8SL4
Dimeric form of human adenylyl cyclase 5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003008 | biological_process | system process |
| A | 0003091 | biological_process | renal water homeostasis |
| A | 0004016 | molecular_function | adenylate cyclase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0006171 | biological_process | cAMP biosynthetic process |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0008179 | molecular_function | adenylate cyclase binding |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0061178 | biological_process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0071377 | biological_process | cellular response to glucagon stimulus |
| A | 0097110 | molecular_function | scaffold protein binding |
| A | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| A | 1904322 | biological_process | cellular response to forskolin |
| B | 0003008 | biological_process | system process |
| B | 0003091 | biological_process | renal water homeostasis |
| B | 0004016 | molecular_function | adenylate cyclase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005929 | cellular_component | cilium |
| B | 0006171 | biological_process | cAMP biosynthetic process |
| B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0008179 | molecular_function | adenylate cyclase binding |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0061178 | biological_process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0071377 | biological_process | cellular response to glucagon stimulus |
| B | 0097110 | molecular_function | scaffold protein binding |
| B | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| B | 1904322 | biological_process | cellular response to forskolin |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVL.GlrkwqFdVWSNDVTlanhmE |
| Chain | Residue | Details |
| A | GLY573-GLU596 | |
| A | GLY1187-ASP1210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 254 |
| Details | Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 278 |
| Details | Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P30803","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P26769","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q03343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q03343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
