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8SKS

human liver mitochondrial Superoxide dismutase [Mn]

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001666biological_processresponse to hypoxia
A0001836biological_processrelease of cytochrome c from mitochondria
A0001889biological_processliver development
A0003032biological_processdetection of oxygen
A0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
A0003677molecular_functionDNA binding
A0004784molecular_functionsuperoxide dismutase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006357biological_processregulation of transcription by RNA polymerase II
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007507biological_processheart development
A0007626biological_processlocomotory behavior
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
A0008637biological_processapoptotic mitochondrial changes
A0009410biological_processresponse to xenobiotic stimulus
A0009791biological_processpost-embryonic development
A0010042biological_processresponse to manganese ion
A0010043biological_processresponse to zinc ion
A0010269biological_processresponse to selenium ion
A0010332biological_processresponse to gamma radiation
A0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
A0014823biological_processresponse to activity
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0022904biological_processrespiratory electron transport chain
A0030097biological_processhemopoiesis
A0030145molecular_functionmanganese ion binding
A0030335biological_processpositive regulation of cell migration
A0031667biological_processresponse to nutrient levels
A0032364biological_processintracellular oxygen homeostasis
A0032496biological_processresponse to lipopolysaccharide
A0033591biological_processresponse to L-ascorbic acid
A0034021biological_processresponse to silicon dioxide
A0034599biological_processcellular response to oxidative stress
A0035900biological_processresponse to isolation stress
A0035902biological_processresponse to immobilization stress
A0042311biological_processvasodilation
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042645cellular_componentmitochondrial nucleoid
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045599biological_processnegative regulation of fat cell differentiation
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0048147biological_processnegative regulation of fibroblast proliferation
A0048666biological_processneuron development
A0048678biological_processresponse to axon injury
A0048773biological_processerythrophore differentiation
A0050665biological_processhydrogen peroxide biosynthetic process
A0051289biological_processprotein homotetramerization
A0051602biological_processresponse to electrical stimulus
A0051881biological_processregulation of mitochondrial membrane potential
A0055093biological_processresponse to hyperoxia
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070062cellular_componentextracellular exosome
A0071000biological_processresponse to magnetism
A0071361biological_processcellular response to ethanol
A0072593biological_processreactive oxygen species metabolic process
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902631biological_processnegative regulation of membrane hyperpolarization
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
A1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
B0000302biological_processresponse to reactive oxygen species
B0000303biological_processresponse to superoxide
B0001666biological_processresponse to hypoxia
B0001836biological_processrelease of cytochrome c from mitochondria
B0001889biological_processliver development
B0003032biological_processdetection of oxygen
B0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
B0003677molecular_functionDNA binding
B0004784molecular_functionsuperoxide dismutase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006357biological_processregulation of transcription by RNA polymerase II
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006979biological_processresponse to oxidative stress
B0007005biological_processmitochondrion organization
B0007507biological_processheart development
B0007626biological_processlocomotory behavior
B0008217biological_processregulation of blood pressure
B0008285biological_processnegative regulation of cell population proliferation
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
B0008637biological_processapoptotic mitochondrial changes
B0009410biological_processresponse to xenobiotic stimulus
B0009791biological_processpost-embryonic development
B0010042biological_processresponse to manganese ion
B0010043biological_processresponse to zinc ion
B0010269biological_processresponse to selenium ion
B0010332biological_processresponse to gamma radiation
B0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
B0014823biological_processresponse to activity
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0019825molecular_functionoxygen binding
B0019899molecular_functionenzyme binding
B0022904biological_processrespiratory electron transport chain
B0030097biological_processhemopoiesis
B0030145molecular_functionmanganese ion binding
B0030335biological_processpositive regulation of cell migration
B0031667biological_processresponse to nutrient levels
B0032364biological_processintracellular oxygen homeostasis
B0032496biological_processresponse to lipopolysaccharide
