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8SJC

Crystal structure of Zn2+ bound calprotectin

Functional Information from GO Data
ChainGOidnamespacecontents
A0002523biological_processleukocyte migration involved in inflammatory response
A0002544biological_processchronic inflammatory response
A0002790biological_processpeptide secretion
A0002793biological_processpositive regulation of peptide secretion
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0008017molecular_functionmicrotubule binding
A0008270molecular_functionzinc ion binding
A0010043biological_processresponse to zinc ion
A0014002biological_processastrocyte development
A0018119biological_processpeptidyl-cysteine S-nitrosylation
A0030307biological_processpositive regulation of cell growth
A0030593biological_processneutrophil chemotaxis
A0032119biological_processsequestering of zinc ion
A0032496biological_processresponse to lipopolysaccharide
A0034121biological_processregulation of toll-like receptor signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035425biological_processautocrine signaling
A0035662molecular_functionToll-like receptor 4 binding
A0042742biological_processdefense response to bacterium
A0043542biological_processendothelial cell migration
A0045087biological_processinnate immune response
A0045111cellular_componentintermediate filament cytoskeleton
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050544molecular_functionarachidonate binding
A0050729biological_processpositive regulation of inflammatory response
A0050786molecular_functionRAGE receptor binding
A0050832biological_processdefense response to fungus
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051493biological_processregulation of cytoskeleton organization
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070488biological_processneutrophil aggregation
A1990660cellular_componentcalprotectin complex
A1990661cellular_componentS100A8 complex
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0002523biological_processleukocyte migration involved in inflammatory response
B0002544biological_processchronic inflammatory response
B0002790biological_processpeptide secretion
B0002793biological_processpositive regulation of peptide secretion
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0008017molecular_functionmicrotubule binding
B0008270molecular_functionzinc ion binding
B0010043biological_processresponse to zinc ion
B0014002biological_processastrocyte development
B0018119biological_processpeptidyl-cysteine S-nitrosylation
B0030307biological_processpositive regulation of cell growth
B0030593biological_processneutrophil chemotaxis
B0032119biological_processsequestering of zinc ion
B0032496biological_processresponse to lipopolysaccharide
B0034121biological_processregulation of toll-like receptor signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035425biological_processautocrine signaling
B0035662molecular_functionToll-like receptor 4 binding
B0042742biological_processdefense response to bacterium
B0043542biological_processendothelial cell migration
B0045087biological_processinnate immune response
B0045111cellular_componentintermediate filament cytoskeleton
B0045471biological_processresponse to ethanol
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050544molecular_functionarachidonate binding
B0050729biological_processpositive regulation of inflammatory response
B0050786molecular_functionRAGE receptor binding
B0050832biological_processdefense response to fungus
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051493biological_processregulation of cytoskeleton organization
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070488biological_processneutrophil aggregation
B1990660cellular_componentcalprotectin complex
B1990661cellular_componentS100A8 complex
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
C0002523biological_processleukocyte migration involved in inflammatory response
C0002544biological_processchronic inflammatory response
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0007267biological_processcell-cell signaling
C0008017molecular_functionmicrotubule binding
C0008270molecular_functionzinc ion binding
C0010976biological_processpositive regulation of neuron projection development
C0014002biological_processastrocyte development
C0016209molecular_functionantioxidant activity
C0030307biological_processpositive regulation of cell growth
C0030593biological_processneutrophil chemotaxis
C0032119biological_processsequestering of zinc ion
C0034121biological_processregulation of toll-like receptor signaling pathway
C0034774cellular_componentsecretory granule lumen
C0035425biological_processautocrine signaling
C0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
C0035662molecular_functionToll-like receptor 4 binding
C0035821biological_processmodulation of process of another organism
C0042742biological_processdefense response to bacterium
C0043542biological_processendothelial cell migration
C0045087biological_processinnate immune response
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050544molecular_functionarachidonate binding
C0050729biological_processpositive regulation of inflammatory response
C0050786molecular_functionRAGE receptor binding
C0050832biological_processdefense response to fungus
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051493biological_processregulation of cytoskeleton organization
C0060264biological_processregulation of respiratory burst involved in inflammatory response
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0070488biological_processneutrophil aggregation
C0098869biological_processcellular oxidant detoxification
C1990660cellular_componentcalprotectin complex
C1990662cellular_componentS100A9 complex
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
D0002523biological_processleukocyte migration involved in inflammatory response
D0002544biological_processchronic inflammatory response
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006914biological_processautophagy
D0006915biological_processapoptotic process
D0006935biological_processchemotaxis
D0006954biological_processinflammatory response
D0007267biological_processcell-cell signaling
D0008017molecular_functionmicrotubule binding
D0008270molecular_functionzinc ion binding
D0010976biological_processpositive regulation of neuron projection development
D0014002biological_processastrocyte development
D0016209molecular_functionantioxidant activity
D0030307biological_processpositive regulation of cell growth
D0030593biological_processneutrophil chemotaxis
D0032119biological_processsequestering of zinc ion
D0034121biological_processregulation of toll-like receptor signaling pathway
D0034774cellular_componentsecretory granule lumen
D0035425biological_processautocrine signaling
D0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
D0035662molecular_functionToll-like receptor 4 binding
D0035821biological_processmodulation of process of another organism
D0042742biological_processdefense response to bacterium
D0043542biological_processendothelial cell migration
D0045087biological_processinnate immune response
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050544molecular_functionarachidonate binding
D0050729biological_processpositive regulation of inflammatory response
D0050786molecular_functionRAGE receptor binding
D0050832biological_processdefense response to fungus
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051493biological_processregulation of cytoskeleton organization
D0060264biological_processregulation of respiratory burst involved in inflammatory response
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0070488biological_processneutrophil aggregation
D0098869biological_processcellular oxidant detoxification
D1990660cellular_componentcalprotectin complex
D1990662cellular_componentS100A9 complex
D2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINTDGAVNfqEF
ChainResidueDetails
AASP59-PHE71
CASP63-PHE75

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. WFkeLDintDgavNFqEFliLV
ChainResidueDetails
ATRP54-VAL75
CILE58-MET79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305|PubMed:17553524
ChainResidueDetails
CHIS16
BHIS87
CASP26
CHIS87
CHIS91
DHIS16
DASP26
DHIS87
DHIS91
BHIS83

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4
ChainResidueDetails
CSER19
DGLU32
CLEU22
CHIS24
CTHR27
CGLU32
DSER19
DLEU22
DHIS24
DTHR27

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4
ChainResidueDetails
CASP63
DGLU74
CASN65
CASP67
CGLN69
CGLU74
DASP63
DASN65
DASP67
DGLN69

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Pros-methylhistidine => ECO:0000250|UniProtKB:P50116
ChainResidueDetails
CHIS101
DHIS101

231029

PDB entries from 2025-02-05

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