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8SZN

Crystal structure of Neisseria meningitidis ClpP protease in complex with phosphine oxide compound ACP6-12

Functional Information from GO Data
ChainGOidnamespacecontents
A0004176molecular_functionATP-dependent peptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005737cellular_componentcytoplasm
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0008236molecular_functionserine-type peptidase activity
A0009368cellular_componentendopeptidase Clp complex
A0051117molecular_functionATPase binding
B0004176molecular_functionATP-dependent peptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005737cellular_componentcytoplasm
B0006508biological_processproteolysis
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0008236molecular_functionserine-type peptidase activity
B0009368cellular_componentendopeptidase Clp complex
B0051117molecular_functionATPase binding
C0004176molecular_functionATP-dependent peptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005737cellular_componentcytoplasm
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0008236molecular_functionserine-type peptidase activity
C0009368cellular_componentendopeptidase Clp complex
C0051117molecular_functionATPase binding
D0004176molecular_functionATP-dependent peptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005737cellular_componentcytoplasm
D0006508biological_processproteolysis
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0008236molecular_functionserine-type peptidase activity
D0009368cellular_componentendopeptidase Clp complex
D0051117molecular_functionATPase binding
E0004176molecular_functionATP-dependent peptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005737cellular_componentcytoplasm
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0008236molecular_functionserine-type peptidase activity
E0009368cellular_componentendopeptidase Clp complex
E0051117molecular_functionATPase binding
F0004176molecular_functionATP-dependent peptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005737cellular_componentcytoplasm
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0008236molecular_functionserine-type peptidase activity
F0009368cellular_componentendopeptidase Clp complex
F0051117molecular_functionATPase binding
G0004176molecular_functionATP-dependent peptidase activity
G0004252molecular_functionserine-type endopeptidase activity
G0005737cellular_componentcytoplasm
G0006508biological_processproteolysis
G0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
G0008236molecular_functionserine-type peptidase activity
G0009368cellular_componentendopeptidase Clp complex
G0051117molecular_functionATPase binding
H0004176molecular_functionATP-dependent peptidase activity
H0004252molecular_functionserine-type endopeptidase activity
H0005737cellular_componentcytoplasm
H0006508biological_processproteolysis
H0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
H0008236molecular_functionserine-type peptidase activity
H0009368cellular_componentendopeptidase Clp complex
H0051117molecular_functionATPase binding
I0004176molecular_functionATP-dependent peptidase activity
I0004252molecular_functionserine-type endopeptidase activity
I0005737cellular_componentcytoplasm
I0006508biological_processproteolysis
I0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
I0008236molecular_functionserine-type peptidase activity
I0009368cellular_componentendopeptidase Clp complex
I0051117molecular_functionATPase binding
J0004176molecular_functionATP-dependent peptidase activity
J0004252molecular_functionserine-type endopeptidase activity
J0005737cellular_componentcytoplasm
J0006508biological_processproteolysis
J0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
J0008236molecular_functionserine-type peptidase activity
J0009368cellular_componentendopeptidase Clp complex
J0051117molecular_functionATPase binding
K0004176molecular_functionATP-dependent peptidase activity
K0004252molecular_functionserine-type endopeptidase activity
K0005737cellular_componentcytoplasm
K0006508biological_processproteolysis
K0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
K0008236molecular_functionserine-type peptidase activity
K0009368cellular_componentendopeptidase Clp complex
K0051117molecular_functionATPase binding
L0004176molecular_functionATP-dependent peptidase activity
L0004252molecular_functionserine-type endopeptidase activity
L0005737cellular_componentcytoplasm
L0006508biological_processproteolysis
L0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
L0008236molecular_functionserine-type peptidase activity