B0033591biological_processresponse to L-ascorbic acid
B0034021biological_processresponse to silicon dioxide
B0034599biological_processcellular response to oxidative stress
B0035900biological_processresponse to isolation stress
B0035902biological_processresponse to immobilization stress
B0042311biological_processvasodilation
B0042542biological_processresponse to hydrogen peroxide
B0042554biological_processsuperoxide anion generation
B0042645cellular_componentmitochondrial nucleoid
B0042743biological_processhydrogen peroxide metabolic process
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045599biological_processnegative regulation of fat cell differentiation
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0048147biological_processnegative regulation of fibroblast proliferation
B0048666biological_processneuron development
B0048678biological_processresponse to axon injury
B0048773biological_processerythrophore differentiation
B0050665biological_processhydrogen peroxide biosynthetic process
B0051289biological_processprotein homotetramerization
B0051602biological_processresponse to electrical stimulus
B0051881biological_processregulation of mitochondrial membrane potential
B0055093biological_processresponse to hyperoxia
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071000biological_processresponse to magnetism
B0071361biological_processcellular response to ethanol
B0072593biological_processreactive oxygen species metabolic process
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902631biological_processnegative regulation of membrane hyperpolarization
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
B1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
C0000302biological_processresponse to reactive oxygen species
C0000303biological_processresponse to superoxide
C0001666biological_processresponse to hypoxia
C0001836biological_processrelease of cytochrome c from mitochondria
C0001889biological_processliver development
C0003032biological_processdetection of oxygen
C0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
C0003677molecular_functionDNA binding
C0004784molecular_functionsuperoxide dismutase activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006357biological_processregulation of transcription by RNA polymerase II
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006979biological_processresponse to oxidative stress
C0007005biological_processmitochondrion organization
C0007507biological_processheart development
C0007626biological_processlocomotory behavior
C0008217biological_processregulation of blood pressure
C0008285biological_processnegative regulation of cell population proliferation
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
C0008637biological_processapoptotic mitochondrial changes
C0009410biological_processresponse to xenobiotic stimulus
C0009791biological_processpost-embryonic development
C0010042biological_processresponse to manganese ion
C0010043biological_processresponse to zinc ion
C0010269biological_processresponse to selenium ion
C0010332biological_processresponse to gamma radiation
C0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
C0014823biological_processresponse to activity
C0016491molecular_functionoxidoreductase activity
C0019430biological_processremoval of superoxide radicals
C0019825molecular_functionoxygen binding
C0019899molecular_functionenzyme binding
C0022904biological_processrespiratory electron transport chain
C0030097biological_processhemopoiesis
C0030145molecular_functionmanganese ion binding
C0030335biological_processpositive regulation of cell migration
C0031667biological_processresponse to nutrient levels
C0032364biological_processintracellular oxygen homeostasis
C0032496biological_processresponse to lipopolysaccharide
C0033591biological_processresponse to L-ascorbic acid
C0034021biological_processresponse to silicon dioxide
C0034599biological_processcellular response to oxidative stress
C0035900biological_processresponse to isolation stress
C0035902biological_processresponse to immobilization stress
C0042311biological_processvasodilation
C0042542biological_processresponse to hydrogen peroxide
C0042554biological_processsuperoxide anion generation
C0042645cellular_componentmitochondrial nucleoid
C0042743biological_processhydrogen peroxide metabolic process
C0042802molecular_functionidentical protein binding
C0043066biological_processnegative regulation of apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0045599biological_processnegative regulation of fat cell differentiation
C0046686biological_processresponse to cadmium ion
C0046872molecular_functionmetal ion binding
C0048147biological_processnegative regulation of fibroblast proliferation
C0048666biological_processneuron development
C0048678biological_processresponse to axon injury
C0048773biological_processerythrophore differentiation
C0050665biological_processhydrogen peroxide biosynthetic process
C0051289biological_processprotein homotetramerization
C0051602biological_processresponse to electrical stimulus
C0051881biological_processregulation of mitochondrial membrane potential
C0055093biological_processresponse to hyperoxia
C0060586biological_processmulticellular organismal-level iron ion homeostasis
C0070062cellular_componentextracellular exosome
C0071000biological_processresponse to magnetism
C0071361biological_processcellular response to ethanol
