8SNI
Hydroxynitrile Lyase from Hevea brasiliensis with Forty Mutations
Functional Information from PROSITE/UniProt
site_id | PS00120 |
Number of Residues | 10 |
Details | LIPASE_SER Lipases, serine active site. VILVGHSLGG |
Chain | Residue | Details |
A | VAL74-GLY83 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:14998991, ECO:0000305|PubMed:18524775 |
Chain | Residue | Details |
A | SER80 | |
A | HIS237 | |
B | SER80 | |
B | HIS237 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10548044, ECO:0000269|PubMed:14998991, ECO:0000269|PubMed:18524775, ECO:0007744|PDB:1SCK, ECO:0007744|PDB:3C6Y, ECO:0007744|PDB:3YAS |
Chain | Residue | Details |
A | GLY11 | |
A | SER80 | |
B | GLY11 | |
B | SER80 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14998991, ECO:0007744|PDB:1SC9 |
Chain | Residue | Details |
A | MET238 | |
B | MET238 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Increases basicity of active site His => ECO:0000305|PubMed:18524775 |
Chain | Residue | Details |
A | ASP209 | |
B | ASP209 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 217 |
Chain | Residue | Details |
A | GLY11 | electrostatic stabiliser, hydrogen bond donor |
A | SER80 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
A | LEU81 | electrostatic stabiliser |
A | ASP209 | electrostatic stabiliser, increase acidity, increase basicity |
A | HIS237 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | MET238 | activator, electrostatic stabiliser, hydrogen bond donor, steric role |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 217 |
Chain | Residue | Details |
B | GLY11 | electrostatic stabiliser, hydrogen bond donor |
B | SER80 | electrostatic stabiliser, proton acceptor, proton donor, proton relay |
B | LEU81 | electrostatic stabiliser |
B | ASP209 | electrostatic stabiliser, increase acidity, increase basicity |
B | HIS237 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | MET238 | activator, electrostatic stabiliser, hydrogen bond donor, steric role |