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8SIM

KCNQ1 with voltage sensor in the intermediate conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0002027biological_processregulation of heart rate
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030017cellular_componentsarcomere
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031954biological_processpositive regulation of protein autophosphorylation
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035307biological_processpositive regulation of protein dephosphorylation
B0035458biological_processcellular response to interferon-beta
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0072542molecular_functionprotein phosphatase activator activity
B0097225cellular_componentsperm midpiece
B0098901biological_processregulation of cardiac muscle cell action potential
B0140056biological_processorganelle localization by membrane tethering
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0016020cellular_componentmembrane
C0055085biological_processtransmembrane transport
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processpositive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D0140056biological_processorganelle localization by membrane tethering
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
E0005216molecular_functionmonoatomic ion channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0008076cellular_componentvoltage-gated potassium channel complex
E0016020cellular_componentmembrane
E0055085biological_processtransmembrane transport
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0008076cellular_componentvoltage-gated potassium channel complex
G0016020cellular_componentmembrane
G0055085biological_processtransmembrane transport
H0000086biological_processG2/M transition of mitotic cell cycle
H0000922cellular_componentspindle pole
H0002027biological_processregulation of heart rate
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
H0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016240biological_processautophagosome membrane docking
H0019855molecular_functioncalcium channel inhibitor activity
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0031432molecular_functiontitin binding
H0031514cellular_componentmotile cilium
H0031954biological_processpositive regulation of protein autophosphorylation
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032516biological_processpositive regulation of phosphoprotein phosphatase activity
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0035307biological_processpositive regulation of protein dephosphorylation
H0035458biological_processcellular response to interferon-beta
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044325molecular_functiontransmembrane transporter binding
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050848biological_processregulation of calcium-mediated signaling
H0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
H0071346biological_processcellular response to type II interferon
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0072542molecular_functionprotein phosphatase activator activity
H0097225cellular_componentsperm midpiece
H0098901biological_processregulation of cardiac muscle cell action potential
H0140056biological_processorganelle localization by membrane tethering
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
H1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
BASP21-LEU33
BASP57-PHE69
BASP94-LEU106
BASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
ECYS122-LEU142
BGLU68
DASP21
DASP23
DASP25
DTHR27
DGLU32
DASP57
DASP59
DASN61
DTHR63
ACYS122-LEU142
DGLU68
FASP21
FASP23
FASP25
FTHR27
FGLU32
FASP57
FASP59
FASN61
FTHR63
GCYS122-LEU142
FGLU68
HASP21
HASP23
HASP25
HTHR27
HGLU32
HASP57
HASP59
HASN61
HTHR63
CCYS122-LEU142
HGLU68
BGLU32
BASP57
BASP59
BASN61
BTHR63

site_idSWS_FT_FI2
Number of Residues132
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ESER143-GLN147
GLYS218-SER225
GALA283-TYR299
GGLN321-THR327
CSER143-GLN147
CLYS218-SER225
CALA283-TYR299
CGLN321-THR327
DASP132
DASP134
DGLN136
ELYS218-SER225
DGLU141
FASP94
FASP96
FASN98
FTYR100
FGLU105
FASP130
FASP132
FASP134
FGLN136
EALA283-TYR299
FGLU141
HASP94
HASP96
HASN98
HTYR100
HGLU105
HASP130
HASP132
HASP134
HGLN136
EGLN321-THR327
HGLU141
ASER143-GLN147
ALYS218-SER225
AALA283-TYR299
AGLN321-THR327
GSER143-GLN147

site_idSWS_FT_FI3
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
ETYR148-GLY168
ATYR148-GLY168
GTYR148-GLY168
CTYR148-GLY168

site_idSWS_FT_FI4
Number of Residues156
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ETHR169-LYS196
EARG249-GLU261
ATHR169-LYS196
AARG249-GLU261
GTHR169-LYS196
GARG249-GLU261
CTHR169-LYS196
CARG249-GLU261

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
EPRO197-SER217
APRO197-SER217
GPRO197-SER217
CPRO197-SER217

site_idSWS_FT_FI6
Number of Residues88
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
EALA226-TRP248
AALA226-TRP248
GALA226-TRP248
CALA226-TRP248

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
ELEU262-LEU282
ALEU262-LEU282
GLEU262-LEU282
CLEU262-LEU282

site_idSWS_FT_FI8
Number of Residues80
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
EALA300-PRO320
AALA300-PRO320
GALA300-PRO320
CALA300-PRO320

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
EILE328-GLY348
AILE328-GLY348
GILE328-GLY348
CILE328-GLY348

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97414
ChainResidueDetails
ESER407
ESER409
ASER407
ASER409
GSER407
GSER409
CSER407
CSER409

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN289
AASN289
GASN289
CASN289

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BTYR139
DTYR139
FTYR139
HTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
BLYS22
DLYS22
FLYS22
HLYS22

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PDB entries from 2024-07-17

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