biological_processfemale pregnancy
A0008270molecular_functionzinc ion binding
A0008285biological_processnegative regulation of cell population proliferation
A0009408biological_processresponse to heat
A0009612biological_processresponse to mechanical stimulus
A0009725biological_processresponse to hormone
A0010181molecular_functionFMN binding
A0010288biological_processresponse to lead ion
A0012505cellular_componentendomembrane system
A0014069cellular_componentpostsynaptic density
A0014823biological_processresponse to activity
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016529cellular_componentsarcoplasmic reticulum
A0017080molecular_functionsodium channel regulator activity
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0023052biological_processsignaling
A0030018cellular_componentZ disc
A0030141cellular_componentsecretory granule
A0030315cellular_componentT-tubule
A0030425cellular_componentdendrite
A0031667biological_processresponse to nutrient levels
A0031965cellular_componentnuclear membrane
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0033197biological_processresponse to vitamin E
A0033552biological_processresponse to vitamin B3
A0033555biological_processmulticellular organismal response to stress
A0034760biological_processnegative regulation of iron ion transmembrane transport
A0035094biological_processresponse to nicotine
A0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
A0036293biological_processresponse to decreased oxygen levels
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0042178biological_processxenobiotic catabolic process
A0042311biological_processvasodilation
A0042383cellular_componentsarcolemma
A0042582cellular_componentazurophil granule
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043066biological_processnegative regulation of apoptotic process
A0043197cellular_componentdendritic spine
A0043267biological_processnegative regulation of potassium ion transport
A0043271biological_processnegative regulation of monoatomic ion transport
A0043434biological_processresponse to peptide hormone
A0043524biological_processnegative regulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043627biological_processresponse to estrogen
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0045121cellular_componentmembrane raft
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0045471biological_processresponse to ethanol
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
A0045776biological_processnegative regulation of blood pressure
A0045893biological_processpositive regulation of DNA-templated transcription
A0045906biological_processnegative regulation of vasoconstriction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046209biological_processnitric oxide metabolic process
A0046676biological_processnegative regulation of insulin secretion
A0046870molecular_functioncadmium ion binding
A0046872molecular_functionmetal ion binding
A0048148biological_processbehavioral response to cocaine
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050767biological_processregulation of neurogenesis
A0051117molecular_functionATPase binding
A0051219molecular_functionphosphoprotein binding
A0051481biological_processnegative regulation of cytosolic calcium ion concentration
A0051612biological_processnegative regulation of serotonin uptake
A0051649biological_processestablishment of localization in cell
A0051926biological_processnegative regulation of calcium ion transport
A0060078biological_processregulation of postsynaptic membrane potential
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061875biological_processnegative regulation of hepatic stellate cell contraction
A0065008biological_processregulation of biological quality
A0070402molecular_functionNADPH binding
A0071260biological_processcellular response to mechanical stimulus
A0071363biological_processcellular response to growth factor stimulus
A0071731biological_processresponse to nitric oxide
A0071872biological_processcellular response to epinephrine stimulus
A0071879biological_processpositive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
A0071944cellular_componentcell periphery
A0097110molecular_functionscaffold protein binding
A0098735biological_processpositive regulation of the force of heart contraction
A0098978cellular_componentglutamatergic synapse
A0099091cellular_componentpostsynaptic specialization, intracellular component
A0099092cellular_componentpostsynaptic density, intracellular component
A0099163biological_processsynaptic signaling by nitric oxide
A0106071biological_processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1902307biological_processpositive regulation of sodium ion transmembrane transport
A1903522biological_processregulation of blood circulation
B0001666biological_processresponse to hypoxia
B0001917cellular_componentphotoreceptor inner segment
B0002028biological_processregulation of sodium ion transport
B0003008biological_processsystem process
B0004517molecular_functionnitric-oxide synthase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0006527biological_processL-arginine catabolic process
B0006809biological_processnitric oxide biosynthetic process
B0006813biological_processpotassium ion transport