C0072593biological_processreactive oxygen species metabolic process
C1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1902631biological_processnegative regulation of membrane hyperpolarization
C1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
C1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
C1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
D0000302biological_processresponse to reactive oxygen species
D0000303biological_processresponse to superoxide
D0001666biological_processresponse to hypoxia
D0001836biological_processrelease of cytochrome c from mitochondria
D0001889biological_processliver development
D0003032biological_processdetection of oxygen
D0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
D0003677molecular_functionDNA binding
D0004784molecular_functionsuperoxide dismutase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006357biological_processregulation of transcription by RNA polymerase II
D0006749biological_processglutathione metabolic process
D0006801biological_processsuperoxide metabolic process
D0006979biological_processresponse to oxidative stress
D0007005biological_processmitochondrion organization
D0007507biological_processheart development
D0007626biological_processlocomotory behavior
D0008217biological_processregulation of blood pressure
D0008285biological_processnegative regulation of cell population proliferation
D0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
D0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
D0008637biological_processapoptotic mitochondrial changes
D0009410biological_processresponse to xenobiotic stimulus
D0009791biological_processpost-embryonic development
D0010042biological_processresponse to manganese ion
D0010043biological_processresponse to zinc ion
D0010269biological_processresponse to selenium ion
D0010332biological_processresponse to gamma radiation
D0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
D0014823biological_processresponse to activity
D0016491molecular_functionoxidoreductase activity
D0019430biological_processremoval of superoxide radicals
D0019825molecular_functionoxygen binding
D0019899molecular_functionenzyme binding
D0022904biological_processrespiratory electron transport chain
D0030097biological_processhemopoiesis
D0030145molecular_functionmanganese ion binding
D0030335biological_processpositive regulation of cell migration
D0031667biological_processresponse to nutrient levels
D0032364biological_processintracellular oxygen homeostasis
D0032496biological_processresponse to lipopolysaccharide
D0033591biological_processresponse to L-ascorbic acid
D0034021biological_processresponse to silicon dioxide
D0034599biological_processcellular response to oxidative stress
D0035900biological_processresponse to isolation stress
D0035902biological_processresponse to immobilization stress
D0042311biological_processvasodilation
D0042542biological_processresponse to hydrogen peroxide
D0042554biological_processsuperoxide anion generation
D0042645cellular_componentmitochondrial nucleoid
D0042743biological_processhydrogen peroxide metabolic process
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045599biological_processnegative regulation of fat cell differentiation
D0046686biological_processresponse to cadmium ion
D0046872molecular_functionmetal ion binding
D0048147biological_processnegative regulation of fibroblast proliferation
D0048666biological_processneuron development
D0048678biological_processresponse to axon injury
D0048773biological_processerythrophore differentiation
D0050665biological_processhydrogen peroxide biosynthetic process
D0051289biological_processprotein homotetramerization
D0051602biological_processresponse to electrical stimulus
D0051881biological_processregulation of mitochondrial membrane potential
D0055093biological_processresponse to hyperoxia
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070062cellular_componentextracellular exosome
D0071000biological_processresponse to magnetism
D0071361biological_processcellular response to ethanol
D0072593biological_processreactive oxygen species metabolic process
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1902631biological_processnegative regulation of membrane hyperpolarization
D1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
D1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
D1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
Functional Information from PROSITE/UniProt
site_idPS00088
Number of Residues8
DetailsSOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY
ChainResidueDetails
AASP183-TYR190

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
ChainResidueDetails
AHIS50
AHIS98
AASP183
AHIS187
BHIS50
BHIS98
BASP183
BHIS187
CHIS50
CHIS98
CASP183
CHIS187
DHIS50
DHIS98
DASP183
DHIS187

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855
ChainResidueDetails
ATYR58
BTYR58
CTYR58
DTYR58

site_idSWS_FT_FI3
Number of Residues16
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
ChainResidueDetails
ALYS68
ALYS75
ALYS122
ALYS130
BLYS68
BLYS75
BLYS122
BLYS130
CLYS68
CLYS75
CLYS122
CLYS130
DLYS68
DLYS75
DLYS122
DLYS130

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09671
ChainResidueDetails
ALYS114
ALYS202
BLYS114
BLYS202
CLYS114
CLYS202
DLYS114
DLYS202

219869

PDB entries from 2024-05-15

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