L0009368cellular_componentendopeptidase Clp complex
L0051117molecular_functionATPase binding
M0004176molecular_functionATP-dependent peptidase activity
M0004252molecular_functionserine-type endopeptidase activity
M0005737cellular_componentcytoplasm
M0006508biological_processproteolysis
M0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
M0008236molecular_functionserine-type peptidase activity
M0009368cellular_componentendopeptidase Clp complex
M0051117molecular_functionATPase binding
N0004176molecular_functionATP-dependent peptidase activity
N0004252molecular_functionserine-type endopeptidase activity
N0005737cellular_componentcytoplasm
N0006508biological_processproteolysis
N0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
N0008236molecular_functionserine-type peptidase activity
N0009368cellular_componentendopeptidase Clp complex
N0051117molecular_functionATPase binding
V0004176molecular_functionATP-dependent peptidase activity
V0004252molecular_functionserine-type endopeptidase activity
V0005737cellular_componentcytoplasm
V0006508biological_processproteolysis
V0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
V0008236molecular_functionserine-type peptidase activity
V0009368cellular_componentendopeptidase Clp complex
V0051117molecular_functionATPase binding
W0004176molecular_functionATP-dependent peptidase activity
W0004252molecular_functionserine-type endopeptidase activity
W0005737cellular_componentcytoplasm
W0006508biological_processproteolysis
W0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
W0008236molecular_functionserine-type peptidase activity
W0009368cellular_componentendopeptidase Clp complex
W0051117molecular_functionATPase binding
X0004176molecular_functionATP-dependent peptidase activity
X0004252molecular_functionserine-type endopeptidase activity
X0005737cellular_componentcytoplasm
X0006508biological_processproteolysis
X0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
X0008236molecular_functionserine-type peptidase activity
X0009368cellular_componentendopeptidase Clp complex
X0051117molecular_functionATPase binding
Y0004176molecular_functionATP-dependent peptidase activity
Y0004252molecular_functionserine-type endopeptidase activity
Y0005737cellular_componentcytoplasm
Y0006508biological_processproteolysis
Y0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Y0008236molecular_functionserine-type peptidase activity
Y0009368cellular_componentendopeptidase Clp complex
Y0051117molecular_functionATPase binding
Z0004176molecular_functionATP-dependent peptidase activity
Z0004252molecular_functionserine-type endopeptidase activity
Z0005737cellular_componentcytoplasm
Z0006508biological_processproteolysis
Z0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
Z0008236molecular_functionserine-type peptidase activity
Z0009368cellular_componentendopeptidase Clp complex
Z0051117molecular_functionATPase binding
a0004176molecular_functionATP-dependent peptidase activity
a0004252molecular_functionserine-type endopeptidase activity
a0005737cellular_componentcytoplasm
a0006508biological_processproteolysis
a0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
a0008236molecular_functionserine-type peptidase activity
a0009368cellular_componentendopeptidase Clp complex
a0051117molecular_functionATPase binding
b0004176molecular_functionATP-dependent peptidase activity
b0004252molecular_functionserine-type endopeptidase activity
b0005737cellular_componentcytoplasm
b0006508biological_processproteolysis
b0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
b0008236molecular_functionserine-type peptidase activity
b0009368cellular_componentendopeptidase Clp complex
b0051117molecular_functionATPase binding
Functional Information from PROSITE/UniProt
site_idPS00381
Number of Residues12
DetailsCLP_PROTEASE_SER Endopeptidase Clp serine active site. TlcLGqAASMGA
ChainResidueDetails
VTHR94-ALA105

site_idPS00382
Number of Residues14
DetailsCLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnsrIMIHQP
ChainResidueDetails
VARG116-PRO129

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
VSER102
CSER102
DSER102
ESER102
FSER102
GSER102
HSER102
ISER102
JSER102
KSER102
LSER102
WSER102
MSER102
NSER102
XSER102
YSER102
ZSER102
aSER102
bSER102
ASER102
BSER102

site_idSWS_FT_FI2
Number of Residues21
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00444
ChainResidueDetails
VHIS127
CHIS127
DHIS127
EHIS127
FHIS127
GHIS127
HHIS127
IHIS127
JHIS127
KHIS127
LHIS127
WHIS127
MHIS127
NHIS127
XHIS127
YHIS127
ZHIS127
aHIS127
bHIS127
AHIS127
BHIS127

227344

PDB entries from 2024-11-13

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