B0006816biological_processcalcium ion transport
B0006941biological_processstriated muscle contraction
B0007154biological_processcell communication
B0007263biological_processnitric oxide mediated signal transduction
B0007565biological_processfemale pregnancy
B0008270molecular_functionzinc ion binding
B0008285biological_processnegative regulation of cell population proliferation
B0009408biological_processresponse to heat
B0009612biological_processresponse to mechanical stimulus
B0009725biological_processresponse to hormone
B0010181molecular_functionFMN binding
B0010288biological_processresponse to lead ion
B0012505cellular_componentendomembrane system
B0014069cellular_componentpostsynaptic density
B0014823biological_processresponse to activity
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016529cellular_componentsarcoplasmic reticulum
B0017080molecular_functionsodium channel regulator activity
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0023052biological_processsignaling
B0030018cellular_componentZ disc
B0030141cellular_componentsecretory granule
B0030315cellular_componentT-tubule
B0030425cellular_componentdendrite
B0031667biological_processresponse to nutrient levels
B0031965cellular_componentnuclear membrane
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0033197biological_processresponse to vitamin E
B0033552biological_processresponse to vitamin B3
B0033555biological_processmulticellular organismal response to stress
B0034760biological_processnegative regulation of iron ion transmembrane transport
B0035094biological_processresponse to nicotine
B0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
B0036293biological_processresponse to decreased oxygen levels
B0038060biological_processnitric oxide-cGMP-mediated signaling
B0042178biological_processxenobiotic catabolic process
B0042311biological_processvasodilation
B0042383cellular_componentsarcolemma
B0042582cellular_componentazurophil granule
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043066biological_processnegative regulation of apoptotic process
B0043197cellular_componentdendritic spine
B0043267biological_processnegative regulation of potassium ion transport
B0043271biological_processnegative regulation of monoatomic ion transport
B0043434biological_processresponse to peptide hormone
B0043524biological_processnegative regulation of neuron apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0043627biological_processresponse to estrogen
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0045121cellular_componentmembrane raft
B0045184biological_processestablishment of protein localization
B0045202cellular_componentsynapse
B0045471biological_processresponse to ethanol
B0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
B0045776biological_processnegative regulation of blood pressure
B0045893biological_processpositive regulation of DNA-templated transcription
B0045906biological_processnegative regulation of vasoconstriction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046209biological_processnitric oxide metabolic process
B0046676biological_processnegative regulation of insulin secretion
B0046870molecular_functioncadmium ion binding
B0046872molecular_functionmetal ion binding
B0048148biological_processbehavioral response to cocaine
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050767biological_processregulation of neurogenesis
B0051117molecular_functionATPase binding
B0051219molecular_functionphosphoprotein binding
B0051481biological_processnegative regulation of cytosolic calcium ion concentration
B0051612biological_processnegative regulation of serotonin uptake
B0051649biological_processestablishment of localization in cell
B0051926biological_processnegative regulation of calcium ion transport
B0060078biological_processregulation of postsynaptic membrane potential
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061875biological_processnegative regulation of hepatic stellate cell contraction
B0065008biological_processregulation of biological quality
B0070402molecular_functionNADPH binding
B0071260biological_processcellular response to mechanical stimulus
B0071363biological_processcellular response to growth factor stimulus
B0071731biological_processresponse to nitric oxide
B0071872biological_processcellular response to epinephrine stimulus
B0071879biological_processpositive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
B0071944cellular_componentcell periphery
B0097110molecular_functionscaffold protein binding
B0098735biological_processpositive regulation of the force of heart contraction
B0098978cellular_componentglutamatergic synapse
B0099091cellular_componentpostsynaptic specialization, intracellular component
B0099092cellular_componentpostsynaptic density, intracellular component
B0099163biological_processsynaptic signaling by nitric oxide
B0106071biological_processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1902307biological_processpositive regulation of sodium ion transmembrane transport
B1903522biological_processregulation of blood circulation
Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG414-TRP421

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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