8SL4

Dimeric form of human adenylyl cyclase 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003091	biological_process	renal water homeostasis
A	0004016	molecular_function	adenylate cyclase activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006171	biological_process	cAMP biosynthetic process
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0008179	molecular_function	adenylate cyclase binding
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0035556	biological_process	intracellular signal transduction
A	0046872	molecular_function	metal ion binding
A	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
A	0071377	biological_process	cellular response to glucagon stimulus
A	0097110	molecular_function	scaffold protein binding
A	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress
A	1904322	biological_process	cellular response to forskolin
B	0000166	molecular_function	nucleotide binding
B	0003091	biological_process	renal water homeostasis
B	0004016	molecular_function	adenylate cyclase activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006171	biological_process	cAMP biosynthetic process
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0008179	molecular_function	adenylate cyclase binding
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0016020	cellular_component	membrane
B	0016829	molecular_function	lyase activity
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0035556	biological_process	intracellular signal transduction
B	0046872	molecular_function	metal ion binding
B	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
B	0071377	biological_process	cellular response to glucagon stimulus
B	0097110	molecular_function	scaffold protein binding
B	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress
B	1904322	biological_process	cellular response to forskolin

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVL.GlrkwqFdVWSNDVTlanhmE

Chain	Residue	Details
A	GLY573-GLU596
A	GLY1187-ASP1210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	440
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	104
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	254
Details	Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	278
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26769","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q03343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q03343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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