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8SKK

Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17

Functional Information from GO Data
ChainGOidnamespacecontents
A0019957molecular_functionC-C chemokine binding
A1900137biological_processnegative regulation of chemokine activity
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0030335biological_processpositive regulation of cell migration
B0048020molecular_functionCCR chemokine receptor binding
B0060326biological_processcell chemotaxis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLeyfkga..IplrkLktWyqtsed..Csrd.AIVFvtvqgrai.CS
ChainResidueDetails
BCYS10-SER51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN5
AASN10
AASN30
AASN33
AASN47
AASN61
AASN75
AASN91

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PDB entries from 2024-11-06

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