8SJX

Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (2SM:1Chol)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002088	biological_process	lens development in camera-type eye
A	0005212	molecular_function	structural constituent of eye lens
A	0005516	molecular_function	calmodulin binding
A	0005886	cellular_component	plasma membrane
A	0006833	biological_process	water transport
A	0007601	biological_process	visual perception
A	0015250	molecular_function	water channel activity
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0034109	biological_process	homotypic cell-cell adhesion
A	0036438	biological_process	maintenance of lens transparency
A	0055085	biological_process	transmembrane transport
A	0070161	cellular_component	anchoring junction
A	0098631	molecular_function	cell adhesion mediator activity
A	1990349	biological_process	gap junction-mediated intercellular transport

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGLGSLLYdFllfprlksvserl.....SILK

Chain	Residue	Details
A	ILE210-LYS238

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site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HVNPAVTFA

Chain	Residue	Details
A	HIS66-ALA74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	75
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16319884

Chain	Residue	Details
A	MET1-ALA12
A	GLY60-SER63
A	VAL77-ARG85
A	THR148-LEU157
A	TYR219-LEU263

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	ILE13-ALA30

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:16319884

Chain	Residue	Details
A	SER31-HIS40
A	VAL107-SER126
A	MET176-TYR177
A	LEU194-ASN200

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	VAL41-VAL59

---

site_id	SWS_FT_FI5
Number of Residues	27
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	GLY64-LEU76
A	TYR178-ILE193

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	ALA86-SER106

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	VAL127-ALA147

---

site_id	SWS_FT_FI8
Number of Residues	17
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	GLY158-GLY175

---

site_id	SWS_FT_FI9
Number of Residues	17
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O

Chain	Residue	Details
A	HIS201-LEU218

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	SITE: Important for water channel gating => ECO:0000250|UniProtKB:P06624

Chain	Residue	Details
A	TYR149

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	SITE: Cleavage; promotes interactions between tetramers from adjoining membranes => ECO:0000269|PubMed:15351655

Chain	Residue	Details
A	LEU234
A	SER243

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	SITE: Interaction with BFSP1 => ECO:0000250|UniProtKB:P06624

Chain	Residue	Details
A	ASN246

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	SITE: interaction with BFSP1 => ECO:0000250|UniProtKB:P06624

Chain	Residue	Details
A	GLU250

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06624

Chain	Residue	Details
A	SER235
A	SER243
A	SER245

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