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8SUE

Human asparagine synthetase (apo-ASNS)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004066molecular_functionasparagine synthase (glutamine-hydrolyzing) activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005829cellular_componentcytosol
A0006529biological_processasparagine biosynthetic process
A0006541biological_processglutamine metabolic process
A0016874molecular_functionligase activity
A0042149biological_processcellular response to glucose starvation
A0043066biological_processnegative regulation of apoptotic process
A0045931biological_processpositive regulation of mitotic cell cycle
A0070981biological_processL-asparagine biosynthetic process
B0004066molecular_functionasparagine synthase (glutamine-hydrolyzing) activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005829cellular_componentcytosol
B0006529biological_processasparagine biosynthetic process
B0006541biological_processglutamine metabolic process
B0016874molecular_functionligase activity
B0042149biological_processcellular response to glucose starvation
B0043066biological_processnegative regulation of apoptotic process
B0045931biological_processpositive regulation of mitotic cell cycle
B0070981biological_processL-asparagine biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For GATase activity => ECO:0000269|PubMed:2564390, ECO:0000269|PubMed:2573597
ChainResidueDetails
ACYS1
BCYS1

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG48
BLEU255
BILE287
BSER362
AASN74
AASP96
ALEU255
AILE287
ASER362
BARG48
BASN74
BASP96

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Important for beta-aspartyl-AMP intermediate formation => ECO:0000250
ChainResidueDetails
AGLU364
BGLU364

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS384
BLYS384

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR544
BTHR544

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER556
BSER556

222624

PDB entries from 2024-07-17

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