8SOA

Phosphoinositide phosphate 3 kinase gamma bound with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001525	biological_process	angiogenesis
A	0002376	biological_process	immune system process
A	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
A	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
A	0006629	biological_process	lipid metabolic process
A	0006897	biological_process	endocytosis
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0016477	biological_process	cell migration
A	0016740	molecular_function	transferase activity
A	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A	0048015	biological_process	phosphatidylinositol-mediated signaling
A	0106310	molecular_function	protein serine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005942	cellular_component	phosphatidylinositol 3-kinase complex
B	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ

Chain	Residue	Details
A	PHE832-GLN846

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN

Chain	Residue	Details
A	SER931-ASN951

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	92
Details	Domain: {"description":"PI3K-RBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00879","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090628","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"UniProtKB","id":"Q9JHG7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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