8T0K

Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
b	0001917	cellular_component	photoreceptor inner segment
b	0003723	molecular_function	RNA binding
b	0003924	molecular_function	GTPase activity
b	0005515	molecular_function	protein binding
b	0005525	molecular_function	GTP binding
b	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
b	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
b	0005737	cellular_component	cytoplasm
b	0005874	cellular_component	microtubule
b	0005886	cellular_component	plasma membrane
b	0005905	cellular_component	clathrin-coated pit
b	0006897	biological_process	endocytosis
b	0006898	biological_process	receptor-mediated endocytosis
b	0007032	biological_process	endosome organization
b	0008017	molecular_function	microtubule binding
b	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
b	0016787	molecular_function	hydrolase activity
b	0019003	molecular_function	GDP binding
b	0019901	molecular_function	protein kinase binding
b	0030117	cellular_component	membrane coat
b	0030139	cellular_component	endocytic vesicle
b	0031410	cellular_component	cytoplasmic vesicle
b	0031623	biological_process	receptor internalization
b	0042583	cellular_component	chromaffin granule
b	0042802	molecular_function	identical protein binding
b	0042803	molecular_function	protein homodimerization activity
b	0042995	cellular_component	cell projection
b	0045202	cellular_component	synapse
b	0048488	biological_process	synaptic vesicle endocytosis
b	0050804	biological_process	modulation of chemical synaptic transmission
b	0051260	biological_process	protein homooligomerization
b	0051289	biological_process	protein homotetramerization
b	0070062	cellular_component	extracellular exosome
b	0097494	biological_process	regulation of vesicle size
b	0098684	cellular_component	photoreceptor ribbon synapse
b	0098793	cellular_component	presynapse
b	0098835	cellular_component	presynaptic endocytic zone membrane
b	0098978	cellular_component	glutamatergic synapse
b	0099049	biological_process	clathrin coat assembly involved in endocytosis
b	0099050	biological_process	vesicle scission
c	0001917	cellular_component	photoreceptor inner segment
c	0003723	molecular_function	RNA binding
c	0003924	molecular_function	GTPase activity
c	0005515	molecular_function	protein binding
c	0005525	molecular_function	GTP binding
c	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
c	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
c	0005737	cellular_component	cytoplasm
c	0005874	cellular_component	microtubule
c	0005886	cellular_component	plasma membrane
c	0005905	cellular_component	clathrin-coated pit
c	0006897	biological_process	endocytosis
c	0006898	biological_process	receptor-mediated endocytosis
c	0007032	biological_process	endosome organization
c	0008017	molecular_function	microtubule binding
c	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
c	0016787	molecular_function	hydrolase activity
c	0019003	molecular_function	GDP binding
c	0019901	molecular_function	protein kinase binding
c	0030117	cellular_component	membrane coat
c	0030139	cellular_component	endocytic vesicle
c	0031410	cellular_component	cytoplasmic vesicle
c	0031623	biological_process	receptor internalization
c	0042583	cellular_component	chromaffin granule
c	0042802	molecular_function	identical protein binding
c	0042803	molecular_function	protein homodimerization activity
c	0042995	cellular_component	cell projection
c	0045202	cellular_component	synapse
c	0048488	biological_process	synaptic vesicle endocytosis
c	0050804	biological_process	modulation of chemical synaptic transmission
c	0051260	biological_process	protein homooligomerization
c	0051289	biological_process	protein homotetramerization
c	0070062	cellular_component	extracellular exosome
c	0097494	biological_process	regulation of vesicle size
c	0098684	cellular_component	photoreceptor ribbon synapse
c	0098793	cellular_component	presynapse
c	0098835	cellular_component	presynaptic endocytic zone membrane
c	0098978	cellular_component	glutamatergic synapse
c	0099049	biological_process	clathrin coat assembly involved in endocytosis
c	0099050	biological_process	vesicle scission
f	0001917	cellular_component	photoreceptor inner segment
f	0003723	molecular_function	RNA binding
f	0003924	molecular_function	GTPase activity
f	0005515	molecular_function	protein binding
f	0005525	molecular_function	GTP binding
f	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
f	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
f	0005737	cellular_component	cytoplasm
f	0005874	cellular_component	microtubule
f	0005886	cellular_component	plasma membrane
f	0005905	cellular_component	clathrin-coated pit
f	0006897	biological_process	endocytosis
f	0006898	biological_process	receptor-mediated endocytosis
f	0007032	biological_process	endosome organization
f	0008017	molecular_function	microtubule binding
f	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
f	0016787	molecular_function	hydrolase activity
f	0019003	molecular_function	GDP binding
f	0019901	molecular_function	protein kinase binding
f	0030117	cellular_component	membrane coat
f	0030139	cellular_component	endocytic vesicle
f	0031410	cellular_component	cytoplasmic vesicle
f	0031623	biological_process	receptor internalization
f	0042583	cellular_component	chromaffin granule
f	0042802	molecular_function	identical protein binding
f	0042803	molecular_function	protein homodimerization activity
f	0042995	cellular_component	cell projection
f	0045202	cellular_component	synapse
f	0048488	biological_process	synaptic vesicle endocytosis
f	0050804	biological_process	modulation of chemical synaptic transmission
f	0051260	biological_process	protein homooligomerization
f	0051289	biological_process	protein homotetramerization
f	0070062	cellular_component	extracellular exosome
f	0097494	biological_process	regulation of vesicle size
f	0098684	cellular_component	photoreceptor ribbon synapse
f	0098793	cellular_component	presynapse
f	0098835	cellular_component	presynaptic endocytic zone membrane
f	0098978	cellular_component	glutamatergic synapse
f	0099049	biological_process	clathrin coat assembly involved in endocytosis
f	0099050	biological_process	vesicle scission
g	0001917	cellular_component	photoreceptor inner segment
g	0003723	molecular_function	RNA binding
g	0003924	molecular_function	GTPase activity
g	0005515	molecular_function	protein binding
g	0005525	molecular_function	GTP binding
g	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
g	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
g	0005737	cellular_component	cytoplasm
g	0005874	cellular_component	microtubule
g	0005886	cellular_component	plasma membrane
g	0005905	cellular_component	clathrin-coated pit
g	0006897	biological_process	endocytosis
g	0006898	biological_process	receptor-mediated endocytosis
g	0007032	biological_process	endosome organization
g	0008017	molecular_function	microtubule binding
g	0016185	biological_process	synaptic vesicle budding from presynaptic endocytic zone membrane
g	0016787	molecular_function	hydrolase activity
g	0019003	molecular_function	GDP binding
g	0019901	molecular_function	protein kinase binding
g	0030117	cellular_component	membrane coat
g	0030139	cellular_component	endocytic vesicle
g	0031410	cellular_component	cytoplasmic vesicle
g	0031623	biological_process	receptor internalization
g	0042583	cellular_component	chromaffin granule
g	0042802	molecular_function	identical protein binding
g	0042803	molecular_function	protein homodimerization activity
g	0042995	cellular_component	cell projection
g	0045202	cellular_component	synapse
g	0048488	biological_process	synaptic vesicle endocytosis
g	0050804	biological_process	modulation of chemical synaptic transmission
g	0051260	biological_process	protein homooligomerization
g	0051289	biological_process	protein homotetramerization
g	0070062	cellular_component	extracellular exosome
g	0097494	biological_process	regulation of vesicle size
g	0098684	cellular_component	photoreceptor ribbon synapse
g	0098793	cellular_component	presynapse
g	0098835	cellular_component	presynaptic endocytic zone membrane
g	0098978	cellular_component	glutamatergic synapse
g	0099049	biological_process	clathrin coat assembly involved in endocytosis
g	0099050	biological_process	vesicle scission

