Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SXA

Inward-facing wide conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARVNLARAV

Chain	Residue	Details
A	LEU535-VAL549
A	PHE1177-ILE1191

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	21
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	167
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	31
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	284
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	35
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38216659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SWN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)