8SNI
Hydroxynitrile Lyase from Hevea brasiliensis with Forty Mutations
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VILVGHSLGG |
| Chain | Residue | Details |
| A | VAL74-GLY83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"14998991","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18524775","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10548044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14998991","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18524775","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C6Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3YAS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14998991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SC9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Increases basicity of active site His","evidences":[{"source":"PubMed","id":"18524775","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 217 |
| Chain | Residue | Details |
| A | GLY11 | electrostatic stabiliser, hydrogen bond donor |
| A | SER80 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| A | LEU81 | electrostatic stabiliser |
| A | ASP209 | electrostatic stabiliser, increase acidity, increase basicity |
| A | HIS237 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | MET238 | activator, electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 217 |
| Chain | Residue | Details |
| B | GLY11 | electrostatic stabiliser, hydrogen bond donor |
| B | SER80 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| B | LEU81 | electrostatic stabiliser |
| B | ASP209 | electrostatic stabiliser, increase acidity, increase basicity |
| B | HIS237 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | MET238 | activator, electrostatic stabiliser, hydrogen bond donor, steric role |