Functional Information from PROSITE/UniProt

site_id	PS00410
Number of Residues	10
Details	G_DYNAMIN_1 Dynamin-type guanine nucleotide-binding (G) domain signature. LPRGSGIVTR

Chain	Residue	Details
b	LEU57-ARG66

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0007744|PDB:5D3Q

Chain	Residue	Details
b	SER41
c	SER41
f	SER41
g	SER41

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:2X2F, ECO:0007744|PDB:5D3Q

Chain	Residue	Details
b	GLY43
f	SER45
f	LYS206
f	ASP208
g	GLY43
g	SER45
g	LYS206
g	ASP208
b	SER45
b	LYS206
b	ASP208
c	GLY43
c	SER45
c	LYS206
c	ASP208
f	GLY43

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0000269|PubMed:30069048, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:2X2F, ECO:0007744|PDB:5D3Q, ECO:0007744|PDB:6DLU

Chain	Residue	Details
b	ALA44
c	GLN239
f	ALA44
f	SER46
f	ASN236
f	ARG237
f	GLN239
g	ALA44
g	SER46
g	ASN236
g	ARG237
b	SER46
g	GLN239
b	ASN236
b	ARG237
b	GLN239
c	ALA44
c	SER46
c	ASN236
c	ARG237

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:26612256, ECO:0007744|PDB:5D3Q

Chain	Residue	Details
b	ARG59
c	ARG59
f	ARG59
g	ARG59

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:2X2F

Chain	Residue	Details
b	GLY60
c	GLY60
f	GLY60
g	GLY60

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:26612256, ECO:0000269|PubMed:30069048, ECO:0007744|PDB:2X2E, ECO:0007744|PDB:5D3Q, ECO:0007744|PDB:6DLU

Chain	Residue	Details
b	ASP211
c	ASP211
f	ASP211
g	ASP211

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
b	TYR80
b	TYR354
c	TYR80
c	TYR354
f	TYR80
f	TYR354
g	TYR80
g	TYR354

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; alternate => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
b	TYR125
c	TYR125
f	TYR125
g	TYR125

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
b	SER306
b	SER512
c	SER306
c	SER512
f	SER306
f	SER512
g	SER306
g	SER512

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21575

Chain	Residue	Details
b	SER347
c	SER857
f	SER347
f	SER778
f	SER822
f	SER851
f	SER857
g	SER347
g	SER778
g	SER822
g	SER851
b	SER778
g	SER857
b	SER822
b	SER851
b	SER857
c	SER347
c	SER778
c	SER822
c	SER851

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000269|PubMed:29668686

Chain	Residue	Details
b	SER774
c	SER774
f	SER774
g	SER774

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P39053

Chain	Residue	Details
b	ARG796
c	ARG796
f	ARG796
g	ARG796

---