8SUE
Human asparagine synthetase (apo-ASNS)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004066 | molecular_function | asparagine synthase (glutamine-hydrolyzing) activity |
| A | 0004071 | molecular_function | aspartate-ammonia ligase activity |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0042149 | biological_process | cellular response to glucose starvation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045931 | biological_process | positive regulation of mitotic cell cycle |
| A | 0070981 | biological_process | L-asparagine biosynthetic process |
| B | 0004066 | molecular_function | asparagine synthase (glutamine-hydrolyzing) activity |
| B | 0004071 | molecular_function | aspartate-ammonia ligase activity |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0042149 | biological_process | cellular response to glucose starvation |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0045931 | biological_process | positive regulation of mitotic cell cycle |
| B | 0070981 | biological_process | L-asparagine biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For glutamine amidotransferase activity","evidences":[{"source":"PubMed","id":"2573597","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31552298","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P22106","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for beta-aspartyl-AMP intermediate formation","evidences":[{"source":"UniProtKB","id":"P22106","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
