8SZL

Human liver-type glutaminase (Apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0006543	biological_process	glutamine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0042981	biological_process	regulation of apoptotic process
A	0072593	biological_process	reactive oxygen species metabolic process
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0006543	biological_process	glutamine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0042981	biological_process	regulation of apoptotic process
B	0072593	biological_process	reactive oxygen species metabolic process
C	0004359	molecular_function	glutaminase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0006543	biological_process	glutamine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0042981	biological_process	regulation of apoptotic process
C	0072593	biological_process	reactive oxygen species metabolic process
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006520	biological_process	amino acid metabolic process
D	0006537	biological_process	glutamate biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0006543	biological_process	glutamine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0042981	biological_process	regulation of apoptotic process
D	0072593	biological_process	reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O94925

Chain	Residue	Details
A	SER219
B	GLU314
B	ASN321
B	TYR347
B	TYR399
B	VAL417
C	SER219
C	ASN268
C	GLU314
C	ASN321
C	TYR347
A	ASN268
C	TYR399
C	VAL417
D	SER219
D	ASN268
D	GLU314
D	ASN321
D	TYR347
D	TYR399
D	VAL417
A	GLU314
A	ASN321
A	TYR347
A	TYR399
A	VAL417
B	SER219
B	ASN268

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q571F8

Chain	Residue	Details
A	LYS253
B	LYS253
C	LYS253
D	LYS253

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site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q571F8

Chain	Residue	Details
A	LYS279
D	LYS279
D	LYS284
D	LYS329
A	LYS284
A	LYS329
B	LYS279
B	LYS284
B	LYS329
C	LYS279
C	LYS284
C	LYS329

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