Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SV1

Caspase-1 complex with interleukin-18

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004197	molecular_function	cysteine-type endopeptidase activity
a	0006508	biological_process	proteolysis
a	0008234	molecular_function	cysteine-type peptidase activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
b	0004197	molecular_function	cysteine-type endopeptidase activity
b	0006508	biological_process	proteolysis
b	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
c	0001525	biological_process	angiogenesis
c	0002826	biological_process	negative regulation of T-helper 1 type immune response
c	0005125	molecular_function	cytokine activity
c	0005515	molecular_function	protein binding
c	0005576	cellular_component	extracellular region
c	0005615	cellular_component	extracellular space
c	0005829	cellular_component	cytosol
c	0006954	biological_process	inflammatory response
c	0006955	biological_process	immune response
c	0007166	biological_process	cell surface receptor signaling pathway
c	0007267	biological_process	cell-cell signaling
c	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
c	0019221	biological_process	cytokine-mediated signaling pathway
c	0030155	biological_process	regulation of cell adhesion
c	0030431	biological_process	sleep
c	0032722	biological_process	positive regulation of chemokine production
c	0032725	biological_process	positive regulation of granulocyte macrophage colony-stimulating factor production
c	0032729	biological_process	positive regulation of type II interferon production
c	0032736	biological_process	positive regulation of interleukin-13 production
c	0032740	biological_process	positive regulation of interleukin-17 production
c	0032819	biological_process	positive regulation of natural killer cell proliferation
c	0034105	biological_process	positive regulation of tissue remodeling
c	0035655	biological_process	interleukin-18-mediated signaling pathway
c	0042088	biological_process	T-helper 1 type immune response
c	0042092	biological_process	type 2 immune response
c	0042104	biological_process	positive regulation of activated T cell proliferation
c	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
c	0042632	biological_process	cholesterol homeostasis
c	0045063	biological_process	T-helper 1 cell differentiation
c	0045515	molecular_function	interleukin-18 receptor binding
c	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0048018	molecular_function	receptor ligand activity
c	0048661	biological_process	positive regulation of smooth muscle cell proliferation
c	0050729	biological_process	positive regulation of inflammatory response
c	0050830	biological_process	defense response to Gram-positive bacterium
c	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
c	0051142	biological_process	positive regulation of NK T cell proliferation
c	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
c	0061436	biological_process	establishment of skin barrier
c	0070328	biological_process	triglyceride homeostasis
c	0071222	biological_process	cellular response to lipopolysaccharide
c	0120162	biological_process	positive regulation of cold-induced thermogenesis
c	0150078	biological_process	positive regulation of neuroinflammatory response
c	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
c	2000556	biological_process	positive regulation of T-helper 1 cell cytokine production
C	0001525	biological_process	angiogenesis
C	0002826	biological_process	negative regulation of T-helper 1 type immune response
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007267	biological_process	cell-cell signaling
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030155	biological_process	regulation of cell adhesion
C	0030431	biological_process	sleep
C	0032722	biological_process	positive regulation of chemokine production
C	0032725	biological_process	positive regulation of granulocyte macrophage colony-stimulating factor production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032736	biological_process	positive regulation of interleukin-13 production
C	0032740	biological_process	positive regulation of interleukin-17 production
C	0032819	biological_process	positive regulation of natural killer cell proliferation
C	0034105	biological_process	positive regulation of tissue remodeling
C	0035655	biological_process	interleukin-18-mediated signaling pathway
C	0042088	biological_process	T-helper 1 type immune response
C	0042092	biological_process	type 2 immune response
C	0042104	biological_process	positive regulation of activated T cell proliferation
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0042632	biological_process	cholesterol homeostasis
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045515	molecular_function	interleukin-18 receptor binding
C	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048018	molecular_function	receptor ligand activity
C	0048661	biological_process	positive regulation of smooth muscle cell proliferation
C	0050729	biological_process	positive regulation of inflammatory response
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051142	biological_process	positive regulation of NK T cell proliferation
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0061436	biological_process	establishment of skin barrier
C	0070328	biological_process	triglyceride homeostasis
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0150078	biological_process	positive regulation of neuroinflammatory response
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	2000556	biological_process	positive regulation of T-helper 1 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG

Chain	Residue	Details
A	HIS224-GLY238

site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKVIIIQACRG

Chain	Residue	Details
A	LYS276-GLY287

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32051255","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Cleavage; by CASP1, CASP4 and CASP5","evidences":[{"source":"PubMed","id":"25261253","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 718

Chain	Residue	Details
B	GLU390	electrostatic stabiliser
A	GLY238	electrostatic stabiliser
A	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor
A	ARG286	electrostatic stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 718

Chain	Residue	Details
C	PRO93	proton acceptor, proton donor
C	ARG94	electrostatic stabiliser
C	SER141	nucleofuge, nucleophile, proton acceptor, proton donor
C	VAL142	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)